Strongyloides stercoralis infection induces gut dysbiosis in chronic kidney disease patients.
Background Strongyloides stercoralis infection typically causes severe symptoms in immunocompromised patients. This infection can also alter the gut microbiota and is often found in areas where chronic kidney disease (CKD) is common. However, the relationship between S. stercoralis and the gut micro...
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ftdoajarticles:oai:doaj.org/article:ce82e8c09b99488e94d337d280c4b982 2023-05-15T15:14:29+02:00 Strongyloides stercoralis infection induces gut dysbiosis in chronic kidney disease patients. Nguyen Thi Hai Nuttanan Hongsrichan Kitti Intuyod Porntip Pinlaor Manachai Yingklang Apisit Chaidee Thatsanapong Pongking Sirirat Anutrakulchai Ubon Cha'on Somchai Pinlaor 2022-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010302 https://doaj.org/article/ce82e8c09b99488e94d337d280c4b982 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010302 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010302 https://doaj.org/article/ce82e8c09b99488e94d337d280c4b982 PLoS Neglected Tropical Diseases, Vol 16, Iss 9, p e0010302 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010302 2022-12-30T21:56:25Z Background Strongyloides stercoralis infection typically causes severe symptoms in immunocompromised patients. This infection can also alter the gut microbiota and is often found in areas where chronic kidney disease (CKD) is common. However, the relationship between S. stercoralis and the gut microbiome in chronic kidney disease (CKD) is not understood fully. Recent studies have shown that gut dysbiosis plays an important role in the progression of CKD. Hence, this study aims to investigate the association of S. stercoralis infection and gut microbiome in CKD patients. Methodology/principal findings Among 838 volunteers from Khon Kaen Province, northeastern Thailand, 40 subjects with CKD were enrolled and divided into two groups (S. stercoralis-infected and -uninfected) matched for age, sex and biochemical parameters. Next-generation technology was used to amplify and sequence the V3-V4 region of the 16S rRNA gene to provide a profile of the gut microbiota. Results revealed that members of the S. stercoralis-infected group had lower gut microbial diversity than was seen in the uninfected group. Interestingly, there was significantly greater representation of some pathogenic bacteria in the S. stercoralis-infected CKD group, including Escherichia-Shigella (P = 0.013), Rothia (P = 0.013) and Aggregatibacter (P = 0.03). There was also a trend towards increased Actinomyces, Streptococcus and Haemophilus (P > 0.05) in this group. On the other hand, the S. stercoralis-infected CKD group had significantly lower representation of SCFA-producing bacteria such as Anaerostipes (P = 0.01), Coprococcus_1 (0.043) and a non-significant decrease of Akkermansia, Eubacterium rectale and Eubacterium hallii (P > 0.05) relative to the uninfected group. Interesting, the genera Escherichia-Shigella and Anaerostipes exhibited opposing trends, which were significantly related to sex, age, infection status and CKD stages. The genus Escherichia-Shigella was significantly more abundant in CKD patients over the age of 65 years and ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 9 e0010302 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Nguyen Thi Hai Nuttanan Hongsrichan Kitti Intuyod Porntip Pinlaor Manachai Yingklang Apisit Chaidee Thatsanapong Pongking Sirirat Anutrakulchai Ubon Cha'on Somchai Pinlaor Strongyloides stercoralis infection induces gut dysbiosis in chronic kidney disease patients. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Strongyloides stercoralis infection typically causes severe symptoms in immunocompromised patients. This infection can also alter the gut microbiota and is often found in areas where chronic kidney disease (CKD) is common. However, the relationship between S. stercoralis and the gut microbiome in chronic kidney disease (CKD) is not understood fully. Recent studies have shown that gut dysbiosis plays an important role in the progression of CKD. Hence, this study aims to investigate the association of S. stercoralis infection and gut microbiome in CKD patients. Methodology/principal findings Among 838 volunteers from Khon Kaen Province, northeastern Thailand, 40 subjects with CKD were enrolled and divided into two groups (S. stercoralis-infected and -uninfected) matched for age, sex and biochemical parameters. Next-generation technology was used to amplify and sequence the V3-V4 region of the 16S rRNA gene to provide a profile of the gut microbiota. Results revealed that members of the S. stercoralis-infected group had lower gut microbial diversity than was seen in the uninfected group. Interestingly, there was significantly greater representation of some pathogenic bacteria in the S. stercoralis-infected CKD group, including Escherichia-Shigella (P = 0.013), Rothia (P = 0.013) and Aggregatibacter (P = 0.03). There was also a trend towards increased Actinomyces, Streptococcus and Haemophilus (P > 0.05) in this group. On the other hand, the S. stercoralis-infected CKD group had significantly lower representation of SCFA-producing bacteria such as Anaerostipes (P = 0.01), Coprococcus_1 (0.043) and a non-significant decrease of Akkermansia, Eubacterium rectale and Eubacterium hallii (P > 0.05) relative to the uninfected group. Interesting, the genera Escherichia-Shigella and Anaerostipes exhibited opposing trends, which were significantly related to sex, age, infection status and CKD stages. The genus Escherichia-Shigella was significantly more abundant in CKD patients over the age of 65 years and ... |
format |
Article in Journal/Newspaper |
author |
Nguyen Thi Hai Nuttanan Hongsrichan Kitti Intuyod Porntip Pinlaor Manachai Yingklang Apisit Chaidee Thatsanapong Pongking Sirirat Anutrakulchai Ubon Cha'on Somchai Pinlaor |
author_facet |
Nguyen Thi Hai Nuttanan Hongsrichan Kitti Intuyod Porntip Pinlaor Manachai Yingklang Apisit Chaidee Thatsanapong Pongking Sirirat Anutrakulchai Ubon Cha'on Somchai Pinlaor |
author_sort |
Nguyen Thi Hai |
title |
Strongyloides stercoralis infection induces gut dysbiosis in chronic kidney disease patients. |
title_short |
Strongyloides stercoralis infection induces gut dysbiosis in chronic kidney disease patients. |
title_full |
Strongyloides stercoralis infection induces gut dysbiosis in chronic kidney disease patients. |
title_fullStr |
Strongyloides stercoralis infection induces gut dysbiosis in chronic kidney disease patients. |
title_full_unstemmed |
Strongyloides stercoralis infection induces gut dysbiosis in chronic kidney disease patients. |
title_sort |
strongyloides stercoralis infection induces gut dysbiosis in chronic kidney disease patients. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010302 https://doaj.org/article/ce82e8c09b99488e94d337d280c4b982 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 9, p e0010302 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010302 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010302 https://doaj.org/article/ce82e8c09b99488e94d337d280c4b982 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010302 |
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PLOS Neglected Tropical Diseases |
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16 |
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9 |
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e0010302 |
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