Low bone mineral density among HIV-infected patients in Brazil
ABSTRACT Decrease in bone mineral density (BMD) has been a complication among people living with HIV/AIDS. To investigate the prevalence of osteopenia/osteoporosis among HIV-infected people living in São Paulo city, we studied 108 HIV-infected patients (79 men and 29 women). We extracted data from p...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Universidade de São Paulo (USP)
2017
|
Subjects: | |
Online Access: | https://doi.org/10.1590/s1678-9946201759089 https://doaj.org/article/cc3f223bff2941e9988d99edef748856 |
id |
ftdoajarticles:oai:doaj.org/article:cc3f223bff2941e9988d99edef748856 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:cc3f223bff2941e9988d99edef748856 2024-09-09T19:26:28+00:00 Low bone mineral density among HIV-infected patients in Brazil Daniela Cardeal da Silva Chaba Lisméia R. Soares Rosa M. R. Pereira George W. Rutherford Tatiane Assone Liliam Takayama Luiz A. M. Fonseca Alberto J. S. Duarte Jorge Casseb 2017-12-01T00:00:00Z https://doi.org/10.1590/s1678-9946201759089 https://doaj.org/article/cc3f223bff2941e9988d99edef748856 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000253&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201759089 https://doaj.org/article/cc3f223bff2941e9988d99edef748856 Revista do Instituto de Medicina Tropical de São Paulo, Vol 59, Iss 0 (2017) HIV Bone mineral Osteoporosis Risk factors Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2017 ftdoajarticles https://doi.org/10.1590/s1678-9946201759089 2024-08-05T17:49:30Z ABSTRACT Decrease in bone mineral density (BMD) has been a complication among people living with HIV/AIDS. To investigate the prevalence of osteopenia/osteoporosis among HIV-infected people living in São Paulo city, we studied 108 HIV-infected patients (79 men and 29 women). We extracted data from patients’ medical records and BMD was measured by dual-energy X-ray absorptiometry (DXA). Median age of participants was 42 years (interquartile range [IQR] 36-48 years), and the median time since HIV diagnosis was 4.01 years (IQR 2-11 years). Patients had acquired HIV primarily by the sexual route (men who have sex with men 44%, heterosexual 49%). Median age, duration of HIV infection, duration of ART and CD4 nadir were similar for men and women. Plasma viral load was undetectable for 53 patients (49%). Median CD4 T cell count was 399 cells/µL (IQR 247 - 568). Twenty five patients (23%) had LBMD, and there was no statistically significant difference between men and women (<-1). The associated risk factors for LBMD were older age (≥ 50 years old) and smoking with a RR of 3.87 and 2.80, respectively. Thus, despite the lack of statistically significant relationship between the use of ART and LBMD or between duration of ART and LBMD, these factors should be addressed in larger studies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 59 0 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
HIV Bone mineral Osteoporosis Risk factors Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
HIV Bone mineral Osteoporosis Risk factors Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Daniela Cardeal da Silva Chaba Lisméia R. Soares Rosa M. R. Pereira George W. Rutherford Tatiane Assone Liliam Takayama Luiz A. M. Fonseca Alberto J. S. Duarte Jorge Casseb Low bone mineral density among HIV-infected patients in Brazil |
topic_facet |
HIV Bone mineral Osteoporosis Risk factors Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
ABSTRACT Decrease in bone mineral density (BMD) has been a complication among people living with HIV/AIDS. To investigate the prevalence of osteopenia/osteoporosis among HIV-infected people living in São Paulo city, we studied 108 HIV-infected patients (79 men and 29 women). We extracted data from patients’ medical records and BMD was measured by dual-energy X-ray absorptiometry (DXA). Median age of participants was 42 years (interquartile range [IQR] 36-48 years), and the median time since HIV diagnosis was 4.01 years (IQR 2-11 years). Patients had acquired HIV primarily by the sexual route (men who have sex with men 44%, heterosexual 49%). Median age, duration of HIV infection, duration of ART and CD4 nadir were similar for men and women. Plasma viral load was undetectable for 53 patients (49%). Median CD4 T cell count was 399 cells/µL (IQR 247 - 568). Twenty five patients (23%) had LBMD, and there was no statistically significant difference between men and women (<-1). The associated risk factors for LBMD were older age (≥ 50 years old) and smoking with a RR of 3.87 and 2.80, respectively. Thus, despite the lack of statistically significant relationship between the use of ART and LBMD or between duration of ART and LBMD, these factors should be addressed in larger studies. |
format |
Article in Journal/Newspaper |
author |
Daniela Cardeal da Silva Chaba Lisméia R. Soares Rosa M. R. Pereira George W. Rutherford Tatiane Assone Liliam Takayama Luiz A. M. Fonseca Alberto J. S. Duarte Jorge Casseb |
author_facet |
Daniela Cardeal da Silva Chaba Lisméia R. Soares Rosa M. R. Pereira George W. Rutherford Tatiane Assone Liliam Takayama Luiz A. M. Fonseca Alberto J. S. Duarte Jorge Casseb |
author_sort |
Daniela Cardeal da Silva Chaba |
title |
Low bone mineral density among HIV-infected patients in Brazil |
title_short |
Low bone mineral density among HIV-infected patients in Brazil |
title_full |
Low bone mineral density among HIV-infected patients in Brazil |
title_fullStr |
Low bone mineral density among HIV-infected patients in Brazil |
title_full_unstemmed |
Low bone mineral density among HIV-infected patients in Brazil |
title_sort |
low bone mineral density among hiv-infected patients in brazil |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2017 |
url |
https://doi.org/10.1590/s1678-9946201759089 https://doaj.org/article/cc3f223bff2941e9988d99edef748856 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 59, Iss 0 (2017) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000253&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201759089 https://doaj.org/article/cc3f223bff2941e9988d99edef748856 |
op_doi |
https://doi.org/10.1590/s1678-9946201759089 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
59 |
container_issue |
0 |
_version_ |
1809896068083613696 |