NEPHROTOXICITY ATTRIBUTED TO MEGLUMINE ANTIMONIATE (GLUCANTIME) IN THE TREATMENT OF GENERALIZED CUTANEOUS LEISHMANIASIS
Background: Pentavalent antimonials have became of basic importance for the treatment of leishmaniasis. Their most severe side effects have been reported to be increased hepatic enzyme levels and electrocardiographic abnormalities. Nephrotoxicity has been rarely related. Observations: We report a ca...
Main Authors: | , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Universidade de São Paulo (USP)
1999
|
Subjects: | |
Online Access: | https://doaj.org/article/ca8fed0b86064667b96013994c8e6394 |
id |
ftdoajarticles:oai:doaj.org/article:ca8fed0b86064667b96013994c8e6394 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:ca8fed0b86064667b96013994c8e6394 2024-09-09T19:25:28+00:00 NEPHROTOXICITY ATTRIBUTED TO MEGLUMINE ANTIMONIATE (GLUCANTIME) IN THE TREATMENT OF GENERALIZED CUTANEOUS LEISHMANIASIS M.L.O. RODRIGUES R.S. COSTA C.S. SOUZA N.T. FOSS A.M.F. ROSELINO 1999-01-01T00:00:00Z https://doaj.org/article/ca8fed0b86064667b96013994c8e6394 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651999000100007&tlng=en https://doaj.org/toc/1678-9946 1678-9946 https://doaj.org/article/ca8fed0b86064667b96013994c8e6394 Revista do Instituto de Medicina Tropical de São Paulo, Vol 41, Iss 1, Pp 33-37 (1999) Leishmaniasis Antimonials Nephrotoxicity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1999 ftdoajarticles 2024-08-05T17:49:30Z Background: Pentavalent antimonials have became of basic importance for the treatment of leishmaniasis. Their most severe side effects have been reported to be increased hepatic enzyme levels and electrocardiographic abnormalities. Nephrotoxicity has been rarely related. Observations: We report a case of generalized cutaneous leishmaniasis involving a 50-year old male patient who was submitted to treatment with meglumine antimoniate (Glucantime). He developed acute renal failure (ARF) due to acute tubular necrosis (ATN), followed by death after receiving a total of 53 ampoules of Glucantime. Conclusions: The treatment with Glucantime was responsible by ARF diagnosed in this patient. The previous urine osmolarity and serum creatinine levels were normal and the autopsy showed ATN. It should be pointed out if ARF may also be explained by massive deposits of immunocomplexes by leishmania antibodies and antigens due to the antigenic break by the antimonial compound, since our patient presented countless lesions covering the entire tegument, similar to the Hexheimer phenomenon, but at the autopsy no glomerular alterations were seen. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Leishmaniasis Antimonials Nephrotoxicity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Leishmaniasis Antimonials Nephrotoxicity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 M.L.O. RODRIGUES R.S. COSTA C.S. SOUZA N.T. FOSS A.M.F. ROSELINO NEPHROTOXICITY ATTRIBUTED TO MEGLUMINE ANTIMONIATE (GLUCANTIME) IN THE TREATMENT OF GENERALIZED CUTANEOUS LEISHMANIASIS |
topic_facet |
Leishmaniasis Antimonials Nephrotoxicity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Background: Pentavalent antimonials have became of basic importance for the treatment of leishmaniasis. Their most severe side effects have been reported to be increased hepatic enzyme levels and electrocardiographic abnormalities. Nephrotoxicity has been rarely related. Observations: We report a case of generalized cutaneous leishmaniasis involving a 50-year old male patient who was submitted to treatment with meglumine antimoniate (Glucantime). He developed acute renal failure (ARF) due to acute tubular necrosis (ATN), followed by death after receiving a total of 53 ampoules of Glucantime. Conclusions: The treatment with Glucantime was responsible by ARF diagnosed in this patient. The previous urine osmolarity and serum creatinine levels were normal and the autopsy showed ATN. It should be pointed out if ARF may also be explained by massive deposits of immunocomplexes by leishmania antibodies and antigens due to the antigenic break by the antimonial compound, since our patient presented countless lesions covering the entire tegument, similar to the Hexheimer phenomenon, but at the autopsy no glomerular alterations were seen. |
format |
Article in Journal/Newspaper |
author |
M.L.O. RODRIGUES R.S. COSTA C.S. SOUZA N.T. FOSS A.M.F. ROSELINO |
author_facet |
M.L.O. RODRIGUES R.S. COSTA C.S. SOUZA N.T. FOSS A.M.F. ROSELINO |
author_sort |
M.L.O. RODRIGUES |
title |
NEPHROTOXICITY ATTRIBUTED TO MEGLUMINE ANTIMONIATE (GLUCANTIME) IN THE TREATMENT OF GENERALIZED CUTANEOUS LEISHMANIASIS |
title_short |
NEPHROTOXICITY ATTRIBUTED TO MEGLUMINE ANTIMONIATE (GLUCANTIME) IN THE TREATMENT OF GENERALIZED CUTANEOUS LEISHMANIASIS |
title_full |
NEPHROTOXICITY ATTRIBUTED TO MEGLUMINE ANTIMONIATE (GLUCANTIME) IN THE TREATMENT OF GENERALIZED CUTANEOUS LEISHMANIASIS |
title_fullStr |
NEPHROTOXICITY ATTRIBUTED TO MEGLUMINE ANTIMONIATE (GLUCANTIME) IN THE TREATMENT OF GENERALIZED CUTANEOUS LEISHMANIASIS |
title_full_unstemmed |
NEPHROTOXICITY ATTRIBUTED TO MEGLUMINE ANTIMONIATE (GLUCANTIME) IN THE TREATMENT OF GENERALIZED CUTANEOUS LEISHMANIASIS |
title_sort |
nephrotoxicity attributed to meglumine antimoniate (glucantime) in the treatment of generalized cutaneous leishmaniasis |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1999 |
url |
https://doaj.org/article/ca8fed0b86064667b96013994c8e6394 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 41, Iss 1, Pp 33-37 (1999) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651999000100007&tlng=en https://doaj.org/toc/1678-9946 1678-9946 https://doaj.org/article/ca8fed0b86064667b96013994c8e6394 |
_version_ |
1809895253399830528 |