Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage
A high sperm DNA fragmentation index (DFI) is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and free radical scavenger, could thus impact semen quality and fertility. The assoc...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:ce7c78637d334d099601cd742231854c 2023-05-15T14:59:14+02:00 Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage Gunilla Malm Trine B Haugen Lars Rylander Aleksander Giwercman 2017-01-01T00:00:00Z https://doi.org/10.4103/1008-682X.186870 https://doaj.org/article/ce7c78637d334d099601cd742231854c EN eng Wolters Kluwer Medknow Publications http://www.ajandrology.com/article.asp?issn=1008-682X;year=2017;volume=19;issue=1;spage=52;epage=56;aulast=Malm https://doaj.org/toc/1008-682X https://doaj.org/toc/1745-7262 1008-682X 1745-7262 doi:10.4103/1008-682X.186870 https://doaj.org/article/ce7c78637d334d099601cd742231854c Asian Journal of Andrology, Vol 19, Iss 1, Pp 52-56 (2017) male infertility melatonin semen quality sperm DNA index Diseases of the genitourinary system. Urology RC870-923 article 2017 ftdoajarticles https://doi.org/10.4103/1008-682X.186870 2022-12-30T23:54:43Z A high sperm DNA fragmentation index (DFI) is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and free radical scavenger, could thus impact semen quality and fertility. The association between the major melatonin metabolite, urine 6-sulfatoxymelatonin (aMT6s), and DFI was analyzed in 110 Oslo men (south of the Arctic Circle) and 86 Tromsoe men (north of the Arctic Circle). Two semen analyses, summer and winter, and four urine samples (early/late summer; early/late winter), were analyzed. The associations between aMT6s in urine and DFI were characterized in a cross-sectional and longitudinal manner using correlation analysis and linear regression. Regardless of season and location, no significant correlations between aMT6s and DFI were observed. The correlation coefficients for associations between changes over time (early winter-early summer) in aMT6s and DFI were for the total cohort: rho = −0.08 (P = 0.322), for the Oslo cohort: rho = −0.07 (P = 0.485), and for the Tromsoe cohort: rho = −0.14 (P = 0.273), respectively. Similar results were seen when comparing late winter and late summer. There was no any statistically significant correlation between changes over time in aMT6s and DFI for men with DFI below and above the median value (10%), respectively. The seasonal variation in melatonin excretion seems not to have any impact on DFI. Article in Journal/Newspaper Arctic Tromsoe Directory of Open Access Journals: DOAJ Articles Arctic Rho ENVELOPE(-63.000,-63.000,-64.300,-64.300) Asian Journal of Andrology 0 0 0 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
male infertility melatonin semen quality sperm DNA index Diseases of the genitourinary system. Urology RC870-923 |
spellingShingle |
male infertility melatonin semen quality sperm DNA index Diseases of the genitourinary system. Urology RC870-923 Gunilla Malm Trine B Haugen Lars Rylander Aleksander Giwercman Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
topic_facet |
male infertility melatonin semen quality sperm DNA index Diseases of the genitourinary system. Urology RC870-923 |
description |
A high sperm DNA fragmentation index (DFI) is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and free radical scavenger, could thus impact semen quality and fertility. The association between the major melatonin metabolite, urine 6-sulfatoxymelatonin (aMT6s), and DFI was analyzed in 110 Oslo men (south of the Arctic Circle) and 86 Tromsoe men (north of the Arctic Circle). Two semen analyses, summer and winter, and four urine samples (early/late summer; early/late winter), were analyzed. The associations between aMT6s in urine and DFI were characterized in a cross-sectional and longitudinal manner using correlation analysis and linear regression. Regardless of season and location, no significant correlations between aMT6s and DFI were observed. The correlation coefficients for associations between changes over time (early winter-early summer) in aMT6s and DFI were for the total cohort: rho = −0.08 (P = 0.322), for the Oslo cohort: rho = −0.07 (P = 0.485), and for the Tromsoe cohort: rho = −0.14 (P = 0.273), respectively. Similar results were seen when comparing late winter and late summer. There was no any statistically significant correlation between changes over time in aMT6s and DFI for men with DFI below and above the median value (10%), respectively. The seasonal variation in melatonin excretion seems not to have any impact on DFI. |
format |
Article in Journal/Newspaper |
author |
Gunilla Malm Trine B Haugen Lars Rylander Aleksander Giwercman |
author_facet |
Gunilla Malm Trine B Haugen Lars Rylander Aleksander Giwercman |
author_sort |
Gunilla Malm |
title |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_short |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_full |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_fullStr |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_full_unstemmed |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_sort |
seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm dna damage |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2017 |
url |
https://doi.org/10.4103/1008-682X.186870 https://doaj.org/article/ce7c78637d334d099601cd742231854c |
long_lat |
ENVELOPE(-63.000,-63.000,-64.300,-64.300) |
geographic |
Arctic Rho |
geographic_facet |
Arctic Rho |
genre |
Arctic Tromsoe |
genre_facet |
Arctic Tromsoe |
op_source |
Asian Journal of Andrology, Vol 19, Iss 1, Pp 52-56 (2017) |
op_relation |
http://www.ajandrology.com/article.asp?issn=1008-682X;year=2017;volume=19;issue=1;spage=52;epage=56;aulast=Malm https://doaj.org/toc/1008-682X https://doaj.org/toc/1745-7262 1008-682X 1745-7262 doi:10.4103/1008-682X.186870 https://doaj.org/article/ce7c78637d334d099601cd742231854c |
op_doi |
https://doi.org/10.4103/1008-682X.186870 |
container_title |
Asian Journal of Andrology |
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container_issue |
0 |
container_start_page |
0 |
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1766331360822165504 |