Polineuropatia desmielinizante inflamatória crônica pós-tratamento com interferon peguilado alfa 2b em um paciente co-infectado HIV/HCV: relato de caso Chronic inflammatory demyelinating polyneuropathy after treatment with pegylated interferon alpha 2b in a patient with HIV/HCV coinfection: case report

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Bil Randerson Bassetti, Eduardo Sturzeneker Trés, Jovana Gobbi Marchesi Ciríaco, Lauro Ferreira Silva Pinto Neto
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2010
• Subjects: Polineuropatia desmielinizante inflamatória crônica; Coinfecção HIV/HCV; Interferon peguilado alfa; Polineuropatia; Chronic inflammatory demyelinating polyneuropathy; HIV/HCV coinfection; Pegylated interferon alpha; Polyneuropathy; Arctic medicine. Tropical medicine; RC955-962; Arctic; Droga
• Online Access: https://doi.org/10.1590/S0037-86822010000100019; https://doaj.org/article/cea4e42b1fc7488282bf568a994101e7

A polineuropatia desmielinizante inflamatória cônica possui forte associação com a infecção pelo HIV e HCV. Uma rara associação entre PDIC e o tratamento da hepatite C com interferon peguilado alfa foi descrita recentemente. Nós descrevemos o primeiro caso de polineuropatia desmielinizante inflamatória crônica em um paciente branco, sexo masculino infectado por HIV e HCV associado a interferon peguilado alfa 2b. O paciente recuperou-se completamente após o uso de imunoglobulina hiperimune endovenosa. Infectologistas e hapatologistas devem estar atentos à esta rara e grave associação, que exige imediata descontinuação da droga e tratamento precoce. Chronic inflammatory demyelinating polyneuropathy has a strong association with HIV and HCV infection. A rare association between chronic inflammatory demyelinating polyneuropathy and hepatitis C treatment with pegylated interferon alpha was described recently. We described the first case of chronic inflammatory demyelinating polyneuropathy associated with pegylated interferon alpha 2b in a white man infected with HIV and HCV. The patient recovered completely with the use of intravenous hyperimmune immunoglobulin. Infectologists and hepatologists should be alert regarding this rare and serious association, which requires immediately drug discontinuation and early treatment.