Transmission and containment of the SARS-CoV-2 Delta variant of concern in Guangzhou, China: A population-based study
Background The first community transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant of concern (VOC) in Guangzhou, China occurred between May and June 2021. Herein, we describe the epidemiological characteristics of this outbreak and evaluate the implemented...
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ftdoajarticles:oai:doaj.org/article:ce3dabd48b574403be28c105a16ee9a8 2023-05-15T15:15:11+02:00 Transmission and containment of the SARS-CoV-2 Delta variant of concern in Guangzhou, China: A population-based study Li Li Zhi-Gang Han Peng-Zhe Qin Wen-Hui Liu Zhou Yang Zong-Qiu Chen Ke Li Chao-Jun Xie Yu Ma Hui Wang Yong Huang Shu-Jun Fan Ze-Lin Yan Chun-Quan Ou Lei Luo 2022-01-01T00:00:00Z https://doaj.org/article/ce3dabd48b574403be28c105a16ee9a8 EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730460/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 https://doaj.org/article/ce3dabd48b574403be28c105a16ee9a8 PLoS Neglected Tropical Diseases, Vol 16, Iss 1 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles 2022-12-31T08:08:54Z Background The first community transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant of concern (VOC) in Guangzhou, China occurred between May and June 2021. Herein, we describe the epidemiological characteristics of this outbreak and evaluate the implemented containment measures against this outbreak. Methodology/Principal findings Guangzhou Center for Disease Control and Prevention provided the data on SARS-CoV-2 infections reported between 21 May and 24 June 2021. We estimated the incubation period distribution by fitting a gamma distribution to the data, while the serial interval distribution was estimated by fitting a normal distribution. The instantaneous effective reproductive number (Rt) was estimated to reflect the transmissibility of SARS-CoV-2. Clinical severity was compared for cases with different vaccination statuses using an ordinal regression model after controlling for age. Of the reported local cases, 7/153 (4.6%) were asymptomatic. The median incubation period was 6.02 (95% confidence interval [CI]: 5.42–6.71) days and the means of serial intervals decreased from 5.19 (95% CI: 4.29–6.11) to 3.78 (95% CI: 2.74–4.81) days. The incubation period increased with age (P<0.001). A hierarchical prevention and control strategy against COVID-19 was implemented in Guangzhou, with Rt decreasing from 6.83 (95% credible interval [CrI]: 3.98–10.44) for the 7-day time window ending on 27 May 2021 to below 1 for the time window ending on 8 June and thereafter. Individuals with partial or full vaccination schedules with BBIBP-CorV or CoronaVac accounted for 15.3% of the COVID-19 cases. Clinical symptoms were milder in partially or fully vaccinated cases than in unvaccinated cases (odds ratio [OR] = 0.26 [95% CI: 0.07–0.94]). Conclusions/Significance The hierarchical prevention and control strategy against COVID-19 in Guangzhou was timely and effective. Authorised inactivated vaccines are likely to contribute to reducing the probability of developing severe disease. ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Li Li Zhi-Gang Han Peng-Zhe Qin Wen-Hui Liu Zhou Yang Zong-Qiu Chen Ke Li Chao-Jun Xie Yu Ma Hui Wang Yong Huang Shu-Jun Fan Ze-Lin Yan Chun-Quan Ou Lei Luo Transmission and containment of the SARS-CoV-2 Delta variant of concern in Guangzhou, China: A population-based study |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background The first community transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant of concern (VOC) in Guangzhou, China occurred between May and June 2021. Herein, we describe the epidemiological characteristics of this outbreak and evaluate the implemented containment measures against this outbreak. Methodology/Principal findings Guangzhou Center for Disease Control and Prevention provided the data on SARS-CoV-2 infections reported between 21 May and 24 June 2021. We estimated the incubation period distribution by fitting a gamma distribution to the data, while the serial interval distribution was estimated by fitting a normal distribution. The instantaneous effective reproductive number (Rt) was estimated to reflect the transmissibility of SARS-CoV-2. Clinical severity was compared for cases with different vaccination statuses using an ordinal regression model after controlling for age. Of the reported local cases, 7/153 (4.6%) were asymptomatic. The median incubation period was 6.02 (95% confidence interval [CI]: 5.42–6.71) days and the means of serial intervals decreased from 5.19 (95% CI: 4.29–6.11) to 3.78 (95% CI: 2.74–4.81) days. The incubation period increased with age (P<0.001). A hierarchical prevention and control strategy against COVID-19 was implemented in Guangzhou, with Rt decreasing from 6.83 (95% credible interval [CrI]: 3.98–10.44) for the 7-day time window ending on 27 May 2021 to below 1 for the time window ending on 8 June and thereafter. Individuals with partial or full vaccination schedules with BBIBP-CorV or CoronaVac accounted for 15.3% of the COVID-19 cases. Clinical symptoms were milder in partially or fully vaccinated cases than in unvaccinated cases (odds ratio [OR] = 0.26 [95% CI: 0.07–0.94]). Conclusions/Significance The hierarchical prevention and control strategy against COVID-19 in Guangzhou was timely and effective. Authorised inactivated vaccines are likely to contribute to reducing the probability of developing severe disease. ... |
format |
Article in Journal/Newspaper |
author |
Li Li Zhi-Gang Han Peng-Zhe Qin Wen-Hui Liu Zhou Yang Zong-Qiu Chen Ke Li Chao-Jun Xie Yu Ma Hui Wang Yong Huang Shu-Jun Fan Ze-Lin Yan Chun-Quan Ou Lei Luo |
author_facet |
Li Li Zhi-Gang Han Peng-Zhe Qin Wen-Hui Liu Zhou Yang Zong-Qiu Chen Ke Li Chao-Jun Xie Yu Ma Hui Wang Yong Huang Shu-Jun Fan Ze-Lin Yan Chun-Quan Ou Lei Luo |
author_sort |
Li Li |
title |
Transmission and containment of the SARS-CoV-2 Delta variant of concern in Guangzhou, China: A population-based study |
title_short |
Transmission and containment of the SARS-CoV-2 Delta variant of concern in Guangzhou, China: A population-based study |
title_full |
Transmission and containment of the SARS-CoV-2 Delta variant of concern in Guangzhou, China: A population-based study |
title_fullStr |
Transmission and containment of the SARS-CoV-2 Delta variant of concern in Guangzhou, China: A population-based study |
title_full_unstemmed |
Transmission and containment of the SARS-CoV-2 Delta variant of concern in Guangzhou, China: A population-based study |
title_sort |
transmission and containment of the sars-cov-2 delta variant of concern in guangzhou, china: a population-based study |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doaj.org/article/ce3dabd48b574403be28c105a16ee9a8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 1 (2022) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730460/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 https://doaj.org/article/ce3dabd48b574403be28c105a16ee9a8 |
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1766345563571224576 |