Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India.
Asymptomatic leishmaniasis may drive the epidemic and an important challenge to reach the goal of joint Visceral Leishmaniasis (VL) elimination initiative taken by three Asian countries. The role of these asymptomatic carriers in disease transmission, prognosis at individual level and rate of transf...
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ftdoajarticles:oai:doaj.org/article:ce43cb74c9f340a4a1392aad0c528a43 2023-05-15T15:12:32+02:00 Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India. Pabitra Saha Swagata Ganguly Moytrey Chatterjee Soumendu Bikash Das Pratip K Kundu Subhasish K Guha Tamal K Ghosh Dilip K Bera Nandita Basu Ardhendu K Maji 2017-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005391 https://doaj.org/article/ce43cb74c9f340a4a1392aad0c528a43 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5322936?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005391 https://doaj.org/article/ce43cb74c9f340a4a1392aad0c528a43 PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005391 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005391 2022-12-31T10:18:07Z Asymptomatic leishmaniasis may drive the epidemic and an important challenge to reach the goal of joint Visceral Leishmaniasis (VL) elimination initiative taken by three Asian countries. The role of these asymptomatic carriers in disease transmission, prognosis at individual level and rate of transformation to symptomatic VL/Post Kala-azar Dermal Leishmaniasis (PKDL) needs to be evaluated. Asymptomatic cases were diagnosed by active mass survey in eight tribal villages by detecting antileishmanial antibody using rK39 based rapid diagnostic kits and followed up for three years to observe the pattern of sero-conversion and disease transformation. Out of 2890 total population, 2603 were screened. Antileishmanial antibody was detected in 185 individuals of them 96 had a history of VL/PKDL and 89 without such history. Seventy nine such individuals were classified as asymptomatic leishmaniasis and ten as active VL with a ratio of 7.9:1. Out of 79 asymptomatic cases 2 were lost to follow up as they moved to other places. Amongst asymptomatically infected persons, disease transformation in 8/77 (10.39%) and sero-conversion in 62/77 (80.52%) cases were noted. Seven (9.09%) remained sero-positive even after three years. Progression to clinical disease among asymptomatic individuals was taking place at any time up to three years after the baseline survey. If there are no VL /PKDL cases for two or more years, it does not mean that the area is free from leishmaniasis as symptomatic VL or PKDL may appear even after three years, if there are such asymptomatic cases. So, asymptomatic infected individuals need much attention for VL elimination programme that has been initiated by three adjoining endemic countries. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Azar ENVELOPE(-63.733,-63.733,-64.983,-64.983) PLOS Neglected Tropical Diseases 11 2 e0005391 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
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language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Pabitra Saha Swagata Ganguly Moytrey Chatterjee Soumendu Bikash Das Pratip K Kundu Subhasish K Guha Tamal K Ghosh Dilip K Bera Nandita Basu Ardhendu K Maji Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Asymptomatic leishmaniasis may drive the epidemic and an important challenge to reach the goal of joint Visceral Leishmaniasis (VL) elimination initiative taken by three Asian countries. The role of these asymptomatic carriers in disease transmission, prognosis at individual level and rate of transformation to symptomatic VL/Post Kala-azar Dermal Leishmaniasis (PKDL) needs to be evaluated. Asymptomatic cases were diagnosed by active mass survey in eight tribal villages by detecting antileishmanial antibody using rK39 based rapid diagnostic kits and followed up for three years to observe the pattern of sero-conversion and disease transformation. Out of 2890 total population, 2603 were screened. Antileishmanial antibody was detected in 185 individuals of them 96 had a history of VL/PKDL and 89 without such history. Seventy nine such individuals were classified as asymptomatic leishmaniasis and ten as active VL with a ratio of 7.9:1. Out of 79 asymptomatic cases 2 were lost to follow up as they moved to other places. Amongst asymptomatically infected persons, disease transformation in 8/77 (10.39%) and sero-conversion in 62/77 (80.52%) cases were noted. Seven (9.09%) remained sero-positive even after three years. Progression to clinical disease among asymptomatic individuals was taking place at any time up to three years after the baseline survey. If there are no VL /PKDL cases for two or more years, it does not mean that the area is free from leishmaniasis as symptomatic VL or PKDL may appear even after three years, if there are such asymptomatic cases. So, asymptomatic infected individuals need much attention for VL elimination programme that has been initiated by three adjoining endemic countries. |
format |
Article in Journal/Newspaper |
author |
Pabitra Saha Swagata Ganguly Moytrey Chatterjee Soumendu Bikash Das Pratip K Kundu Subhasish K Guha Tamal K Ghosh Dilip K Bera Nandita Basu Ardhendu K Maji |
author_facet |
Pabitra Saha Swagata Ganguly Moytrey Chatterjee Soumendu Bikash Das Pratip K Kundu Subhasish K Guha Tamal K Ghosh Dilip K Bera Nandita Basu Ardhendu K Maji |
author_sort |
Pabitra Saha |
title |
Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India. |
title_short |
Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India. |
title_full |
Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India. |
title_fullStr |
Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India. |
title_full_unstemmed |
Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India. |
title_sort |
asymptomatic leishmaniasis in kala-azar endemic areas of malda district, west bengal, india. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005391 https://doaj.org/article/ce43cb74c9f340a4a1392aad0c528a43 |
long_lat |
ENVELOPE(-63.733,-63.733,-64.983,-64.983) |
geographic |
Arctic Azar |
geographic_facet |
Arctic Azar |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005391 (2017) |
op_relation |
http://europepmc.org/articles/PMC5322936?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005391 https://doaj.org/article/ce43cb74c9f340a4a1392aad0c528a43 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005391 |
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PLOS Neglected Tropical Diseases |
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11 |
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2 |
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e0005391 |
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