Association between age and severity to leptospirosis in children.
BACKGROUND: In endemic areas, leptospirosis is more common and more severe in adults compared with children. Reasons to explain this discrepancy remain unclear and limited data focusing on adolescents are available. The objective of the study was to describe disease spectrum and outcome differences...
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ftdoajarticles:oai:doaj.org/article:cdebdaef1d49422da23106dd5b62a3d8 2023-05-15T15:05:24+02:00 Association between age and severity to leptospirosis in children. Gilles Guerrier Pauline Hie Ann-Claire Gourinat Emilie Huguon Yann Polfrit Cyrille Goarant Eric D'Ortenzio Isabelle Missotte 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002436 https://doaj.org/article/cdebdaef1d49422da23106dd5b62a3d8 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3784464?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002436 https://doaj.org/article/cdebdaef1d49422da23106dd5b62a3d8 PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2436 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002436 2022-12-31T00:18:05Z BACKGROUND: In endemic areas, leptospirosis is more common and more severe in adults compared with children. Reasons to explain this discrepancy remain unclear and limited data focusing on adolescents are available. The objective of the study was to describe disease spectrum and outcome differences in children and adolescents admitted for leptospirosis in a large at-risk population. METHODS: Clinical and laboratory data were obtained on hospitalized cases in New Caledonia from 2006 to 2012. RESULTS: Data of 60 patients <18 years of age (25 children under 14 and 35 adolescents aged 14 to 17) with confirmed leptospirosis were analyzed. Compared with children, adolescents presented more often with classic features of Weil disease (p = 0.02), combining hepatic and renal involvement with or without pulmonary participation. Jarisch-Herxheimer reactions were observed more often among adolescents (p<0.01). The overall case fatality rate was low (1 adolescent versus 0 children). CONCLUSION: Severe leptospirosis in adolescents may be more likely to show adults' characteristics compared with children. Further studies are required to explore age-dependant host factors, including puberty-related physiological changes. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 9 e2436 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Gilles Guerrier Pauline Hie Ann-Claire Gourinat Emilie Huguon Yann Polfrit Cyrille Goarant Eric D'Ortenzio Isabelle Missotte Association between age and severity to leptospirosis in children. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: In endemic areas, leptospirosis is more common and more severe in adults compared with children. Reasons to explain this discrepancy remain unclear and limited data focusing on adolescents are available. The objective of the study was to describe disease spectrum and outcome differences in children and adolescents admitted for leptospirosis in a large at-risk population. METHODS: Clinical and laboratory data were obtained on hospitalized cases in New Caledonia from 2006 to 2012. RESULTS: Data of 60 patients <18 years of age (25 children under 14 and 35 adolescents aged 14 to 17) with confirmed leptospirosis were analyzed. Compared with children, adolescents presented more often with classic features of Weil disease (p = 0.02), combining hepatic and renal involvement with or without pulmonary participation. Jarisch-Herxheimer reactions were observed more often among adolescents (p<0.01). The overall case fatality rate was low (1 adolescent versus 0 children). CONCLUSION: Severe leptospirosis in adolescents may be more likely to show adults' characteristics compared with children. Further studies are required to explore age-dependant host factors, including puberty-related physiological changes. |
format |
Article in Journal/Newspaper |
author |
Gilles Guerrier Pauline Hie Ann-Claire Gourinat Emilie Huguon Yann Polfrit Cyrille Goarant Eric D'Ortenzio Isabelle Missotte |
author_facet |
Gilles Guerrier Pauline Hie Ann-Claire Gourinat Emilie Huguon Yann Polfrit Cyrille Goarant Eric D'Ortenzio Isabelle Missotte |
author_sort |
Gilles Guerrier |
title |
Association between age and severity to leptospirosis in children. |
title_short |
Association between age and severity to leptospirosis in children. |
title_full |
Association between age and severity to leptospirosis in children. |
title_fullStr |
Association between age and severity to leptospirosis in children. |
title_full_unstemmed |
Association between age and severity to leptospirosis in children. |
title_sort |
association between age and severity to leptospirosis in children. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002436 https://doaj.org/article/cdebdaef1d49422da23106dd5b62a3d8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2436 (2013) |
op_relation |
http://europepmc.org/articles/PMC3784464?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002436 https://doaj.org/article/cdebdaef1d49422da23106dd5b62a3d8 |
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https://doi.org/10.1371/journal.pntd.0002436 |
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PLoS Neglected Tropical Diseases |
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9 |
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e2436 |
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