Per- and Polyfluoroalkyl Substances (PFAS) Neurotoxicity in Sentinel and Non-Traditional Laboratory Model Systems: Potential Utility in Predicting Adverse Outcomes in Human Health
Per- and polyfluoroalkyl substances (PFAS) are a class of chemicals that were widely used in manufacturing and are now present in the environment throughout the world. It is known that various PFAS are quantifiable in human in blood, but potential adverse health outcomes remain unclear. Sentinel and...
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ftdoajarticles:oai:doaj.org/article:cbf11573c2774e6c927b738d41c7d49a 2023-05-15T18:42:26+02:00 Per- and Polyfluoroalkyl Substances (PFAS) Neurotoxicity in Sentinel and Non-Traditional Laboratory Model Systems: Potential Utility in Predicting Adverse Outcomes in Human Health Rachel Foguth Maria S. Sepúlveda Jason Cannon 2020-06-01T00:00:00Z https://doi.org/10.3390/toxics8020042 https://doaj.org/article/cbf11573c2774e6c927b738d41c7d49a EN eng MDPI AG https://www.mdpi.com/2305-6304/8/2/42 https://doaj.org/toc/2305-6304 doi:10.3390/toxics8020042 2305-6304 https://doaj.org/article/cbf11573c2774e6c927b738d41c7d49a Toxics, Vol 8, Iss 42, p 42 (2020) per- and polyfluoroalkyl substances sentinel species perfluorooctane sulfonate perfluorooctanoate perfluorobutane sulfonate Chemical technology TP1-1185 article 2020 ftdoajarticles https://doi.org/10.3390/toxics8020042 2022-12-30T23:41:59Z Per- and polyfluoroalkyl substances (PFAS) are a class of chemicals that were widely used in manufacturing and are now present in the environment throughout the world. It is known that various PFAS are quantifiable in human in blood, but potential adverse health outcomes remain unclear. Sentinel and non-traditional model species are useful to study potential toxicity of PFAS in order to understand the relationship between environmental and human health. Here, we present a critical review of studies on the neurotoxicity of PFAS in sentinel and non-traditional laboratory model systems, including Caenorhabditis elegans (nematode), Dugesia japonica (planarian), Rana pipiens (frogs), Danio rerio and Oryzias melastigma (fish), and Ursus maritimus (polar bears). PFAS have been implicated in developmental neurotoxicity in non-traditional and traditional model systems as well as sentinel species, including effects on neurotransmitter levels, especially acetylcholine and its metabolism. However, further research on the mechanisms of toxicity needs to be conducted to determine if these chemicals are affecting organisms in a similar manner. Overall, findings tend to be similar among the various species, but bioaccumulation may vary, which needs to be taken into account in future studies by quantifying target organ concentrations of PFAS to better compare different species. Furthermore, data on the majority of PFAS is lacking in neurotoxicity testing, and additional studies are needed to corroborate findings thus far. Article in Journal/Newspaper Ursus maritimus Directory of Open Access Journals: DOAJ Articles Toxics 8 2 42 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
per- and polyfluoroalkyl substances sentinel species perfluorooctane sulfonate perfluorooctanoate perfluorobutane sulfonate Chemical technology TP1-1185 |
spellingShingle |
per- and polyfluoroalkyl substances sentinel species perfluorooctane sulfonate perfluorooctanoate perfluorobutane sulfonate Chemical technology TP1-1185 Rachel Foguth Maria S. Sepúlveda Jason Cannon Per- and Polyfluoroalkyl Substances (PFAS) Neurotoxicity in Sentinel and Non-Traditional Laboratory Model Systems: Potential Utility in Predicting Adverse Outcomes in Human Health |
topic_facet |
per- and polyfluoroalkyl substances sentinel species perfluorooctane sulfonate perfluorooctanoate perfluorobutane sulfonate Chemical technology TP1-1185 |
description |
Per- and polyfluoroalkyl substances (PFAS) are a class of chemicals that were widely used in manufacturing and are now present in the environment throughout the world. It is known that various PFAS are quantifiable in human in blood, but potential adverse health outcomes remain unclear. Sentinel and non-traditional model species are useful to study potential toxicity of PFAS in order to understand the relationship between environmental and human health. Here, we present a critical review of studies on the neurotoxicity of PFAS in sentinel and non-traditional laboratory model systems, including Caenorhabditis elegans (nematode), Dugesia japonica (planarian), Rana pipiens (frogs), Danio rerio and Oryzias melastigma (fish), and Ursus maritimus (polar bears). PFAS have been implicated in developmental neurotoxicity in non-traditional and traditional model systems as well as sentinel species, including effects on neurotransmitter levels, especially acetylcholine and its metabolism. However, further research on the mechanisms of toxicity needs to be conducted to determine if these chemicals are affecting organisms in a similar manner. Overall, findings tend to be similar among the various species, but bioaccumulation may vary, which needs to be taken into account in future studies by quantifying target organ concentrations of PFAS to better compare different species. Furthermore, data on the majority of PFAS is lacking in neurotoxicity testing, and additional studies are needed to corroborate findings thus far. |
format |
Article in Journal/Newspaper |
author |
Rachel Foguth Maria S. Sepúlveda Jason Cannon |
author_facet |
Rachel Foguth Maria S. Sepúlveda Jason Cannon |
author_sort |
Rachel Foguth |
title |
Per- and Polyfluoroalkyl Substances (PFAS) Neurotoxicity in Sentinel and Non-Traditional Laboratory Model Systems: Potential Utility in Predicting Adverse Outcomes in Human Health |
title_short |
Per- and Polyfluoroalkyl Substances (PFAS) Neurotoxicity in Sentinel and Non-Traditional Laboratory Model Systems: Potential Utility in Predicting Adverse Outcomes in Human Health |
title_full |
Per- and Polyfluoroalkyl Substances (PFAS) Neurotoxicity in Sentinel and Non-Traditional Laboratory Model Systems: Potential Utility in Predicting Adverse Outcomes in Human Health |
title_fullStr |
Per- and Polyfluoroalkyl Substances (PFAS) Neurotoxicity in Sentinel and Non-Traditional Laboratory Model Systems: Potential Utility in Predicting Adverse Outcomes in Human Health |
title_full_unstemmed |
Per- and Polyfluoroalkyl Substances (PFAS) Neurotoxicity in Sentinel and Non-Traditional Laboratory Model Systems: Potential Utility in Predicting Adverse Outcomes in Human Health |
title_sort |
per- and polyfluoroalkyl substances (pfas) neurotoxicity in sentinel and non-traditional laboratory model systems: potential utility in predicting adverse outcomes in human health |
publisher |
MDPI AG |
publishDate |
2020 |
url |
https://doi.org/10.3390/toxics8020042 https://doaj.org/article/cbf11573c2774e6c927b738d41c7d49a |
genre |
Ursus maritimus |
genre_facet |
Ursus maritimus |
op_source |
Toxics, Vol 8, Iss 42, p 42 (2020) |
op_relation |
https://www.mdpi.com/2305-6304/8/2/42 https://doaj.org/toc/2305-6304 doi:10.3390/toxics8020042 2305-6304 https://doaj.org/article/cbf11573c2774e6c927b738d41c7d49a |
op_doi |
https://doi.org/10.3390/toxics8020042 |
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Toxics |
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8 |
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2 |
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42 |
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