Serum levels of interleukin-6 are linked to the severity of the disease caused by Andes Virus.
Andes virus (ANDV) is the etiological agent of hantavirus cardiopulmonary syndrome in Chile. In this study, we evaluated the profile of the pro-inflammatory cytokines IL-1β, IL-12p70, IL-21, TNF-α, IFN-γ, IL-10 and IL-6 in serum samples of ANDV-infected patients at the time of hospitalization. The m...
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ftdoajarticles:oai:doaj.org/article:ca036d3e76d148c6bf7fe35d60d0ccb0 2023-05-15T15:09:19+02:00 Serum levels of interleukin-6 are linked to the severity of the disease caused by Andes Virus. Jenniffer Angulo Constanza Martínez-Valdebenito Claudia Marco Héctor Galeno Eliecer Villagra Lilian Vera Natalia Lagos Natalia Becerra Judith Mora Andrea Bermúdez Janepsy Díaz Marcela Ferrés Marcelo López-Lastra 2017-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005757 https://doaj.org/article/ca036d3e76d148c6bf7fe35d60d0ccb0 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5529019?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005757 https://doaj.org/article/ca036d3e76d148c6bf7fe35d60d0ccb0 PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005757 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005757 2022-12-31T01:32:52Z Andes virus (ANDV) is the etiological agent of hantavirus cardiopulmonary syndrome in Chile. In this study, we evaluated the profile of the pro-inflammatory cytokines IL-1β, IL-12p70, IL-21, TNF-α, IFN-γ, IL-10 and IL-6 in serum samples of ANDV-infected patients at the time of hospitalization. The mean levels of circulating cytokines were determined by a Bead-Based Multiplex assay coupled with Luminex detection technology, in order to compare 43 serum samples of healthy controls and 43 samples of ANDV-infected patients that had been categorized according to the severity of disease. When compared to the controls, no significant differences in IL-1β concentration were observed in ANDV-infected patients (p = 0.9672), whereas levels of IL-12p70 and IL-21 were significantly lower in infected cases (p = <0.0001). Significantly elevated levels of TNF-α, IFN-γ, IL-10, and IL-6 were detected in ANDV-infected individuals (p = <0.0001, 0.0036, <0.0001, <0.0001, respectively). Notably, IL-6 levels were significantly higher (40-fold) in the 22 patients with severe symptoms compared to the 21 individuals with mild symptoms (p = <0.0001). Using multivariate regression models, we show that IL-6 levels has a crude OR of 14.4 (CI: 3.3-63.1). In conclusion, the serum level of IL-6 is a significant predictor of the severity of the clinical outcome of ANDV-induced disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 7 e0005757 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jenniffer Angulo Constanza Martínez-Valdebenito Claudia Marco Héctor Galeno Eliecer Villagra Lilian Vera Natalia Lagos Natalia Becerra Judith Mora Andrea Bermúdez Janepsy Díaz Marcela Ferrés Marcelo López-Lastra Serum levels of interleukin-6 are linked to the severity of the disease caused by Andes Virus. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Andes virus (ANDV) is the etiological agent of hantavirus cardiopulmonary syndrome in Chile. In this study, we evaluated the profile of the pro-inflammatory cytokines IL-1β, IL-12p70, IL-21, TNF-α, IFN-γ, IL-10 and IL-6 in serum samples of ANDV-infected patients at the time of hospitalization. The mean levels of circulating cytokines were determined by a Bead-Based Multiplex assay coupled with Luminex detection technology, in order to compare 43 serum samples of healthy controls and 43 samples of ANDV-infected patients that had been categorized according to the severity of disease. When compared to the controls, no significant differences in IL-1β concentration were observed in ANDV-infected patients (p = 0.9672), whereas levels of IL-12p70 and IL-21 were significantly lower in infected cases (p = <0.0001). Significantly elevated levels of TNF-α, IFN-γ, IL-10, and IL-6 were detected in ANDV-infected individuals (p = <0.0001, 0.0036, <0.0001, <0.0001, respectively). Notably, IL-6 levels were significantly higher (40-fold) in the 22 patients with severe symptoms compared to the 21 individuals with mild symptoms (p = <0.0001). Using multivariate regression models, we show that IL-6 levels has a crude OR of 14.4 (CI: 3.3-63.1). In conclusion, the serum level of IL-6 is a significant predictor of the severity of the clinical outcome of ANDV-induced disease. |
format |
Article in Journal/Newspaper |
author |
Jenniffer Angulo Constanza Martínez-Valdebenito Claudia Marco Héctor Galeno Eliecer Villagra Lilian Vera Natalia Lagos Natalia Becerra Judith Mora Andrea Bermúdez Janepsy Díaz Marcela Ferrés Marcelo López-Lastra |
author_facet |
Jenniffer Angulo Constanza Martínez-Valdebenito Claudia Marco Héctor Galeno Eliecer Villagra Lilian Vera Natalia Lagos Natalia Becerra Judith Mora Andrea Bermúdez Janepsy Díaz Marcela Ferrés Marcelo López-Lastra |
author_sort |
Jenniffer Angulo |
title |
Serum levels of interleukin-6 are linked to the severity of the disease caused by Andes Virus. |
title_short |
Serum levels of interleukin-6 are linked to the severity of the disease caused by Andes Virus. |
title_full |
Serum levels of interleukin-6 are linked to the severity of the disease caused by Andes Virus. |
title_fullStr |
Serum levels of interleukin-6 are linked to the severity of the disease caused by Andes Virus. |
title_full_unstemmed |
Serum levels of interleukin-6 are linked to the severity of the disease caused by Andes Virus. |
title_sort |
serum levels of interleukin-6 are linked to the severity of the disease caused by andes virus. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005757 https://doaj.org/article/ca036d3e76d148c6bf7fe35d60d0ccb0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005757 (2017) |
op_relation |
http://europepmc.org/articles/PMC5529019?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005757 https://doaj.org/article/ca036d3e76d148c6bf7fe35d60d0ccb0 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005757 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
7 |
container_start_page |
e0005757 |
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1766340538298007552 |