Oyster extracts attenuate pathological changes in non-alcoholic steatohepatitis (NASH) mouse model
The phenolic compound 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA) is a natural antioxidant recently isolated from the Pacific oyster. DHMBA, up to a concentration of 500 µM, has demonstrated a strong in vitro hepatocyte-protective effect from oxidative stress without any cytotoxicity. This study i...
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ftdoajarticles:oai:doaj.org/article:cc0c8cb34c44496cbb1aed1508167e32 2023-05-15T17:54:17+02:00 Oyster extracts attenuate pathological changes in non-alcoholic steatohepatitis (NASH) mouse model Mitsugu Watanabe Hirotoshi Fuda Hiroaki Okabe Sae Joko Yusuke Miura Shu-Ping Hui Yimin Naohiro Hamaoka Emiko Miki Hitoshi Chiba 2016-01-01T00:00:00Z https://doi.org/10.1016/j.jff.2015.11.029 https://doaj.org/article/cc0c8cb34c44496cbb1aed1508167e32 EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S1756464615005769 https://doaj.org/toc/1756-4646 1756-4646 doi:10.1016/j.jff.2015.11.029 https://doaj.org/article/cc0c8cb34c44496cbb1aed1508167e32 Journal of Functional Foods, Vol 20, Iss , Pp 516-531 (2016) Pacific oyster Obesity Insulin resistance Polyphenol Antioxidant Nutrition. Foods and food supply TX341-641 article 2016 ftdoajarticles https://doi.org/10.1016/j.jff.2015.11.029 2022-12-31T06:54:21Z The phenolic compound 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA) is a natural antioxidant recently isolated from the Pacific oyster. DHMBA, up to a concentration of 500 µM, has demonstrated a strong in vitro hepatocyte-protective effect from oxidative stress without any cytotoxicity. This study investigated the in vivo potential of DHMBA-rich oyster extracts (DOE) for prevention or attenuation of non-alcoholic steatohepatitis (NASH). NASH-model mice, developed by supplementation of a high-fat diet for 23 weeks and intravenous injections of oxidised low-density lipoproteins, exhibited obesity, insulin resistance, hepatic steatosis, inflammation, fibrosis, and apoptosis. These changes were significantly moderated by supplementation of DOE. The search for an underlying mechanism determined that DOE significantly improved the redox status of DNA, proteins, and lipids. Moreover, DOE suppressed the increase of hepatic expression of PPARγ and CD36 (fatty acid transporter) in the NASH-model mice. DOE might serve as a functional food for people at elevated risk for NASH. Article in Journal/Newspaper Pacific oyster Directory of Open Access Journals: DOAJ Articles Nash ENVELOPE(-62.350,-62.350,-74.233,-74.233) Pacific Journal of Functional Foods 20 516 531 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Pacific oyster Obesity Insulin resistance Polyphenol Antioxidant Nutrition. Foods and food supply TX341-641 |
spellingShingle |
Pacific oyster Obesity Insulin resistance Polyphenol Antioxidant Nutrition. Foods and food supply TX341-641 Mitsugu Watanabe Hirotoshi Fuda Hiroaki Okabe Sae Joko Yusuke Miura Shu-Ping Hui Yimin Naohiro Hamaoka Emiko Miki Hitoshi Chiba Oyster extracts attenuate pathological changes in non-alcoholic steatohepatitis (NASH) mouse model |
topic_facet |
Pacific oyster Obesity Insulin resistance Polyphenol Antioxidant Nutrition. Foods and food supply TX341-641 |
description |
The phenolic compound 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA) is a natural antioxidant recently isolated from the Pacific oyster. DHMBA, up to a concentration of 500 µM, has demonstrated a strong in vitro hepatocyte-protective effect from oxidative stress without any cytotoxicity. This study investigated the in vivo potential of DHMBA-rich oyster extracts (DOE) for prevention or attenuation of non-alcoholic steatohepatitis (NASH). NASH-model mice, developed by supplementation of a high-fat diet for 23 weeks and intravenous injections of oxidised low-density lipoproteins, exhibited obesity, insulin resistance, hepatic steatosis, inflammation, fibrosis, and apoptosis. These changes were significantly moderated by supplementation of DOE. The search for an underlying mechanism determined that DOE significantly improved the redox status of DNA, proteins, and lipids. Moreover, DOE suppressed the increase of hepatic expression of PPARγ and CD36 (fatty acid transporter) in the NASH-model mice. DOE might serve as a functional food for people at elevated risk for NASH. |
format |
Article in Journal/Newspaper |
author |
Mitsugu Watanabe Hirotoshi Fuda Hiroaki Okabe Sae Joko Yusuke Miura Shu-Ping Hui Yimin Naohiro Hamaoka Emiko Miki Hitoshi Chiba |
author_facet |
Mitsugu Watanabe Hirotoshi Fuda Hiroaki Okabe Sae Joko Yusuke Miura Shu-Ping Hui Yimin Naohiro Hamaoka Emiko Miki Hitoshi Chiba |
author_sort |
Mitsugu Watanabe |
title |
Oyster extracts attenuate pathological changes in non-alcoholic steatohepatitis (NASH) mouse model |
title_short |
Oyster extracts attenuate pathological changes in non-alcoholic steatohepatitis (NASH) mouse model |
title_full |
Oyster extracts attenuate pathological changes in non-alcoholic steatohepatitis (NASH) mouse model |
title_fullStr |
Oyster extracts attenuate pathological changes in non-alcoholic steatohepatitis (NASH) mouse model |
title_full_unstemmed |
Oyster extracts attenuate pathological changes in non-alcoholic steatohepatitis (NASH) mouse model |
title_sort |
oyster extracts attenuate pathological changes in non-alcoholic steatohepatitis (nash) mouse model |
publisher |
Elsevier |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.jff.2015.11.029 https://doaj.org/article/cc0c8cb34c44496cbb1aed1508167e32 |
long_lat |
ENVELOPE(-62.350,-62.350,-74.233,-74.233) |
geographic |
Nash Pacific |
geographic_facet |
Nash Pacific |
genre |
Pacific oyster |
genre_facet |
Pacific oyster |
op_source |
Journal of Functional Foods, Vol 20, Iss , Pp 516-531 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S1756464615005769 https://doaj.org/toc/1756-4646 1756-4646 doi:10.1016/j.jff.2015.11.029 https://doaj.org/article/cc0c8cb34c44496cbb1aed1508167e32 |
op_doi |
https://doi.org/10.1016/j.jff.2015.11.029 |
container_title |
Journal of Functional Foods |
container_volume |
20 |
container_start_page |
516 |
op_container_end_page |
531 |
_version_ |
1766162023602716672 |