Rapid diversification of FoxP2 in teleosts through gene duplication in the teleost-specific whole genome duplication event.
As one of the most conserved genes in vertebrates, FoxP2 is widely involved in a number of important physiological and developmental processes. We systematically studied the evolutionary history and functional adaptations of FoxP2 in teleosts. The duplicated FoxP2 genes (FoxP2a and FoxP2b), which we...
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ftdoajarticles:oai:doaj.org/article:cbc090b853754609a146f52dd31528dd 2023-05-15T18:09:58+02:00 Rapid diversification of FoxP2 in teleosts through gene duplication in the teleost-specific whole genome duplication event. Xiaowei Song Yajun Wang Yezhong Tang 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0083858 https://doaj.org/article/cbc090b853754609a146f52dd31528dd EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3857310?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0083858 https://doaj.org/article/cbc090b853754609a146f52dd31528dd PLoS ONE, Vol 8, Iss 12, p e83858 (2013) Medicine R Science Q article 2013 ftdoajarticles https://doi.org/10.1371/journal.pone.0083858 2022-12-31T10:41:13Z As one of the most conserved genes in vertebrates, FoxP2 is widely involved in a number of important physiological and developmental processes. We systematically studied the evolutionary history and functional adaptations of FoxP2 in teleosts. The duplicated FoxP2 genes (FoxP2a and FoxP2b), which were identified in teleosts using synteny and paralogon analysis on genome databases of eight organisms, were probably generated in the teleost-specific whole genome duplication event. A credible classification with FoxP2, FoxP2a and FoxP2b in phylogenetic reconstructions confirmed the teleost-specific FoxP2 duplication. The unavailability of FoxP2b in Danio rerio suggests that the gene was deleted through nonfunctionalization of the redundant copy after the Otocephala-Euteleostei split. Heterogeneity in evolutionary rates among clusters consisting of FoxP2 in Sarcopterygii (Cluster 1), FoxP2a in Teleostei (Cluster 2) and FoxP2b in Teleostei (Cluster 3), particularly between Clusters 2 and 3, reveals asymmetric functional divergence after the gene duplication. Hierarchical cluster analyses of hydrophobicity profiles demonstrated significant structural divergence among the three clusters with verification of subsequent stepwise discriminant analysis, in which FoxP2 of Leucoraja erinacea and Lepisosteus oculatus were classified into Cluster 1, whereas FoxP2b of Salmo salar was grouped into Cluster 2 rather than Cluster 3. The simulated thermodynamic stability variations of the forkhead box domain (monomer and homodimer) showed remarkable divergence in FoxP2, FoxP2a and FoxP2b clusters. Relaxed purifying selection and positive Darwinian selection probably were complementary driving forces for the accelerated evolution of FoxP2 in ray-finned fishes, especially for the adaptive evolution of FoxP2a and FoxP2b in teleosts subsequent to the teleost-specific gene duplication. Article in Journal/Newspaper Salmo salar Directory of Open Access Journals: DOAJ Articles PLoS ONE 8 12 e83858 |
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Medicine R Science Q Xiaowei Song Yajun Wang Yezhong Tang Rapid diversification of FoxP2 in teleosts through gene duplication in the teleost-specific whole genome duplication event. |
topic_facet |
Medicine R Science Q |
description |
As one of the most conserved genes in vertebrates, FoxP2 is widely involved in a number of important physiological and developmental processes. We systematically studied the evolutionary history and functional adaptations of FoxP2 in teleosts. The duplicated FoxP2 genes (FoxP2a and FoxP2b), which were identified in teleosts using synteny and paralogon analysis on genome databases of eight organisms, were probably generated in the teleost-specific whole genome duplication event. A credible classification with FoxP2, FoxP2a and FoxP2b in phylogenetic reconstructions confirmed the teleost-specific FoxP2 duplication. The unavailability of FoxP2b in Danio rerio suggests that the gene was deleted through nonfunctionalization of the redundant copy after the Otocephala-Euteleostei split. Heterogeneity in evolutionary rates among clusters consisting of FoxP2 in Sarcopterygii (Cluster 1), FoxP2a in Teleostei (Cluster 2) and FoxP2b in Teleostei (Cluster 3), particularly between Clusters 2 and 3, reveals asymmetric functional divergence after the gene duplication. Hierarchical cluster analyses of hydrophobicity profiles demonstrated significant structural divergence among the three clusters with verification of subsequent stepwise discriminant analysis, in which FoxP2 of Leucoraja erinacea and Lepisosteus oculatus were classified into Cluster 1, whereas FoxP2b of Salmo salar was grouped into Cluster 2 rather than Cluster 3. The simulated thermodynamic stability variations of the forkhead box domain (monomer and homodimer) showed remarkable divergence in FoxP2, FoxP2a and FoxP2b clusters. Relaxed purifying selection and positive Darwinian selection probably were complementary driving forces for the accelerated evolution of FoxP2 in ray-finned fishes, especially for the adaptive evolution of FoxP2a and FoxP2b in teleosts subsequent to the teleost-specific gene duplication. |
format |
Article in Journal/Newspaper |
author |
Xiaowei Song Yajun Wang Yezhong Tang |
author_facet |
Xiaowei Song Yajun Wang Yezhong Tang |
author_sort |
Xiaowei Song |
title |
Rapid diversification of FoxP2 in teleosts through gene duplication in the teleost-specific whole genome duplication event. |
title_short |
Rapid diversification of FoxP2 in teleosts through gene duplication in the teleost-specific whole genome duplication event. |
title_full |
Rapid diversification of FoxP2 in teleosts through gene duplication in the teleost-specific whole genome duplication event. |
title_fullStr |
Rapid diversification of FoxP2 in teleosts through gene duplication in the teleost-specific whole genome duplication event. |
title_full_unstemmed |
Rapid diversification of FoxP2 in teleosts through gene duplication in the teleost-specific whole genome duplication event. |
title_sort |
rapid diversification of foxp2 in teleosts through gene duplication in the teleost-specific whole genome duplication event. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pone.0083858 https://doaj.org/article/cbc090b853754609a146f52dd31528dd |
genre |
Salmo salar |
genre_facet |
Salmo salar |
op_source |
PLoS ONE, Vol 8, Iss 12, p e83858 (2013) |
op_relation |
http://europepmc.org/articles/PMC3857310?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0083858 https://doaj.org/article/cbc090b853754609a146f52dd31528dd |
op_doi |
https://doi.org/10.1371/journal.pone.0083858 |
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PLoS ONE |
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8 |
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12 |
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e83858 |
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