Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children
Abstract Background Intermittent preventive treatment in children (IPTc) is a promising strategy to control malaria morbidity. A significant concern is whether IPTc increases children's susceptibility to subsequent malaria infection by altering their anti- Plasmodium acquired immunity. Methods...
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ftdoajarticles:oai:doaj.org/article:cb7e540cd40a46b4a6a5bc3fbc8c6516 2023-05-15T15:07:03+02:00 Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children Riveau Gilles Trape Jean-François Schacht Anne-Marie Cisse Badara Sokhna Cheikh Fillol Florie Sarr Jean Boulanger Denis Simondon François Greenwood Brian Remoué Franck 2010-12-01T00:00:00Z https://doi.org/10.1186/1475-2875-9-363 https://doaj.org/article/cb7e540cd40a46b4a6a5bc3fbc8c6516 EN eng BMC http://www.malariajournal.com/content/9/1/363 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-363 1475-2875 https://doaj.org/article/cb7e540cd40a46b4a6a5bc3fbc8c6516 Malaria Journal, Vol 9, Iss 1, p 363 (2010) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2010 ftdoajarticles https://doi.org/10.1186/1475-2875-9-363 2022-12-31T05:50:36Z Abstract Background Intermittent preventive treatment in children (IPTc) is a promising strategy to control malaria morbidity. A significant concern is whether IPTc increases children's susceptibility to subsequent malaria infection by altering their anti- Plasmodium acquired immunity. Methods To investigate this concern, IgG antibody (Ab) responses to Plasmodium falciparum schizont extract were measured in Senegalese children (6 months-5 years old) who had received three rounds of IPTc with artesunate + sulphadoxine-pyrimethamine (or placebo) at monthly intervals eight months earlier. Potential confounding factors, such as asexual malaria parasitaemia and nutritional status were also evaluated. Results Firstly, a bivariate analysis showed that children who had received IPTc had lower anti- Plasmodium IgG Ab levels than the non-treated controls. When epidemiological parameters were incorporated into a multivariate regression, gender, nutritional status and haemoglobin concentration did not have any significant influence. In contrast, parasitaemia, past malaria morbidity and increasing age were strongly associated with a higher specific IgG response. Conclusions The intensity of the contacts with P. falciparum seems to represent the main factor influencing anti-schizont IgG responses. Previous IPTc does not seem to interfere with this parasite-dependent acquired humoral response eight months after the last drug administration. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 9 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Riveau Gilles Trape Jean-François Schacht Anne-Marie Cisse Badara Sokhna Cheikh Fillol Florie Sarr Jean Boulanger Denis Simondon François Greenwood Brian Remoué Franck Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Intermittent preventive treatment in children (IPTc) is a promising strategy to control malaria morbidity. A significant concern is whether IPTc increases children's susceptibility to subsequent malaria infection by altering their anti- Plasmodium acquired immunity. Methods To investigate this concern, IgG antibody (Ab) responses to Plasmodium falciparum schizont extract were measured in Senegalese children (6 months-5 years old) who had received three rounds of IPTc with artesunate + sulphadoxine-pyrimethamine (or placebo) at monthly intervals eight months earlier. Potential confounding factors, such as asexual malaria parasitaemia and nutritional status were also evaluated. Results Firstly, a bivariate analysis showed that children who had received IPTc had lower anti- Plasmodium IgG Ab levels than the non-treated controls. When epidemiological parameters were incorporated into a multivariate regression, gender, nutritional status and haemoglobin concentration did not have any significant influence. In contrast, parasitaemia, past malaria morbidity and increasing age were strongly associated with a higher specific IgG response. Conclusions The intensity of the contacts with P. falciparum seems to represent the main factor influencing anti-schizont IgG responses. Previous IPTc does not seem to interfere with this parasite-dependent acquired humoral response eight months after the last drug administration. |
format |
Article in Journal/Newspaper |
author |
Riveau Gilles Trape Jean-François Schacht Anne-Marie Cisse Badara Sokhna Cheikh Fillol Florie Sarr Jean Boulanger Denis Simondon François Greenwood Brian Remoué Franck |
author_facet |
Riveau Gilles Trape Jean-François Schacht Anne-Marie Cisse Badara Sokhna Cheikh Fillol Florie Sarr Jean Boulanger Denis Simondon François Greenwood Brian Remoué Franck |
author_sort |
Riveau Gilles |
title |
Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children |
title_short |
Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children |
title_full |
Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children |
title_fullStr |
Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children |
title_full_unstemmed |
Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children |
title_sort |
immunological consequences of intermittent preventive treatment against malaria in senegalese preschool children |
publisher |
BMC |
publishDate |
2010 |
url |
https://doi.org/10.1186/1475-2875-9-363 https://doaj.org/article/cb7e540cd40a46b4a6a5bc3fbc8c6516 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 9, Iss 1, p 363 (2010) |
op_relation |
http://www.malariajournal.com/content/9/1/363 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-363 1475-2875 https://doaj.org/article/cb7e540cd40a46b4a6a5bc3fbc8c6516 |
op_doi |
https://doi.org/10.1186/1475-2875-9-363 |
container_title |
Malaria Journal |
container_volume |
9 |
container_issue |
1 |
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1766338624853377024 |