Use of oral cholera vaccines in an outbreak in Vietnam: a case control study.
BACKGROUND: Killed oral cholera vaccines (OCVs) are available but not used routinely for cholera control except in Vietnam, which produces its own vaccine. In 2007-2008, unprecedented cholera outbreaks occurred in the capital, Hanoi, prompting immunization in two districts. In an outbreak investigat...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0001006 https://doaj.org/article/cea54587506c4f178fb68de91a1b137d |
id |
ftdoajarticles:oai:doaj.org/article:cea54587506c4f178fb68de91a1b137d |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:cea54587506c4f178fb68de91a1b137d 2023-05-15T15:13:23+02:00 Use of oral cholera vaccines in an outbreak in Vietnam: a case control study. Dang Duc Anh Anna Lena Lopez Vu Dinh Thiem Shannon L Grahek Tran Nhu Duong Jin Kyung Park Hye Jung Kwon Michael Favorov Nguyen Tran Hien John D Clemens 2011-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001006 https://doaj.org/article/cea54587506c4f178fb68de91a1b137d EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3026769?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0001006 1935-2727 1935-2735 https://doaj.org/article/cea54587506c4f178fb68de91a1b137d PLoS Neglected Tropical Diseases, Vol 5, Iss 1, p e1006 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001006 2022-12-31T04:43:57Z BACKGROUND: Killed oral cholera vaccines (OCVs) are available but not used routinely for cholera control except in Vietnam, which produces its own vaccine. In 2007-2008, unprecedented cholera outbreaks occurred in the capital, Hanoi, prompting immunization in two districts. In an outbreak investigation, we assessed the effectiveness of killed OCV use after a cholera outbreak began. METHODOLOGY/PRINCIPAL FINDINGS: From 16 to 28 January 2008, vaccination campaigns with the Vietnamese killed OCV were held in two districts of Hanoi. No cholera cases were detected from 5 February to 4 March 2008, after which cases were again identified. Beginning 8 April 2008, residents of four districts of Hanoi admitted to one of five hospitals for acute diarrhea with onset after 5 March 2008 were recruited for a matched, hospital-based, case-control outbreak investigation. Cases were matched by hospital, admission date, district, gender, and age to controls admitted for non-diarrheal conditions. Subjects from the two vaccinated districts were evaluated to determine vaccine effectiveness. 54 case-control pairs from the vaccinated districts were included in the analysis. There were 8 (15%) and 16 (30%) vaccine recipients among cases and controls, respectively. The vaccine was 76% protective against cholera in this setting (95% CI 5% to 94%, P = 0.042) after adjusting for intake of dog meat or raw vegetables and not drinking boiled or bottled water most of the time. CONCLUSIONS/SIGNIFICANCE: This is the first study to explore the effectiveness of the reactive use of killed OCVs during a cholera outbreak. Our findings suggest that killed OCVs may have a role in controlling cholera outbreaks. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 1 e1006 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Dang Duc Anh Anna Lena Lopez Vu Dinh Thiem Shannon L Grahek Tran Nhu Duong Jin Kyung Park Hye Jung Kwon Michael Favorov Nguyen Tran Hien John D Clemens Use of oral cholera vaccines in an outbreak in Vietnam: a case control study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Killed oral cholera vaccines (OCVs) are available but not used routinely for cholera control except in Vietnam, which produces its own vaccine. In 2007-2008, unprecedented cholera outbreaks occurred in the capital, Hanoi, prompting immunization in two districts. In an outbreak investigation, we assessed the effectiveness of killed OCV use after a cholera outbreak began. METHODOLOGY/PRINCIPAL FINDINGS: From 16 to 28 January 2008, vaccination campaigns with the Vietnamese killed OCV were held in two districts of Hanoi. No cholera cases were detected from 5 February to 4 March 2008, after which cases were again identified. Beginning 8 April 2008, residents of four districts of Hanoi admitted to one of five hospitals for acute diarrhea with onset after 5 March 2008 were recruited for a matched, hospital-based, case-control outbreak investigation. Cases were matched by hospital, admission date, district, gender, and age to controls admitted for non-diarrheal conditions. Subjects from the two vaccinated districts were evaluated to determine vaccine effectiveness. 54 case-control pairs from the vaccinated districts were included in the analysis. There were 8 (15%) and 16 (30%) vaccine recipients among cases and controls, respectively. The vaccine was 76% protective against cholera in this setting (95% CI 5% to 94%, P = 0.042) after adjusting for intake of dog meat or raw vegetables and not drinking boiled or bottled water most of the time. CONCLUSIONS/SIGNIFICANCE: This is the first study to explore the effectiveness of the reactive use of killed OCVs during a cholera outbreak. Our findings suggest that killed OCVs may have a role in controlling cholera outbreaks. |
format |
Article in Journal/Newspaper |
author |
Dang Duc Anh Anna Lena Lopez Vu Dinh Thiem Shannon L Grahek Tran Nhu Duong Jin Kyung Park Hye Jung Kwon Michael Favorov Nguyen Tran Hien John D Clemens |
author_facet |
Dang Duc Anh Anna Lena Lopez Vu Dinh Thiem Shannon L Grahek Tran Nhu Duong Jin Kyung Park Hye Jung Kwon Michael Favorov Nguyen Tran Hien John D Clemens |
author_sort |
Dang Duc Anh |
title |
Use of oral cholera vaccines in an outbreak in Vietnam: a case control study. |
title_short |
Use of oral cholera vaccines in an outbreak in Vietnam: a case control study. |
title_full |
Use of oral cholera vaccines in an outbreak in Vietnam: a case control study. |
title_fullStr |
Use of oral cholera vaccines in an outbreak in Vietnam: a case control study. |
title_full_unstemmed |
Use of oral cholera vaccines in an outbreak in Vietnam: a case control study. |
title_sort |
use of oral cholera vaccines in an outbreak in vietnam: a case control study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001006 https://doaj.org/article/cea54587506c4f178fb68de91a1b137d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 1, p e1006 (2011) |
op_relation |
http://europepmc.org/articles/PMC3026769?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0001006 1935-2727 1935-2735 https://doaj.org/article/cea54587506c4f178fb68de91a1b137d |
op_doi |
https://doi.org/10.1371/journal.pntd.0001006 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
5 |
container_issue |
1 |
container_start_page |
e1006 |
_version_ |
1766343938543714304 |