Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rabbits
Objective: To synthesize zinc oxide nanoparticles (ZnONPs) and evaluate their antibacterial and wound healing effects against wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). Methods: ZnONPs were prepared by sol-gel method and characterized by X-ray diffraction (XRD) analysis...
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Wolters Kluwer Medknow Publications
2023
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ftdoajarticles:oai:doaj.org/article:ccc5366eb5ff4dfc89de7a145409fa55 2024-09-09T19:26:32+00:00 Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rabbits Muhammad Asif Ayesha Safdar Chaudhry Ambreen Ashar Hamad Bin Rashid Muhammad Hassan Saleem Hassaan Bin Aslam Abdul Aziz 2023-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.389574 https://doaj.org/article/ccc5366eb5ff4dfc89de7a145409fa55 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=11;spage=488;epage=496;aulast=Asif https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.389574 https://doaj.org/article/ccc5366eb5ff4dfc89de7a145409fa55 Asian Pacific Journal of Tropical Biomedicine, Vol 13, Iss 11, Pp 488-496 (2023) mrsa wound healing zno nanoparticles ointment Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2023 ftdoajarticles https://doi.org/10.4103/2221-1691.389574 2024-08-05T17:49:19Z Objective: To synthesize zinc oxide nanoparticles (ZnONPs) and evaluate their antibacterial and wound healing effects against wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). Methods: ZnONPs were prepared by sol-gel method and characterized by X-ray diffraction (XRD) analysis and scanning electron microscopy (SEM). A total of 18 rabbits were divided into three groups: the ZnONPs group, the gentamicin group and the control group. A wound of 3 cm2 was inflicted on each rabbit and contaminated with MRSA inoculum. Treatment was started from the fourth day post-surgery. Wound healing, microbiological analysis, and histopathological analysis were performed to assess the efficacy of ZnONPs ointment. Results: XRD analysis confirmed the hexagonal wurtzite structure of the ZnONPs with an average crystallite size of 29.23 nm. SEM revealed discoid-shaped ZnONPs with a rough surface and an average size of 48.36 nm. Energy-dispersive X-ray analysis confirmed the purity of ZnONPs. Moreover, the particle size ranged from 100-700 nm with a high agglomeration trend. Treatment with ZnONPs promoted MRSA-infected wound healing. In addition, ZnONPs showed a good antibacterial effect as evidenced by a dose-dependent increase in the zone of inhibition. Conclusions: ZnONPs accelerate the healing of MRSA-infected wounds. Therefore, it can be explored for the treatment of MRSA infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 13 11 488 496 |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
topic |
mrsa wound healing zno nanoparticles ointment Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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mrsa wound healing zno nanoparticles ointment Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Muhammad Asif Ayesha Safdar Chaudhry Ambreen Ashar Hamad Bin Rashid Muhammad Hassan Saleem Hassaan Bin Aslam Abdul Aziz Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rabbits |
topic_facet |
mrsa wound healing zno nanoparticles ointment Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To synthesize zinc oxide nanoparticles (ZnONPs) and evaluate their antibacterial and wound healing effects against wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). Methods: ZnONPs were prepared by sol-gel method and characterized by X-ray diffraction (XRD) analysis and scanning electron microscopy (SEM). A total of 18 rabbits were divided into three groups: the ZnONPs group, the gentamicin group and the control group. A wound of 3 cm2 was inflicted on each rabbit and contaminated with MRSA inoculum. Treatment was started from the fourth day post-surgery. Wound healing, microbiological analysis, and histopathological analysis were performed to assess the efficacy of ZnONPs ointment. Results: XRD analysis confirmed the hexagonal wurtzite structure of the ZnONPs with an average crystallite size of 29.23 nm. SEM revealed discoid-shaped ZnONPs with a rough surface and an average size of 48.36 nm. Energy-dispersive X-ray analysis confirmed the purity of ZnONPs. Moreover, the particle size ranged from 100-700 nm with a high agglomeration trend. Treatment with ZnONPs promoted MRSA-infected wound healing. In addition, ZnONPs showed a good antibacterial effect as evidenced by a dose-dependent increase in the zone of inhibition. Conclusions: ZnONPs accelerate the healing of MRSA-infected wounds. Therefore, it can be explored for the treatment of MRSA infection. |
format |
Article in Journal/Newspaper |
author |
Muhammad Asif Ayesha Safdar Chaudhry Ambreen Ashar Hamad Bin Rashid Muhammad Hassan Saleem Hassaan Bin Aslam Abdul Aziz |
author_facet |
Muhammad Asif Ayesha Safdar Chaudhry Ambreen Ashar Hamad Bin Rashid Muhammad Hassan Saleem Hassaan Bin Aslam Abdul Aziz |
author_sort |
Muhammad Asif |
title |
Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rabbits |
title_short |
Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rabbits |
title_full |
Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rabbits |
title_fullStr |
Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rabbits |
title_full_unstemmed |
Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rabbits |
title_sort |
zinc oxide nanoparticles accelerate the healing of methicillin-resistant staphylococcus aureus (mrsa)-infected wounds in rabbits |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2023 |
url |
https://doi.org/10.4103/2221-1691.389574 https://doaj.org/article/ccc5366eb5ff4dfc89de7a145409fa55 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 13, Iss 11, Pp 488-496 (2023) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=11;spage=488;epage=496;aulast=Asif https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.389574 https://doaj.org/article/ccc5366eb5ff4dfc89de7a145409fa55 |
op_doi |
https://doi.org/10.4103/2221-1691.389574 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
13 |
container_issue |
11 |
container_start_page |
488 |
op_container_end_page |
496 |
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1809896134585352192 |