Dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the candesartan and ramipril therapy in patients with heart failure with preserved ejection fraction after myocardial infarction on the background of arter
Abstract. Chronic heart failure (CHF) is actual medical problem around the world and in Ukraine. Almost 50% of these patients have heart failure with preserved ejection fraction. CHF is the result of many complications and cardiovascular disease, such as coronary heart disease, including myocardial...
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ftdoajarticles:oai:doaj.org/article:cea30edf50f14098ae1a544d25be9723 2023-05-15T16:52:55+02:00 Dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the candesartan and ramipril therapy in patients with heart failure with preserved ejection fraction after myocardial infarction on the background of arter Ya. V. Zemlyaniy 2014-04-01T00:00:00Z https://doi.org/10.14739/2310-1210.2014.2.25232 https://doaj.org/article/cea30edf50f14098ae1a544d25be9723 EN RU UK eng rus ukr Zaporozhye State Medical University http://zmj.zsmu.edu.ua/article/view/25232/22652 https://doaj.org/toc/2306-4145 https://doaj.org/toc/2310-1210 doi:10.14739/2310-1210.2014.2.25232 2306-4145 2310-1210 https://doaj.org/article/cea30edf50f14098ae1a544d25be9723 Zaporožskij Medicinskij Žurnal, Iss 2, Pp 13-17 (2014) heart failure with preserved ejection fraction candesartan ramipril myocardial infarction hypertension Medicine R article 2014 ftdoajarticles https://doi.org/10.14739/2310-1210.2014.2.25232 2022-12-31T04:33:12Z Abstract. Chronic heart failure (CHF) is actual medical problem around the world and in Ukraine. Almost 50% of these patients have heart failure with preserved ejection fraction. CHF is the result of many complications and cardiovascular disease, such as coronary heart disease, including myocardial infarction and hypertension. Despite the prevalence of heart failure with preserved ejection fraction a common strategy for the treatment of this disease has not yet been developed. This is due to the limited number of controlled studies in these patients. One of the most effective drugs in the treatment of heart failure with preserved ejection fraction after myocardial infarction are candesartan and ramipril. Determining the dynamics of GDF 15 and NTproBNP along with those of echocardiography is promising for evaluating the effectiveness of treatment of patients with heart failure with preserved ejection fraction after myocardial infarction in the background of arterial hypertension. The aim of research. To determine the dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the ramipril and candesartan therapy in patients with heart failure and preserved ejection fraction after myocardial infarction on the background of arterial hypertension. Materials and methods. 38 patients with heart failure with preserved left ventricular ejection fraction (EF>45%) after myocardial infarction with comorbidity arterial hypertension were included into the study. Dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the ramipril and candesartan therapy for 12 weeks (mean age 64,3 ± 1,3 years) were investigated. Prescription myocardial infarction ranged from 2 months to 3 years. Patients were divided into 2 groups. The first group in addition to the basic treatment received candesartan (KASARK "Arterium", Ukraine) at a mean dose 18,5 ± 2,1 mg daily. Patients of the second group received ramipril (RAMIMED, «Medochemie Ltd.», Iceland/Cyprus) ... Article in Journal/Newspaper Iceland Directory of Open Access Journals: DOAJ Articles Zaporozhye Medical Journal 0 2 |
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English Russian Ukrainian |
topic |
heart failure with preserved ejection fraction candesartan ramipril myocardial infarction hypertension Medicine R |
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heart failure with preserved ejection fraction candesartan ramipril myocardial infarction hypertension Medicine R Ya. V. Zemlyaniy Dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the candesartan and ramipril therapy in patients with heart failure with preserved ejection fraction after myocardial infarction on the background of arter |
topic_facet |
heart failure with preserved ejection fraction candesartan ramipril myocardial infarction hypertension Medicine R |
description |
Abstract. Chronic heart failure (CHF) is actual medical problem around the world and in Ukraine. Almost 50% of these patients have heart failure with preserved ejection fraction. CHF is the result of many complications and cardiovascular disease, such as coronary heart disease, including myocardial infarction and hypertension. Despite the prevalence of heart failure with preserved ejection fraction a common strategy for the treatment of this disease has not yet been developed. This is due to the limited number of controlled studies in these patients. One of the most effective drugs in the treatment of heart failure with preserved ejection fraction after myocardial infarction are candesartan and ramipril. Determining the dynamics of GDF 15 and NTproBNP along with those of echocardiography is promising for evaluating the effectiveness of treatment of patients with heart failure with preserved ejection fraction after myocardial infarction in the background of arterial hypertension. The aim of research. To determine the dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the ramipril and candesartan therapy in patients with heart failure and preserved ejection fraction after myocardial infarction on the background of arterial hypertension. Materials and methods. 38 patients with heart failure with preserved left ventricular ejection fraction (EF>45%) after myocardial infarction with comorbidity arterial hypertension were included into the study. Dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the ramipril and candesartan therapy for 12 weeks (mean age 64,3 ± 1,3 years) were investigated. Prescription myocardial infarction ranged from 2 months to 3 years. Patients were divided into 2 groups. The first group in addition to the basic treatment received candesartan (KASARK "Arterium", Ukraine) at a mean dose 18,5 ± 2,1 mg daily. Patients of the second group received ramipril (RAMIMED, «Medochemie Ltd.», Iceland/Cyprus) ... |
format |
Article in Journal/Newspaper |
author |
Ya. V. Zemlyaniy |
author_facet |
Ya. V. Zemlyaniy |
author_sort |
Ya. V. Zemlyaniy |
title |
Dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the candesartan and ramipril therapy in patients with heart failure with preserved ejection fraction after myocardial infarction on the background of arter |
title_short |
Dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the candesartan and ramipril therapy in patients with heart failure with preserved ejection fraction after myocardial infarction on the background of arter |
title_full |
Dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the candesartan and ramipril therapy in patients with heart failure with preserved ejection fraction after myocardial infarction on the background of arter |
title_fullStr |
Dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the candesartan and ramipril therapy in patients with heart failure with preserved ejection fraction after myocardial infarction on the background of arter |
title_full_unstemmed |
Dynamics of structural and functional changes of the heart and the levels of GDF 15 and NTproBNP on the candesartan and ramipril therapy in patients with heart failure with preserved ejection fraction after myocardial infarction on the background of arter |
title_sort |
dynamics of structural and functional changes of the heart and the levels of gdf 15 and ntprobnp on the candesartan and ramipril therapy in patients with heart failure with preserved ejection fraction after myocardial infarction on the background of arter |
publisher |
Zaporozhye State Medical University |
publishDate |
2014 |
url |
https://doi.org/10.14739/2310-1210.2014.2.25232 https://doaj.org/article/cea30edf50f14098ae1a544d25be9723 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Zaporožskij Medicinskij Žurnal, Iss 2, Pp 13-17 (2014) |
op_relation |
http://zmj.zsmu.edu.ua/article/view/25232/22652 https://doaj.org/toc/2306-4145 https://doaj.org/toc/2310-1210 doi:10.14739/2310-1210.2014.2.25232 2306-4145 2310-1210 https://doaj.org/article/cea30edf50f14098ae1a544d25be9723 |
op_doi |
https://doi.org/10.14739/2310-1210.2014.2.25232 |
container_title |
Zaporozhye Medical Journal |
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0 |
container_issue |
2 |
_version_ |
1766043428965056512 |