Phylogenetic and Geospatial Evidence of Canine Parvovirus Transmission between Wild Dogs and Domestic Dogs at the Urban Fringe in Australia
Canine parvovirus (CPV) is an important cause of disease in domestic dogs. Sporadic cases and outbreaks occur across Australia and worldwide and are associated with high morbidity and mortality. Whether transmission of CPV occurs between owned dogs and populations of wild dogs, including Canis famil...
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ftdoajarticles:oai:doaj.org/article:ccf7c0bfaf1541358c9385a3952f5e13 2023-05-15T15:51:00+02:00 Phylogenetic and Geospatial Evidence of Canine Parvovirus Transmission between Wild Dogs and Domestic Dogs at the Urban Fringe in Australia Mark Kelman Lana Harriott Maura Carrai Emily Kwan Michael P. Ward Vanessa R. Barrs 2020-06-01T00:00:00Z https://doi.org/10.3390/v12060663 https://doaj.org/article/ccf7c0bfaf1541358c9385a3952f5e13 EN eng MDPI AG https://www.mdpi.com/1999-4915/12/6/663 https://doaj.org/toc/1999-4915 doi:10.3390/v12060663 1999-4915 https://doaj.org/article/ccf7c0bfaf1541358c9385a3952f5e13 Viruses, Vol 12, Iss 663, p 663 (2020) canine parvovirus peri-urban wild dogs disease transmission Australia Microbiology QR1-502 article 2020 ftdoajarticles https://doi.org/10.3390/v12060663 2022-12-30T22:21:10Z Canine parvovirus (CPV) is an important cause of disease in domestic dogs. Sporadic cases and outbreaks occur across Australia and worldwide and are associated with high morbidity and mortality. Whether transmission of CPV occurs between owned dogs and populations of wild dogs, including Canis familiaris , Canis lupus dingo and hybrids, is not known. To investigate the role of wild dogs in CPV epidemiology in Australia, PCR was used to detect CPV DNA in tissue from wild dogs culled in the peri-urban regions of two Australian states, between August 2012 and May 2015. CPV DNA was detected in 4.7% (8/170). There was a strong geospatial association between wild-dog CPV infections and domestic-dog CPV cases reported to a national disease surveillance system between 2009 and 2015. Postcodes in which wild dogs tested positive for CPV were 8.63 times more likely to also have domestic-dog cases reported than postcodes in which wild dogs tested negative ( p = 0.0332). Phylogenetic analysis of CPV VP2 sequences from wild dogs showed they were all CPV-2a variants characterized by a novel amino acid mutation (21-Ala) recently identified in CPV isolates from owned dogs in Australia with parvoviral enteritis. Wild-dog CPV VP2 sequences were compared to those from owned domestic dogs in Australia. For one domestic-dog case located approximately 10 km from a wild-dog capture location, and reported 3.5 years after the nearest wild dog was sampled, the virus was demonstrated to have a closely related common ancestor. This study provides phylogenetic and geospatial evidence of CPV transmission between wild and domestic dogs in Australia. Article in Journal/Newspaper Canis lupus Directory of Open Access Journals: DOAJ Articles Viruses 12 6 663 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
canine parvovirus peri-urban wild dogs disease transmission Australia Microbiology QR1-502 |
spellingShingle |
canine parvovirus peri-urban wild dogs disease transmission Australia Microbiology QR1-502 Mark Kelman Lana Harriott Maura Carrai Emily Kwan Michael P. Ward Vanessa R. Barrs Phylogenetic and Geospatial Evidence of Canine Parvovirus Transmission between Wild Dogs and Domestic Dogs at the Urban Fringe in Australia |
topic_facet |
canine parvovirus peri-urban wild dogs disease transmission Australia Microbiology QR1-502 |
description |
Canine parvovirus (CPV) is an important cause of disease in domestic dogs. Sporadic cases and outbreaks occur across Australia and worldwide and are associated with high morbidity and mortality. Whether transmission of CPV occurs between owned dogs and populations of wild dogs, including Canis familiaris , Canis lupus dingo and hybrids, is not known. To investigate the role of wild dogs in CPV epidemiology in Australia, PCR was used to detect CPV DNA in tissue from wild dogs culled in the peri-urban regions of two Australian states, between August 2012 and May 2015. CPV DNA was detected in 4.7% (8/170). There was a strong geospatial association between wild-dog CPV infections and domestic-dog CPV cases reported to a national disease surveillance system between 2009 and 2015. Postcodes in which wild dogs tested positive for CPV were 8.63 times more likely to also have domestic-dog cases reported than postcodes in which wild dogs tested negative ( p = 0.0332). Phylogenetic analysis of CPV VP2 sequences from wild dogs showed they were all CPV-2a variants characterized by a novel amino acid mutation (21-Ala) recently identified in CPV isolates from owned dogs in Australia with parvoviral enteritis. Wild-dog CPV VP2 sequences were compared to those from owned domestic dogs in Australia. For one domestic-dog case located approximately 10 km from a wild-dog capture location, and reported 3.5 years after the nearest wild dog was sampled, the virus was demonstrated to have a closely related common ancestor. This study provides phylogenetic and geospatial evidence of CPV transmission between wild and domestic dogs in Australia. |
format |
Article in Journal/Newspaper |
author |
Mark Kelman Lana Harriott Maura Carrai Emily Kwan Michael P. Ward Vanessa R. Barrs |
author_facet |
Mark Kelman Lana Harriott Maura Carrai Emily Kwan Michael P. Ward Vanessa R. Barrs |
author_sort |
Mark Kelman |
title |
Phylogenetic and Geospatial Evidence of Canine Parvovirus Transmission between Wild Dogs and Domestic Dogs at the Urban Fringe in Australia |
title_short |
Phylogenetic and Geospatial Evidence of Canine Parvovirus Transmission between Wild Dogs and Domestic Dogs at the Urban Fringe in Australia |
title_full |
Phylogenetic and Geospatial Evidence of Canine Parvovirus Transmission between Wild Dogs and Domestic Dogs at the Urban Fringe in Australia |
title_fullStr |
Phylogenetic and Geospatial Evidence of Canine Parvovirus Transmission between Wild Dogs and Domestic Dogs at the Urban Fringe in Australia |
title_full_unstemmed |
Phylogenetic and Geospatial Evidence of Canine Parvovirus Transmission between Wild Dogs and Domestic Dogs at the Urban Fringe in Australia |
title_sort |
phylogenetic and geospatial evidence of canine parvovirus transmission between wild dogs and domestic dogs at the urban fringe in australia |
publisher |
MDPI AG |
publishDate |
2020 |
url |
https://doi.org/10.3390/v12060663 https://doaj.org/article/ccf7c0bfaf1541358c9385a3952f5e13 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Viruses, Vol 12, Iss 663, p 663 (2020) |
op_relation |
https://www.mdpi.com/1999-4915/12/6/663 https://doaj.org/toc/1999-4915 doi:10.3390/v12060663 1999-4915 https://doaj.org/article/ccf7c0bfaf1541358c9385a3952f5e13 |
op_doi |
https://doi.org/10.3390/v12060663 |
container_title |
Viruses |
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12 |
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6 |
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663 |
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1766386037020426240 |