Glatiramer acetate reduces the risk for experimental cerebral malaria: a pilot study
Abstract Background Cerebral malaria (CM) is associated with high mortality and morbidity caused by a high rate of transient or persistent neurological sequelae. Studies on immunomodulatory and neuroprotective drugs as ancillary treatment in murine CM indicate promising potential. The current study...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2009
|
Subjects: | |
Online Access: | https://doi.org/10.1186/1475-2875-8-36 https://doaj.org/article/ccb7ad57162e451d9e0711e2d26bcccc |
id |
ftdoajarticles:oai:doaj.org/article:ccb7ad57162e451d9e0711e2d26bcccc |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:ccb7ad57162e451d9e0711e2d26bcccc 2023-05-15T15:07:27+02:00 Glatiramer acetate reduces the risk for experimental cerebral malaria: a pilot study Helbok Raimund Broessner Gregor Dietmann Anelia Burger Christoph Part Andrea Lackner Peter Reindl Markus Schmutzhard Erich Beer Ronny 2009-02-01T00:00:00Z https://doi.org/10.1186/1475-2875-8-36 https://doaj.org/article/ccb7ad57162e451d9e0711e2d26bcccc EN eng BMC http://www.malariajournal.com/content/8/1/36 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-36 1475-2875 https://doaj.org/article/ccb7ad57162e451d9e0711e2d26bcccc Malaria Journal, Vol 8, Iss 1, p 36 (2009) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2009 ftdoajarticles https://doi.org/10.1186/1475-2875-8-36 2022-12-31T13:08:57Z Abstract Background Cerebral malaria (CM) is associated with high mortality and morbidity caused by a high rate of transient or persistent neurological sequelae. Studies on immunomodulatory and neuroprotective drugs as ancillary treatment in murine CM indicate promising potential. The current study was conducted to evaluate the efficacy of glatiramer acetate (GA), an immunomodulatory drug approved for the treatment of relapsing remitting multiple sclerosis, in preventing the death of C57Bl/6J mice infected with Plasmodium berghei ANKA. Methods and Results GA treatment led to a statistically significant lower risk for developing CM (57.7% versus 84.6%) in treated animals. The drug had no effect on the course of parasitaemia. The mechanism of action seems to be an immunomodulatory effect since lower IFN-gamma levels were observed in treated animals in the early course of the disease (day 4 post-infection) which also led to a lower number of brain sequestered leukocytes in treated animals. No direct neuro-protective effect such as an inhibition of apoptosis or reduction of micro-bleedings in the brain was found. Conclusion These findings support the important role of the host immune response in the pathophysiology of murine CM and might lead to the development of new adjunctive treatment strategies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 8 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Helbok Raimund Broessner Gregor Dietmann Anelia Burger Christoph Part Andrea Lackner Peter Reindl Markus Schmutzhard Erich Beer Ronny Glatiramer acetate reduces the risk for experimental cerebral malaria: a pilot study |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Cerebral malaria (CM) is associated with high mortality and morbidity caused by a high rate of transient or persistent neurological sequelae. Studies on immunomodulatory and neuroprotective drugs as ancillary treatment in murine CM indicate promising potential. The current study was conducted to evaluate the efficacy of glatiramer acetate (GA), an immunomodulatory drug approved for the treatment of relapsing remitting multiple sclerosis, in preventing the death of C57Bl/6J mice infected with Plasmodium berghei ANKA. Methods and Results GA treatment led to a statistically significant lower risk for developing CM (57.7% versus 84.6%) in treated animals. The drug had no effect on the course of parasitaemia. The mechanism of action seems to be an immunomodulatory effect since lower IFN-gamma levels were observed in treated animals in the early course of the disease (day 4 post-infection) which also led to a lower number of brain sequestered leukocytes in treated animals. No direct neuro-protective effect such as an inhibition of apoptosis or reduction of micro-bleedings in the brain was found. Conclusion These findings support the important role of the host immune response in the pathophysiology of murine CM and might lead to the development of new adjunctive treatment strategies. |
format |
Article in Journal/Newspaper |
author |
Helbok Raimund Broessner Gregor Dietmann Anelia Burger Christoph Part Andrea Lackner Peter Reindl Markus Schmutzhard Erich Beer Ronny |
author_facet |
Helbok Raimund Broessner Gregor Dietmann Anelia Burger Christoph Part Andrea Lackner Peter Reindl Markus Schmutzhard Erich Beer Ronny |
author_sort |
Helbok Raimund |
title |
Glatiramer acetate reduces the risk for experimental cerebral malaria: a pilot study |
title_short |
Glatiramer acetate reduces the risk for experimental cerebral malaria: a pilot study |
title_full |
Glatiramer acetate reduces the risk for experimental cerebral malaria: a pilot study |
title_fullStr |
Glatiramer acetate reduces the risk for experimental cerebral malaria: a pilot study |
title_full_unstemmed |
Glatiramer acetate reduces the risk for experimental cerebral malaria: a pilot study |
title_sort |
glatiramer acetate reduces the risk for experimental cerebral malaria: a pilot study |
publisher |
BMC |
publishDate |
2009 |
url |
https://doi.org/10.1186/1475-2875-8-36 https://doaj.org/article/ccb7ad57162e451d9e0711e2d26bcccc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 8, Iss 1, p 36 (2009) |
op_relation |
http://www.malariajournal.com/content/8/1/36 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-36 1475-2875 https://doaj.org/article/ccb7ad57162e451d9e0711e2d26bcccc |
op_doi |
https://doi.org/10.1186/1475-2875-8-36 |
container_title |
Malaria Journal |
container_volume |
8 |
container_issue |
1 |
_version_ |
1766338958667546624 |