Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients
Abstract Background There is evidence that brain-derived neurotropic factor (BDNF) plays a protective role in the brain. Peripheral levels of BDNF correlate with its concentration in the brain. Previous studies have revealed lower serum BDNF levels in patients with mental illnesses. In most studies...
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ftdoajarticles:oai:doaj.org/article:cb19fd9a1254490b8623efb8afb75a5a 2023-05-15T17:24:42+02:00 Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients Hedda Soloey-Nilsen Kristin Nygaard-Odeh Magnhild Gangsoey Kristiansen Ole Lars Brekke Tom Eirik Mollnes Solveig Klaebo Reitan Terje Oiesvold 2022-02-01T00:00:00Z https://doi.org/10.1186/s12888-022-03744-2 https://doaj.org/article/cb19fd9a1254490b8623efb8afb75a5a EN eng BMC https://doi.org/10.1186/s12888-022-03744-2 https://doaj.org/toc/1471-244X doi:10.1186/s12888-022-03744-2 1471-244X https://doaj.org/article/cb19fd9a1254490b8623efb8afb75a5a BMC Psychiatry, Vol 22, Iss 1, Pp 1-7 (2022) Brain derived neurotropic factor (BDNF) high-sensitive- C-reactive protein (hs-CRP) general psychiatric symptoms Psychiatry RC435-571 article 2022 ftdoajarticles https://doi.org/10.1186/s12888-022-03744-2 2022-12-31T00:55:52Z Abstract Background There is evidence that brain-derived neurotropic factor (BDNF) plays a protective role in the brain. Peripheral levels of BDNF correlate with its concentration in the brain. Previous studies have revealed lower serum BDNF levels in patients with mental illnesses. In most studies serum BDNF correlates negatively with psychiatric disorders and disease severity. Most studies in this field are on psychiatric diagnosis and personality traits. The aim of our study is to explore associations between general psychiatric symptoms, independent of diagnostic groups, and serum BDNF as well as the inflammatory biomarker high-sensitive CRP (hs-CRP). Comparison between the group regularly using psychotropic medication and those not using psychotropic medication is conducted. Methods The study is a cross sectional study with 132 participants from a general open inpatient psychiatric ward at the Nordland Hospital Trust, Bodoe, Norway. Participants were assessed on serum levels of BDNF and hs-CRP. Psychiatric symptoms were assessed by a self-rating scale (Symptom check list, SCL-90- R). Multiple linear regression model was used for statistical analyses of associations between levels of BDNF, hs-CRP and symptoms. Results We found a positive association (p < 0.05), for most SCL-90 symptom clusters with BDNF in the psychotropic medication-free group. No associations were found in the group of patients using psychotropic medication, except one, the paranoid ideation cluster (p 0.022). No associations were found between hs-CRP and symptom clusters. Conclusion We found no relation between symptom clusters and the inflammatory biomarker hs-CRP. Serum BDNF levels were positively associated with intensity of psychiatric symptoms in the group of patients not using psychotropic medication. Our findings are in conflict with several previous studies reporting increased hs-CRP as well as decreased rather than increased BDNF in mental suffering. Patients on psychotropic medication may not require the same upregulation ... Article in Journal/Newspaper Nordland Nordland Nordland Directory of Open Access Journals: DOAJ Articles Norway BMC Psychiatry 22 1 |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
topic |
Brain derived neurotropic factor (BDNF) high-sensitive- C-reactive protein (hs-CRP) general psychiatric symptoms Psychiatry RC435-571 |
spellingShingle |
Brain derived neurotropic factor (BDNF) high-sensitive- C-reactive protein (hs-CRP) general psychiatric symptoms Psychiatry RC435-571 Hedda Soloey-Nilsen Kristin Nygaard-Odeh Magnhild Gangsoey Kristiansen Ole Lars Brekke Tom Eirik Mollnes Solveig Klaebo Reitan Terje Oiesvold Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
topic_facet |
Brain derived neurotropic factor (BDNF) high-sensitive- C-reactive protein (hs-CRP) general psychiatric symptoms Psychiatry RC435-571 |
description |
Abstract Background There is evidence that brain-derived neurotropic factor (BDNF) plays a protective role in the brain. Peripheral levels of BDNF correlate with its concentration in the brain. Previous studies have revealed lower serum BDNF levels in patients with mental illnesses. In most studies serum BDNF correlates negatively with psychiatric disorders and disease severity. Most studies in this field are on psychiatric diagnosis and personality traits. The aim of our study is to explore associations between general psychiatric symptoms, independent of diagnostic groups, and serum BDNF as well as the inflammatory biomarker high-sensitive CRP (hs-CRP). Comparison between the group regularly using psychotropic medication and those not using psychotropic medication is conducted. Methods The study is a cross sectional study with 132 participants from a general open inpatient psychiatric ward at the Nordland Hospital Trust, Bodoe, Norway. Participants were assessed on serum levels of BDNF and hs-CRP. Psychiatric symptoms were assessed by a self-rating scale (Symptom check list, SCL-90- R). Multiple linear regression model was used for statistical analyses of associations between levels of BDNF, hs-CRP and symptoms. Results We found a positive association (p < 0.05), for most SCL-90 symptom clusters with BDNF in the psychotropic medication-free group. No associations were found in the group of patients using psychotropic medication, except one, the paranoid ideation cluster (p 0.022). No associations were found between hs-CRP and symptom clusters. Conclusion We found no relation between symptom clusters and the inflammatory biomarker hs-CRP. Serum BDNF levels were positively associated with intensity of psychiatric symptoms in the group of patients not using psychotropic medication. Our findings are in conflict with several previous studies reporting increased hs-CRP as well as decreased rather than increased BDNF in mental suffering. Patients on psychotropic medication may not require the same upregulation ... |
format |
Article in Journal/Newspaper |
author |
Hedda Soloey-Nilsen Kristin Nygaard-Odeh Magnhild Gangsoey Kristiansen Ole Lars Brekke Tom Eirik Mollnes Solveig Klaebo Reitan Terje Oiesvold |
author_facet |
Hedda Soloey-Nilsen Kristin Nygaard-Odeh Magnhild Gangsoey Kristiansen Ole Lars Brekke Tom Eirik Mollnes Solveig Klaebo Reitan Terje Oiesvold |
author_sort |
Hedda Soloey-Nilsen |
title |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_short |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_full |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_fullStr |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_full_unstemmed |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_sort |
association between brain-derived neurotropic factor (bdnf), high-sensitivity c-reactive protein (hs-crp) and psychiatric symptoms in medicated and unmedicated patients |
publisher |
BMC |
publishDate |
2022 |
url |
https://doi.org/10.1186/s12888-022-03744-2 https://doaj.org/article/cb19fd9a1254490b8623efb8afb75a5a |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Nordland Nordland Nordland |
genre_facet |
Nordland Nordland Nordland |
op_source |
BMC Psychiatry, Vol 22, Iss 1, Pp 1-7 (2022) |
op_relation |
https://doi.org/10.1186/s12888-022-03744-2 https://doaj.org/toc/1471-244X doi:10.1186/s12888-022-03744-2 1471-244X https://doaj.org/article/cb19fd9a1254490b8623efb8afb75a5a |
op_doi |
https://doi.org/10.1186/s12888-022-03744-2 |
container_title |
BMC Psychiatry |
container_volume |
22 |
container_issue |
1 |
_version_ |
1766115813463425024 |