Autoantibodies before, during and after administration of recombinant interferon-alpha for chronic viral hepatitis Estudo dos auto-anticorpos nas Hepatites virais crônicas B e C antes, durante e após tratamento com Interferon-alfa
This study was undertaken to investigate the presence of autoantibodies in patients with chronic viral hepatitis B and C, before, during and after interferon-alpha (IFN-alpha) therapy and to study their relation to dose and type of IFN-alpha and response to treatment. Fifty patients with chronic hep...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
1995
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ftdoajarticles:oai:doaj.org/article:ca2a0773ac5146729e096bf39b943278 2024-09-09T19:28:34+00:00 Autoantibodies before, during and after administration of recombinant interferon-alpha for chronic viral hepatitis Estudo dos auto-anticorpos nas Hepatites virais crônicas B e C antes, durante e após tratamento com Interferon-alfa Edmundo P.A. Lopes A. Eduardo Silva Hoel Sette Junior Rubens X. Guimarães M. Lucia Ferraz 1995-10-01T00:00:00Z https://doi.org/10.1590/S0036-46651995000500012 https://doaj.org/article/ca2a0773ac5146729e096bf39b943278 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651995000500012 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651995000500012 0036-4665 1678-9946 https://doaj.org/article/ca2a0773ac5146729e096bf39b943278 Revista do Instituto de Medicina Tropical de São Paulo, Vol 37, Iss 5, Pp 455-460 (1995) Viral hepatitis Autoantibodies Interferon-alpha Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1995 ftdoajarticles https://doi.org/10.1590/S0036-46651995000500012 2024-08-05T17:49:30Z This study was undertaken to investigate the presence of autoantibodies in patients with chronic viral hepatitis B and C, before, during and after interferon-alpha (IFN-alpha) therapy and to study their relation to dose and type of IFN-alpha and response to treatment. Fifty patients with chronic hepatitis were divided in two groups, a control-group of 21 patients (10 type B and 11 type C) who were followed for 6 months without treatment and an IFN-group consisting of 29 patients (8 type B and 21 type C) who received IFN therapy for 6 months. Serum samples were tested for a range of antibodies at the start of the study, during therapy and at the end of the 6 month period. Antibodies tested for included: antinuclear, smooth muscle, antimitochondrial, parietal cell and thyroid microsomal. Four (8%) of the total patient group had autoantibodies at the beginning of the study (two in each group). During the follow-up period no patient in the control group developed antibodies compared with 3 (11%) patients in the treatment group. Autoantibodies developed in patients treated with higher doses of IFN and were found in those patients who tended to show a poor response to IFN-therapy. Further studies are needed to establish the relationship between poor response to IFN-alpha and development of autoantibodies. Este estudo teve como objetivo avaliar a presença de auto-anticorpos em pacientes com hepatite crônica pelos vírus B e C, antes, durante e após tratamento com interferon-alfa (IFN-alfa), assim como estudar a relação destes anticorpos com o tipo de IFN, com a dose e com a resposta terapêutica. Cinqüenta pacientes com hepatite viral crônica foram divididos em 2 grupos: grupo-controle constituído por 21 pacientes (10 hepatites B e 11 hepatites C), que foram seguidos durante 6 meses sem tratamento e grupo-IFN constituído por 29 pacientes (8 hepatites B e 21 hepatites C), que receberam IFN-alfa durante 6 meses. Anticorpos antinúcleo, antimúsculo liso, antimitocôndria, anticélula parietal e antitireóide foram pesquisados ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 37 5 455 460 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Viral hepatitis Autoantibodies Interferon-alpha Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Viral hepatitis Autoantibodies Interferon-alpha Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Edmundo P.A. Lopes A. Eduardo Silva Hoel Sette Junior Rubens X. Guimarães M. Lucia Ferraz Autoantibodies before, during and after administration of recombinant interferon-alpha for chronic viral hepatitis Estudo dos auto-anticorpos nas Hepatites virais crônicas B e C antes, durante e após tratamento com Interferon-alfa |
topic_facet |
Viral hepatitis Autoantibodies Interferon-alpha Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
This study was undertaken to investigate the presence of autoantibodies in patients with chronic viral hepatitis B and C, before, during and after interferon-alpha (IFN-alpha) therapy and to study their relation to dose and type of IFN-alpha and response to treatment. Fifty patients with chronic hepatitis were divided in two groups, a control-group of 21 patients (10 type B and 11 type C) who were followed for 6 months without treatment and an IFN-group consisting of 29 patients (8 type B and 21 type C) who received IFN therapy for 6 months. Serum samples were tested for a range of antibodies at the start of the study, during therapy and at the end of the 6 month period. Antibodies tested for included: antinuclear, smooth muscle, antimitochondrial, parietal cell and thyroid microsomal. Four (8%) of the total patient group had autoantibodies at the beginning of the study (two in each group). During the follow-up period no patient in the control group developed antibodies compared with 3 (11%) patients in the treatment group. Autoantibodies developed in patients treated with higher doses of IFN and were found in those patients who tended to show a poor response to IFN-therapy. Further studies are needed to establish the relationship between poor response to IFN-alpha and development of autoantibodies. Este estudo teve como objetivo avaliar a presença de auto-anticorpos em pacientes com hepatite crônica pelos vírus B e C, antes, durante e após tratamento com interferon-alfa (IFN-alfa), assim como estudar a relação destes anticorpos com o tipo de IFN, com a dose e com a resposta terapêutica. Cinqüenta pacientes com hepatite viral crônica foram divididos em 2 grupos: grupo-controle constituído por 21 pacientes (10 hepatites B e 11 hepatites C), que foram seguidos durante 6 meses sem tratamento e grupo-IFN constituído por 29 pacientes (8 hepatites B e 21 hepatites C), que receberam IFN-alfa durante 6 meses. Anticorpos antinúcleo, antimúsculo liso, antimitocôndria, anticélula parietal e antitireóide foram pesquisados ... |
format |
Article in Journal/Newspaper |
author |
Edmundo P.A. Lopes A. Eduardo Silva Hoel Sette Junior Rubens X. Guimarães M. Lucia Ferraz |
author_facet |
Edmundo P.A. Lopes A. Eduardo Silva Hoel Sette Junior Rubens X. Guimarães M. Lucia Ferraz |
author_sort |
Edmundo P.A. Lopes |
title |
Autoantibodies before, during and after administration of recombinant interferon-alpha for chronic viral hepatitis Estudo dos auto-anticorpos nas Hepatites virais crônicas B e C antes, durante e após tratamento com Interferon-alfa |
title_short |
Autoantibodies before, during and after administration of recombinant interferon-alpha for chronic viral hepatitis Estudo dos auto-anticorpos nas Hepatites virais crônicas B e C antes, durante e após tratamento com Interferon-alfa |
title_full |
Autoantibodies before, during and after administration of recombinant interferon-alpha for chronic viral hepatitis Estudo dos auto-anticorpos nas Hepatites virais crônicas B e C antes, durante e após tratamento com Interferon-alfa |
title_fullStr |
Autoantibodies before, during and after administration of recombinant interferon-alpha for chronic viral hepatitis Estudo dos auto-anticorpos nas Hepatites virais crônicas B e C antes, durante e após tratamento com Interferon-alfa |
title_full_unstemmed |
Autoantibodies before, during and after administration of recombinant interferon-alpha for chronic viral hepatitis Estudo dos auto-anticorpos nas Hepatites virais crônicas B e C antes, durante e após tratamento com Interferon-alfa |
title_sort |
autoantibodies before, during and after administration of recombinant interferon-alpha for chronic viral hepatitis estudo dos auto-anticorpos nas hepatites virais crônicas b e c antes, durante e após tratamento com interferon-alfa |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1995 |
url |
https://doi.org/10.1590/S0036-46651995000500012 https://doaj.org/article/ca2a0773ac5146729e096bf39b943278 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 37, Iss 5, Pp 455-460 (1995) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651995000500012 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651995000500012 0036-4665 1678-9946 https://doaj.org/article/ca2a0773ac5146729e096bf39b943278 |
op_doi |
https://doi.org/10.1590/S0036-46651995000500012 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
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37 |
container_issue |
5 |
container_start_page |
455 |
op_container_end_page |
460 |
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