Coxiella burnetii in humans and ticks in rural Senegal.
Background Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts. Methodology/principal findings We investigated Q fever in rural Senegal. Human samples (e.g., sera, saliva, breast milk, feces) were scree...
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ftdoajarticles:oai:doaj.org/article:ca30843d136849cb9446395532fa0cb0 2023-05-15T15:08:11+02:00 Coxiella burnetii in humans and ticks in rural Senegal. Oleg Mediannikov Florence Fenollar Cristina Socolovschi Georges Diatta Hubert Bassene Jean-François Molez Cheikh Sokhna Jean-François Trape Didier Raoult 2010-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000654 https://doaj.org/article/ca30843d136849cb9446395532fa0cb0 EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20386603/pdf/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000654 https://doaj.org/article/ca30843d136849cb9446395532fa0cb0 PLoS Neglected Tropical Diseases, Vol 4, Iss 4, p e654 (2010) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000654 2022-12-30T19:28:45Z Background Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts. Methodology/principal findings We investigated Q fever in rural Senegal. Human samples (e.g., sera, saliva, breast milk, feces) were screened in the generally healthy population of two villages of the Sine-Saloum region. Ticks were collected in four regions. Seroprevalence was studied by immunofluorescence, and all other samples were tested by two qPCR systems for detection of C. burnetii. Positive samples were genotyped (multispacer typing) by amplification and sequencing of three spacers. Strains were isolated by cell culture. We found that the seroprevalence may be as high as 24.5% (59 of 238 studied) in Dielmo village. We identified spontaneous excretion of C. burnetii by humans through faeces and milk. Hard and soft ticks (8 species) were infected in 0-37.6%. We identified three genotypes of C. burnetii. The previously identified genotype 6 was the most common in ticks in all studied regions and the only one found in human samples. Three strains of genotype 6 of C. burnetii were also recovered from soft tick Ornithodoros sonrai. Two other genotypes found in ticks, 35 and 36, were identified for the first time. Conclusions/significance Q fever should be considered a significant public health threat in Senegal. Humans, similar to other mammals, may continuously excrete C. burnetii. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 4 4 e654 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Oleg Mediannikov Florence Fenollar Cristina Socolovschi Georges Diatta Hubert Bassene Jean-François Molez Cheikh Sokhna Jean-François Trape Didier Raoult Coxiella burnetii in humans and ticks in rural Senegal. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts. Methodology/principal findings We investigated Q fever in rural Senegal. Human samples (e.g., sera, saliva, breast milk, feces) were screened in the generally healthy population of two villages of the Sine-Saloum region. Ticks were collected in four regions. Seroprevalence was studied by immunofluorescence, and all other samples were tested by two qPCR systems for detection of C. burnetii. Positive samples were genotyped (multispacer typing) by amplification and sequencing of three spacers. Strains were isolated by cell culture. We found that the seroprevalence may be as high as 24.5% (59 of 238 studied) in Dielmo village. We identified spontaneous excretion of C. burnetii by humans through faeces and milk. Hard and soft ticks (8 species) were infected in 0-37.6%. We identified three genotypes of C. burnetii. The previously identified genotype 6 was the most common in ticks in all studied regions and the only one found in human samples. Three strains of genotype 6 of C. burnetii were also recovered from soft tick Ornithodoros sonrai. Two other genotypes found in ticks, 35 and 36, were identified for the first time. Conclusions/significance Q fever should be considered a significant public health threat in Senegal. Humans, similar to other mammals, may continuously excrete C. burnetii. |
format |
Article in Journal/Newspaper |
author |
Oleg Mediannikov Florence Fenollar Cristina Socolovschi Georges Diatta Hubert Bassene Jean-François Molez Cheikh Sokhna Jean-François Trape Didier Raoult |
author_facet |
Oleg Mediannikov Florence Fenollar Cristina Socolovschi Georges Diatta Hubert Bassene Jean-François Molez Cheikh Sokhna Jean-François Trape Didier Raoult |
author_sort |
Oleg Mediannikov |
title |
Coxiella burnetii in humans and ticks in rural Senegal. |
title_short |
Coxiella burnetii in humans and ticks in rural Senegal. |
title_full |
Coxiella burnetii in humans and ticks in rural Senegal. |
title_fullStr |
Coxiella burnetii in humans and ticks in rural Senegal. |
title_full_unstemmed |
Coxiella burnetii in humans and ticks in rural Senegal. |
title_sort |
coxiella burnetii in humans and ticks in rural senegal. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pntd.0000654 https://doaj.org/article/ca30843d136849cb9446395532fa0cb0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
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Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 4, Iss 4, p e654 (2010) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20386603/pdf/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000654 https://doaj.org/article/ca30843d136849cb9446395532fa0cb0 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000654 |
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PLoS Neglected Tropical Diseases |
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