Oyster extracts attenuate pathological changes in non-alcoholic steatohepatitis (NASH) mouse model

• Published in: Journal of Functional Foods
• Main Authors: Mitsugu Watanabe, Hirotoshi Fuda, Hiroaki Okabe, Sae Joko, Yusuke Miura, Shu-Ping Hui, Yimin, Naohiro Hamaoka, Emiko Miki, Hitoshi Chiba
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2016
• Subjects: Pacific oyster; Obesity; Insulin resistance; Polyphenol; Antioxidant; Nutrition. Foods and food supply; TX341-641; Nash; Pacific
• Online Access: https://doi.org/10.1016/j.jff.2015.11.029; https://doaj.org/article/cc0c8cb34c44496cbb1aed1508167e32

The phenolic compound 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA) is a natural antioxidant recently isolated from the Pacific oyster. DHMBA, up to a concentration of 500 µM, has demonstrated a strong in vitro hepatocyte-protective effect from oxidative stress without any cytotoxicity. This study i...