Pharmacological characterization of rat paw edema induced by Cerastes gasperettii (cerastes) venom
Inflammatory response induced by the venom of the Arabian sand viper Cerastes gasperettii was studied by measuring rat hind-paw edema. Cerastes gasperettii venom (CgV, 3.75-240 µg/paw), heated for 30s at 97°C, caused a marked dose and time-dependent edema in rat paw. Response was maximal 2h after ve...
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ftdoajarticles:oai:doaj.org/article:cc485a63f6d24c659ca54d1f8a2420fa 2023-05-15T15:06:19+02:00 Pharmacological characterization of rat paw edema induced by Cerastes gasperettii (cerastes) venom A. K. Al-Asmari N. M. Abdo 2006-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992006000300005 https://doaj.org/article/cc485a63f6d24c659ca54d1f8a2420fa EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000300005 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000300005 1678-9199 https://doaj.org/article/cc485a63f6d24c659ca54d1f8a2420fa Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 3, Pp 400-417 (2006) inflammatory mediators Cerastes gasperettii venom edema antagonist antivenom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2006 ftdoajarticles https://doi.org/10.1590/S1678-91992006000300005 2022-12-31T06:13:11Z Inflammatory response induced by the venom of the Arabian sand viper Cerastes gasperettii was studied by measuring rat hind-paw edema. Cerastes gasperettii venom (CgV, 3.75-240 µg/paw), heated for 30s at 97°C, caused a marked dose and time-dependent edema in rat paw. Response was maximal 2h after venom administration and ceased within 24h. Heated CgV was routinely used in our experiments at the dose of 120 µg/paw. Among all the drugs and antivenoms tested, cyproheptadine and 5-nitroindazole were the most effective in inhibiting edema formation. Aprotinin, mepyramine, dexamethasone, diclofenac, dipyridamole, Nomega-nitro-L-arginine, quinacrine, and nordihydroguaiaretic acid showed statistically (p<0.001) significant inhibitory effect, but with variations in their inhibition degree. Equine polyspecific and rabbit monospecific antivenoms significantly (p<0.001) reduced edema when locally administered (subplantar) but were ineffective when intravenously injected. We can conclude that the principal inflammatory mediators were serotonin, histamine, adenosine transport factors, phosphodiesterase (PDE), cyclooxygenase, lipoxygenase and phospholipase A2 (PLA2), in addition to other prostaglandins and cytokines. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 12 3 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
inflammatory mediators Cerastes gasperettii venom edema antagonist antivenom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
inflammatory mediators Cerastes gasperettii venom edema antagonist antivenom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 A. K. Al-Asmari N. M. Abdo Pharmacological characterization of rat paw edema induced by Cerastes gasperettii (cerastes) venom |
topic_facet |
inflammatory mediators Cerastes gasperettii venom edema antagonist antivenom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Inflammatory response induced by the venom of the Arabian sand viper Cerastes gasperettii was studied by measuring rat hind-paw edema. Cerastes gasperettii venom (CgV, 3.75-240 µg/paw), heated for 30s at 97°C, caused a marked dose and time-dependent edema in rat paw. Response was maximal 2h after venom administration and ceased within 24h. Heated CgV was routinely used in our experiments at the dose of 120 µg/paw. Among all the drugs and antivenoms tested, cyproheptadine and 5-nitroindazole were the most effective in inhibiting edema formation. Aprotinin, mepyramine, dexamethasone, diclofenac, dipyridamole, Nomega-nitro-L-arginine, quinacrine, and nordihydroguaiaretic acid showed statistically (p<0.001) significant inhibitory effect, but with variations in their inhibition degree. Equine polyspecific and rabbit monospecific antivenoms significantly (p<0.001) reduced edema when locally administered (subplantar) but were ineffective when intravenously injected. We can conclude that the principal inflammatory mediators were serotonin, histamine, adenosine transport factors, phosphodiesterase (PDE), cyclooxygenase, lipoxygenase and phospholipase A2 (PLA2), in addition to other prostaglandins and cytokines. |
format |
Article in Journal/Newspaper |
author |
A. K. Al-Asmari N. M. Abdo |
author_facet |
A. K. Al-Asmari N. M. Abdo |
author_sort |
A. K. Al-Asmari |
title |
Pharmacological characterization of rat paw edema induced by Cerastes gasperettii (cerastes) venom |
title_short |
Pharmacological characterization of rat paw edema induced by Cerastes gasperettii (cerastes) venom |
title_full |
Pharmacological characterization of rat paw edema induced by Cerastes gasperettii (cerastes) venom |
title_fullStr |
Pharmacological characterization of rat paw edema induced by Cerastes gasperettii (cerastes) venom |
title_full_unstemmed |
Pharmacological characterization of rat paw edema induced by Cerastes gasperettii (cerastes) venom |
title_sort |
pharmacological characterization of rat paw edema induced by cerastes gasperettii (cerastes) venom |
publisher |
SciELO |
publishDate |
2006 |
url |
https://doi.org/10.1590/S1678-91992006000300005 https://doaj.org/article/cc485a63f6d24c659ca54d1f8a2420fa |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 3, Pp 400-417 (2006) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000300005 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000300005 1678-9199 https://doaj.org/article/cc485a63f6d24c659ca54d1f8a2420fa |
op_doi |
https://doi.org/10.1590/S1678-91992006000300005 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
12 |
container_issue |
3 |
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1766337954259664896 |