Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening.

• Published in: PLoS Neglected Tropical Diseases
• Main Authors: Esther Bettiol, Marie Samanovic, Andrew S Murkin, Jayne Raper, Frederick Buckner, Ana Rodriguez
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2009
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; The ''Y''
• Online Access: https://doi.org/10.1371/journal.pntd.0000384; https://doaj.org/article/caa3f56a0453461daa6b1298a3f4130c

The development of new drugs against Chagas disease is a priority since the currently available medicines have toxic effects, partial efficacy and are targeted against the acute phase of disease. At present, there is no drug to treat the chronic stage. In this study, we have optimized a whole cell-b...