Possible oral transmission of acute Chagas' disease in Brazil Possível transmissão oral de doença de Chagas aguda, no Brasil
In October, 1986, 7 to 22 days after a meeting at a farm in Paraíba state, 26 individuals presented with a febrile illness associated with bilateral eyelid and lower limb edema, mild hepatosplenomegaly, lymphadenopathy and, occasionally a skin rash. A 11-year-old boy exhibited atrial premature compl...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
1991
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ftdoajarticles:oai:doaj.org/article:ceb3026d43ef4e6e85d1b52df3688761 2024-09-09T19:28:28+00:00 Possible oral transmission of acute Chagas' disease in Brazil Possível transmissão oral de doença de Chagas aguda, no Brasil M.A. Shikanai-Yasuda C. Brisola Marcondes L. A. Guedes G.S. Siqueira A.A. Barone J.C.P. Dias V. Amato Neto J.E. Tolezano B.A. Peres E.R. Arruda Jr. M.H. Lopes M. Shiroma E. Chapadeiro 1991-10-01T00:00:00Z https://doi.org/10.1590/S0036-46651991000500003 https://doaj.org/article/ceb3026d43ef4e6e85d1b52df3688761 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651991000500003 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651991000500003 0036-4665 1678-9946 https://doaj.org/article/ceb3026d43ef4e6e85d1b52df3688761 Revista do Instituto de Medicina Tropical de São Paulo, Vol 33, Iss 5, Pp 351-357 (1991) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1991 ftdoajarticles https://doi.org/10.1590/S0036-46651991000500003 2024-08-05T17:49:30Z In October, 1986, 7 to 22 days after a meeting at a farm in Paraíba state, 26 individuals presented with a febrile illness associated with bilateral eyelid and lower limb edema, mild hepatosplenomegaly, lymphadenopathy and, occasionally a skin rash. A 11-year-old boy exhibited atrial premature complexes and a 74-year-old patient developed acute heart failure. In two patients hospitalized in São Paulo city, acute Chagas' disease was diagnosed by the demonstration of circulating Trypanosoma cruzi. At autopsy in a fatal case, acute Chagas' cardiomyopathy was demonstrated. Xenodiagnosis were positive in 9 out of 14 tested patients. A specific IgG immune response was found in all patients and specific IgM antibodies were identified in 20 out of 22 tested patients. A epidemiological survey showed the existence of Triatoma brasiliensis in the outbuildings of this farm, but none in the house where most of the guests stayed. A high rate of infection with Trypanosoma cruzi was found in opossums. These observations together with those related to the food consumed by the patients, lead the authors to suggest that the human infections resulted from oral contamination probably originating from naturally infected marsupials in the area or crushed infected bugs. Em outubro de 1986, 7 a 22 dias após uma reunião em uma fazenda no estado da Paraíba, 26 pessoas apresentaram doença febril, associada a edema bipalpebral bilateral, e de membros inferiores, hepatoesplenomegalia leve, linfadenopatia e, mais raramente, a um exantema. Um menino de 11 anos apresentou arritmia atrial ao eletroeardiograma e um paciente de 74 anos desenvolveu insuficiência cardíaca aguda. Em 2 pacientes hospitalizados em São Paulo, foi estabelecido o diagnóstico de Doença de Chagas aguda por observação de T. cruzi em creme leucocitário. Em autópsia de um caso fatal foi demonstrada cardiomiopatia chagásica aguda. O xenodiagnóstico foi positivo em 9 de 14 pacientes testados. Anticorpos específicos de classe IgG foram encontrados em todos os pacientes e da ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Aguda ENVELOPE(-26.750,-26.750,-76.150,-76.150) Arctic Revista do Instituto de Medicina Tropical de São Paulo 33 5 351 357 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 M.A. Shikanai-Yasuda C. Brisola Marcondes L. A. Guedes G.S. Siqueira A.A. Barone J.C.P. Dias V. Amato Neto J.E. Tolezano B.A. Peres E.R. Arruda Jr. M.H. Lopes M. Shiroma E. Chapadeiro Possible oral transmission of acute Chagas' disease in Brazil Possível transmissão oral de doença de Chagas aguda, no Brasil |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
In October, 1986, 7 to 22 days after a meeting at a farm in Paraíba state, 26 individuals presented with a febrile illness associated with bilateral eyelid and lower limb edema, mild hepatosplenomegaly, lymphadenopathy and, occasionally a skin rash. A 11-year-old boy exhibited atrial premature complexes and a 74-year-old patient developed acute heart failure. In two patients hospitalized in São Paulo city, acute Chagas' disease was diagnosed by the demonstration of circulating Trypanosoma cruzi. At autopsy in a fatal case, acute Chagas' cardiomyopathy was demonstrated. Xenodiagnosis were positive in 9 out of 14 tested patients. A specific IgG immune response was found in all patients and specific IgM antibodies were identified in 20 out of 22 tested patients. A epidemiological survey showed the existence of Triatoma brasiliensis in the outbuildings of this farm, but none in the house where most of the guests stayed. A high rate of infection with Trypanosoma cruzi was found in opossums. These observations together with those related to the food consumed by the patients, lead the authors to suggest that the human infections resulted from oral contamination probably originating from naturally infected marsupials in the area or crushed infected bugs. Em outubro de 1986, 7 a 22 dias após uma reunião em uma fazenda no estado da Paraíba, 26 pessoas apresentaram doença febril, associada a edema bipalpebral bilateral, e de membros inferiores, hepatoesplenomegalia leve, linfadenopatia e, mais raramente, a um exantema. Um menino de 11 anos apresentou arritmia atrial ao eletroeardiograma e um paciente de 74 anos desenvolveu insuficiência cardíaca aguda. Em 2 pacientes hospitalizados em São Paulo, foi estabelecido o diagnóstico de Doença de Chagas aguda por observação de T. cruzi em creme leucocitário. Em autópsia de um caso fatal foi demonstrada cardiomiopatia chagásica aguda. O xenodiagnóstico foi positivo em 9 de 14 pacientes testados. Anticorpos específicos de classe IgG foram encontrados em todos os pacientes e da ... |
format |
Article in Journal/Newspaper |
author |
M.A. Shikanai-Yasuda C. Brisola Marcondes L. A. Guedes G.S. Siqueira A.A. Barone J.C.P. Dias V. Amato Neto J.E. Tolezano B.A. Peres E.R. Arruda Jr. M.H. Lopes M. Shiroma E. Chapadeiro |
author_facet |
M.A. Shikanai-Yasuda C. Brisola Marcondes L. A. Guedes G.S. Siqueira A.A. Barone J.C.P. Dias V. Amato Neto J.E. Tolezano B.A. Peres E.R. Arruda Jr. M.H. Lopes M. Shiroma E. Chapadeiro |
author_sort |
M.A. Shikanai-Yasuda |
title |
Possible oral transmission of acute Chagas' disease in Brazil Possível transmissão oral de doença de Chagas aguda, no Brasil |
title_short |
Possible oral transmission of acute Chagas' disease in Brazil Possível transmissão oral de doença de Chagas aguda, no Brasil |
title_full |
Possible oral transmission of acute Chagas' disease in Brazil Possível transmissão oral de doença de Chagas aguda, no Brasil |
title_fullStr |
Possible oral transmission of acute Chagas' disease in Brazil Possível transmissão oral de doença de Chagas aguda, no Brasil |
title_full_unstemmed |
Possible oral transmission of acute Chagas' disease in Brazil Possível transmissão oral de doença de Chagas aguda, no Brasil |
title_sort |
possible oral transmission of acute chagas' disease in brazil possível transmissão oral de doença de chagas aguda, no brasil |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1991 |
url |
https://doi.org/10.1590/S0036-46651991000500003 https://doaj.org/article/ceb3026d43ef4e6e85d1b52df3688761 |
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ENVELOPE(-26.750,-26.750,-76.150,-76.150) |
geographic |
Aguda Arctic |
geographic_facet |
Aguda Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 33, Iss 5, Pp 351-357 (1991) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651991000500003 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651991000500003 0036-4665 1678-9946 https://doaj.org/article/ceb3026d43ef4e6e85d1b52df3688761 |
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https://doi.org/10.1590/S0036-46651991000500003 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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33 |
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