Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention
Community-driven projects have characterized Helicobacter pylori ( Hp ) infection in Indigenous communities in the Northwest Territories (NT) and Yukon (YT), Canada. These projects address concerns about the frequent diagnosis of Hp infection among community members and its relation to gastric cance...
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ftdoajarticles:oai:doaj.org/article:cdedce9596114e17ab5717032ffd2fb9 2023-09-05T13:17:14+02:00 Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention Ting Wang Safwat Girgis Hsiu-Ju Chang Ali Assi Katharine Fagan-Garcia Taylor Cromarty Rachel Munday Karen J. Goodman Sander Veldhuyzen van Zanten the CANHelp Working Group 2023-08-01T00:00:00Z https://doi.org/10.3390/cancers15153950 https://doaj.org/article/cdedce9596114e17ab5717032ffd2fb9 EN eng MDPI AG https://www.mdpi.com/2072-6694/15/15/3950 https://doaj.org/toc/2072-6694 doi:10.3390/cancers15153950 2072-6694 https://doaj.org/article/cdedce9596114e17ab5717032ffd2fb9 Cancers, Vol 15, Iss 3950, p 3950 (2023) Helicobacter pylori Arctic Canada indigenous health gastritis active gastritis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 article 2023 ftdoajarticles https://doi.org/10.3390/cancers15153950 2023-08-13T00:35:04Z Community-driven projects have characterized Helicobacter pylori ( Hp ) infection in Indigenous communities in the Northwest Territories (NT) and Yukon (YT), Canada. These projects address concerns about the frequent diagnosis of Hp infection among community members and its relation to gastric cancer deaths, perceived to occur with alarming frequency in this region. Projects included breath-test screening for Hp infection, gastroscopy with gastric biopsies, and treatment to eliminate Hp infection. Previous project results showed a high prevalence of stomach pathologies associated with increased cancer risk among Hp -positive participants at baseline. This analysis describes changes in precancerous gastric pathologies in project participants who had gastroscopy before baseline treatment during 2008–2013 and again in 2017. Throughout the study period, the same pathologist graded Hp density, active gastritis, chronic gastritis, atrophic gastritis, and intestinal metaplasia using the updated Sydney System. Of 310 participants from three communities with baseline pathology data, 69 had follow-up pathology data. Relative to baseline, the prevalence of Hp infection and precancerous gastric pathology was substantially lower at follow-up; most participants who were Hp -positive at baseline and Hp -negative at follow-up had reduced severity of active, chronic, and/or atrophic gastritis at follow-up. Though follow-up numbers are small, these results yield evidence that successful Hp treatment has the potential to reduce the risk of gastric cancer in Arctic Indigenous communities. Article in Journal/Newspaper Arctic Northwest Territories Yukon Directory of Open Access Journals: DOAJ Articles Arctic Canada Northwest Territories Yukon Cancers 15 15 3950 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Helicobacter pylori Arctic Canada indigenous health gastritis active gastritis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
spellingShingle |
Helicobacter pylori Arctic Canada indigenous health gastritis active gastritis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ting Wang Safwat Girgis Hsiu-Ju Chang Ali Assi Katharine Fagan-Garcia Taylor Cromarty Rachel Munday Karen J. Goodman Sander Veldhuyzen van Zanten the CANHelp Working Group Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention |
topic_facet |
Helicobacter pylori Arctic Canada indigenous health gastritis active gastritis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
description |
Community-driven projects have characterized Helicobacter pylori ( Hp ) infection in Indigenous communities in the Northwest Territories (NT) and Yukon (YT), Canada. These projects address concerns about the frequent diagnosis of Hp infection among community members and its relation to gastric cancer deaths, perceived to occur with alarming frequency in this region. Projects included breath-test screening for Hp infection, gastroscopy with gastric biopsies, and treatment to eliminate Hp infection. Previous project results showed a high prevalence of stomach pathologies associated with increased cancer risk among Hp -positive participants at baseline. This analysis describes changes in precancerous gastric pathologies in project participants who had gastroscopy before baseline treatment during 2008–2013 and again in 2017. Throughout the study period, the same pathologist graded Hp density, active gastritis, chronic gastritis, atrophic gastritis, and intestinal metaplasia using the updated Sydney System. Of 310 participants from three communities with baseline pathology data, 69 had follow-up pathology data. Relative to baseline, the prevalence of Hp infection and precancerous gastric pathology was substantially lower at follow-up; most participants who were Hp -positive at baseline and Hp -negative at follow-up had reduced severity of active, chronic, and/or atrophic gastritis at follow-up. Though follow-up numbers are small, these results yield evidence that successful Hp treatment has the potential to reduce the risk of gastric cancer in Arctic Indigenous communities. |
format |
Article in Journal/Newspaper |
author |
Ting Wang Safwat Girgis Hsiu-Ju Chang Ali Assi Katharine Fagan-Garcia Taylor Cromarty Rachel Munday Karen J. Goodman Sander Veldhuyzen van Zanten the CANHelp Working Group |
author_facet |
Ting Wang Safwat Girgis Hsiu-Ju Chang Ali Assi Katharine Fagan-Garcia Taylor Cromarty Rachel Munday Karen J. Goodman Sander Veldhuyzen van Zanten the CANHelp Working Group |
author_sort |
Ting Wang |
title |
Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention |
title_short |
Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention |
title_full |
Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention |
title_fullStr |
Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention |
title_full_unstemmed |
Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention |
title_sort |
changes in gastric pathology after h. pylori treatment in community-driven research aimed at gastric cancer prevention |
publisher |
MDPI AG |
publishDate |
2023 |
url |
https://doi.org/10.3390/cancers15153950 https://doaj.org/article/cdedce9596114e17ab5717032ffd2fb9 |
geographic |
Arctic Canada Northwest Territories Yukon |
geographic_facet |
Arctic Canada Northwest Territories Yukon |
genre |
Arctic Northwest Territories Yukon |
genre_facet |
Arctic Northwest Territories Yukon |
op_source |
Cancers, Vol 15, Iss 3950, p 3950 (2023) |
op_relation |
https://www.mdpi.com/2072-6694/15/15/3950 https://doaj.org/toc/2072-6694 doi:10.3390/cancers15153950 2072-6694 https://doaj.org/article/cdedce9596114e17ab5717032ffd2fb9 |
op_doi |
https://doi.org/10.3390/cancers15153950 |
container_title |
Cancers |
container_volume |
15 |
container_issue |
15 |
container_start_page |
3950 |
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1776198484279427072 |