Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response
Objective: To evaluate the potential immunomodulatory effects of an aqueous extract of Sesamum indicum seeds with regard to splenocyte proliferation, Th1/Th2 balance, macrophage function, and the cytotoxic activity of natural killer (NK) cells. Methods: Splenocyte proliferation was measured by [H]-...
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Wolters Kluwer Medknow Publications
2020
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ftdoajarticles:oai:doaj.org/article:cc504efd122f40709fa29fa0c4e7c7ca 2023-05-15T15:07:22+02:00 Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response Amin F Majdalawieh Jenna F Farraj Ronald I Carr 2020-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.284946 https://doaj.org/article/cc504efd122f40709fa29fa0c4e7c7ca EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=7;spage=316;epage=324;aulast=Majdalawieh https://doaj.org/toc/2588-9222 2588-9222 doi:10.4103/2221-1691.284946 https://doaj.org/article/cc504efd122f40709fa29fa0c4e7c7ca Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 7, Pp 316-324 (2020) sesamum indicum anti-cancer inflammation immunomodulation macrophages nk cells Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2020 ftdoajarticles https://doi.org/10.4103/2221-1691.284946 2022-12-31T06:13:32Z Objective: To evaluate the potential immunomodulatory effects of an aqueous extract of Sesamum indicum seeds with regard to splenocyte proliferation, Th1/Th2 balance, macrophage function, and the cytotoxic activity of natural killer (NK) cells. Methods: Splenocyte proliferation was measured by [H]- thymidine incorporation. Griess assay was performed to evaluate the production of nitric oxide by macrophages. The levels of cytokines secreted by splenocytes and macrophages were measured by ELISA. JAM assay was performed to examine the cytotoxic activity of NK cells against YAC-1 tumor cells. Results: Sesamum indicum significantly enhanced splenocyte proliferation in a dose-dependent manner. Sesamum indicum also increased and suppressed the secretion of Th1 and Th2 cytokines, respectively, by splenocytes. The secretion of key pro-inflammatory mediators (IL-6, TNFα, and nitric oxide) by primary macrophages was significantly inhibited by Sesamum indicum. Moreover, Sesamum indicum increased the cytotoxic activity of NK cells against YAC-1 tumor cells. Conclusions: Sesamum indicum shows potent immunomodulatory, anti-inflammatory, and anti-cancer effects. Constituents of Sesamum indicum may be used as effective therapeutic agents in regulating immune reactions implicated in various infectious and non- infectious conditions including cancer. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 10 7 316 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
sesamum indicum anti-cancer inflammation immunomodulation macrophages nk cells Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
sesamum indicum anti-cancer inflammation immunomodulation macrophages nk cells Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Amin F Majdalawieh Jenna F Farraj Ronald I Carr Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response |
topic_facet |
sesamum indicum anti-cancer inflammation immunomodulation macrophages nk cells Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the potential immunomodulatory effects of an aqueous extract of Sesamum indicum seeds with regard to splenocyte proliferation, Th1/Th2 balance, macrophage function, and the cytotoxic activity of natural killer (NK) cells. Methods: Splenocyte proliferation was measured by [H]- thymidine incorporation. Griess assay was performed to evaluate the production of nitric oxide by macrophages. The levels of cytokines secreted by splenocytes and macrophages were measured by ELISA. JAM assay was performed to examine the cytotoxic activity of NK cells against YAC-1 tumor cells. Results: Sesamum indicum significantly enhanced splenocyte proliferation in a dose-dependent manner. Sesamum indicum also increased and suppressed the secretion of Th1 and Th2 cytokines, respectively, by splenocytes. The secretion of key pro-inflammatory mediators (IL-6, TNFα, and nitric oxide) by primary macrophages was significantly inhibited by Sesamum indicum. Moreover, Sesamum indicum increased the cytotoxic activity of NK cells against YAC-1 tumor cells. Conclusions: Sesamum indicum shows potent immunomodulatory, anti-inflammatory, and anti-cancer effects. Constituents of Sesamum indicum may be used as effective therapeutic agents in regulating immune reactions implicated in various infectious and non- infectious conditions including cancer. |
format |
Article in Journal/Newspaper |
author |
Amin F Majdalawieh Jenna F Farraj Ronald I Carr |
author_facet |
Amin F Majdalawieh Jenna F Farraj Ronald I Carr |
author_sort |
Amin F Majdalawieh |
title |
Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response |
title_short |
Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response |
title_full |
Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response |
title_fullStr |
Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response |
title_full_unstemmed |
Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response |
title_sort |
sesamum indicum (sesame) enhances nk anti-cancer activity, modulates th1/th2 balance, and suppresses macrophage inflammatory response |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/2221-1691.284946 https://doaj.org/article/cc504efd122f40709fa29fa0c4e7c7ca |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 7, Pp 316-324 (2020) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=7;spage=316;epage=324;aulast=Majdalawieh https://doaj.org/toc/2588-9222 2588-9222 doi:10.4103/2221-1691.284946 https://doaj.org/article/cc504efd122f40709fa29fa0c4e7c7ca |
op_doi |
https://doi.org/10.4103/2221-1691.284946 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
10 |
container_issue |
7 |
container_start_page |
316 |
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1766338886856867840 |