"Kankasha" in Kassala: A prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan.
Background The public health impact of Chikungunya virus (CHIKV) is often underestimated. Usually considered a mild condition of short duration, recent outbreaks have reported greater incidence of severe illness, fatality, and longer-term disability. In 2018/19, Eastern Sudan experienced the largest...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0009387 https://doaj.org/article/cc6646bf211b4466b1167ed4beff6a79 |
id |
ftdoajarticles:oai:doaj.org/article:cc6646bf211b4466b1167ed4beff6a79 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:cc6646bf211b4466b1167ed4beff6a79 2023-05-15T15:14:09+02:00 "Kankasha" in Kassala: A prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan. Hilary Bower Mubarak El Karsany Abd Alhadi Adam Hussein Adam Mubarak Ibrahim Idriss Ma'aaza Abasher Alzain Mohamed Elamin Ahmed Alfakiyousif Rehab Mohamed Iman Mahmoud Omer Albadri Suha Abdulaziz Alnour Mahmoud Orwa Ibrahim Abdalla Mawahib Eldigail Nuha Elagib Ulrike Arnold Bernardo Gutierrez Oliver G Pybus Daniel P Carter Steven T Pullan Shevin T Jacob Tajeldin Mohammedein Abdallah Benedict Gannon Tom E Fletcher 2021-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009387 https://doaj.org/article/cc6646bf211b4466b1167ed4beff6a79 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009387 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009387 https://doaj.org/article/cc6646bf211b4466b1167ed4beff6a79 PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009387 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009387 2022-12-31T05:55:01Z Background The public health impact of Chikungunya virus (CHIKV) is often underestimated. Usually considered a mild condition of short duration, recent outbreaks have reported greater incidence of severe illness, fatality, and longer-term disability. In 2018/19, Eastern Sudan experienced the largest epidemic of CHIKV in Africa to date, affecting an estimated 487,600 people. Known locally as Kankasha, this study examines clinical characteristics, risk factors, and phylogenetics of the epidemic in Kassala City. Methodology/principal findings A prospective cohort of 102 adults and 40 children presenting with chikungunya-like illness were enrolled at Kassala Teaching Hospital in October 2018. Clinical information, socio-demographic data, and sera samples were analysed to confirm diagnosis, characterise illness, and identify viral strain. CHIKV infection was confirmed by real-time reverse transcription-PCR in 84.5% (120/142) of participants. Nine (7.5%) CHIKV-positive participants had concurrent Dengue virus (DENV) infection; 34/118 participants (28.8%) had a positive Rapid Diagnostic Test for Plasmodium falciparum; six (5.0%) had haemorrhagic symptoms including two children with life-threatening bleeding. One CHIKV-positive participant died with acute renal injury. Age was not associated with severity of illness although CHIKV-infected participants were younger (p = 0.003). Two to four months post-illness, 63% of adults available for follow-up (30) were still experiencing arthralgia in one or more joints, and 11% remained moderately disabled on Rapid3 assessment. Phylogenetic analysis showed all CHIKV sequences from this study belonged to a single clade within the Indian Ocean Lineage (IOL) of the East/Central/South African (ECSA) genotype. History of contact with an infected person was the only factor associated with infection (p = 0.01), and likely related to being in the same vector environment. Conclusions/significance Vulnerability to CHIKV remains in Kassala and elsewhere in Sudan due to widespread Aedes ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Indian PLOS Neglected Tropical Diseases 15 4 e0009387 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Hilary Bower Mubarak El Karsany Abd Alhadi Adam Hussein Adam Mubarak Ibrahim Idriss Ma'aaza Abasher Alzain Mohamed Elamin Ahmed Alfakiyousif Rehab Mohamed Iman Mahmoud Omer Albadri Suha Abdulaziz Alnour Mahmoud Orwa Ibrahim Abdalla Mawahib Eldigail Nuha Elagib Ulrike Arnold Bernardo Gutierrez Oliver G Pybus Daniel P Carter Steven T Pullan Shevin T Jacob Tajeldin Mohammedein Abdallah Benedict Gannon Tom E Fletcher "Kankasha" in Kassala: A prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background The public health impact of Chikungunya virus (CHIKV) is often underestimated. Usually considered a mild condition of short duration, recent outbreaks have reported greater incidence of severe illness, fatality, and longer-term disability. In 2018/19, Eastern Sudan experienced the largest epidemic of CHIKV in Africa to date, affecting an estimated 487,600 people. Known locally as Kankasha, this study examines clinical characteristics, risk factors, and phylogenetics of the epidemic in Kassala City. Methodology/principal findings A prospective cohort of 102 adults and 40 children presenting with chikungunya-like illness were enrolled at Kassala Teaching Hospital in October 2018. Clinical information, socio-demographic data, and sera samples were analysed to confirm diagnosis, characterise illness, and identify viral strain. CHIKV infection was confirmed by real-time reverse transcription-PCR in 84.5% (120/142) of participants. Nine (7.5%) CHIKV-positive participants had concurrent Dengue virus (DENV) infection; 34/118 participants (28.8%) had a positive Rapid Diagnostic Test for Plasmodium falciparum; six (5.0%) had haemorrhagic symptoms including two children with life-threatening bleeding. One CHIKV-positive participant died with acute renal injury. Age was not associated with severity of illness although CHIKV-infected participants were younger (p = 0.003). Two to four months post-illness, 63% of adults available for follow-up (30) were still experiencing arthralgia in one or more joints, and 11% remained moderately disabled on Rapid3 assessment. Phylogenetic analysis showed all CHIKV sequences from this study belonged to a single clade within the Indian Ocean Lineage (IOL) of the East/Central/South African (ECSA) genotype. History of contact with an infected person was the only factor associated with infection (p = 0.01), and likely related to being in the same vector environment. Conclusions/significance Vulnerability to CHIKV remains in Kassala and elsewhere in Sudan due to widespread Aedes ... |
format |
Article in Journal/Newspaper |
author |
Hilary Bower Mubarak El Karsany Abd Alhadi Adam Hussein Adam Mubarak Ibrahim Idriss Ma'aaza Abasher Alzain Mohamed Elamin Ahmed Alfakiyousif Rehab Mohamed Iman Mahmoud Omer Albadri Suha Abdulaziz Alnour Mahmoud Orwa Ibrahim Abdalla Mawahib Eldigail Nuha Elagib Ulrike Arnold Bernardo Gutierrez Oliver G Pybus Daniel P Carter Steven T Pullan Shevin T Jacob Tajeldin Mohammedein Abdallah Benedict Gannon Tom E Fletcher |
author_facet |
Hilary Bower Mubarak El Karsany Abd Alhadi Adam Hussein Adam Mubarak Ibrahim Idriss Ma'aaza Abasher Alzain Mohamed Elamin Ahmed Alfakiyousif Rehab Mohamed Iman Mahmoud Omer Albadri Suha Abdulaziz Alnour Mahmoud Orwa Ibrahim Abdalla Mawahib Eldigail Nuha Elagib Ulrike Arnold Bernardo Gutierrez Oliver G Pybus Daniel P Carter Steven T Pullan Shevin T Jacob Tajeldin Mohammedein Abdallah Benedict Gannon Tom E Fletcher |
author_sort |
Hilary Bower |
title |
"Kankasha" in Kassala: A prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan. |
title_short |
"Kankasha" in Kassala: A prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan. |
title_full |
"Kankasha" in Kassala: A prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan. |
title_fullStr |
"Kankasha" in Kassala: A prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan. |
title_full_unstemmed |
"Kankasha" in Kassala: A prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan. |
title_sort |
"kankasha" in kassala: a prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of chikungunya virus infection in kassala, sudan. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009387 https://doaj.org/article/cc6646bf211b4466b1167ed4beff6a79 |
geographic |
Arctic Indian |
geographic_facet |
Arctic Indian |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009387 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009387 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009387 https://doaj.org/article/cc6646bf211b4466b1167ed4beff6a79 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009387 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
4 |
container_start_page |
e0009387 |
_version_ |
1766344636002992128 |