Arctic lineage-canine distemper virus as a cause of death in Apennine wolves (Canis lupus) in Italy.

• Published in: PLoS ONE
• Main Authors: Daria Di Sabatino, Alessio Lorusso, Cristina E Di Francesco, Leonardo Gentile, Vincenza Di Pirro, Anna Lucia Bellacicco, Armando Giovannini, Gabriella Di Francesco, Giuseppe Marruchella, Fulvio Marsilio, Giovanni Savini
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2014
• Subjects: Medicine; R; Science; Q; Arctic; Canis lupus
• Online Access: https://doi.org/10.1371/journal.pone.0082356; https://doaj.org/article/cc4bc8655c6046f682ff8d3eca16b358

Canine distemper virus (CDV) infection is a primary threat affecting a wide number of carnivore species, including wild animals. In January 2013, two carcasses of Apennine wolves (Canis lupus) were collected in Ortona dei Marsi (L'Aquila province, Italy) by the local Veterinary Services. CDV was immediately identified either by RT-PCR or immunohistochemistry in lung and central nervous tissue samples. At the same time, severe clinical signs consistent with CDV infection were identified and taped (Videos S1-S3) from three wolves rescued in the areas surrounding the National Parks of the Abruzzi region by the Veterinary Services. The samples collected from these symptomatic animals also turned out CDV positive by RT-PCR. So far, 30 carcasses of wolves were screened and CDV was detected in 20 of them. The sequencing of the haemagglutinin gene and subsequent phylogenetic analysis demonstrated that the identified virus belonged to the CDV Arctic lineage. Strains belonging to this lineage are known to circulate in Italy and in Eastern Europe amongst domestic dogs. To the best of our knowledge this is the first report of CDV Arctic lineage epidemics in the wild population in Europe.