Green Production of a High-Value Branched-Chain Diester: Optimization Based on Operating Conditions and Economic and Sustainability Criteria
Branched-chain esters (BCEs) have found a large number of applications in cosmetics. Among them, neopentyl glycol dilaurate (NPGDL) stands out as an emollient, emulsifier, and skin-conditioning agent. This work presents the synthesis of NPGDL in a solvent-free medium using the two most common immobi...
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ftdoajarticles:oai:doaj.org/article:c93b2d980aa2463689ddcd52e4fae8cc 2023-06-11T04:06:41+02:00 Green Production of a High-Value Branched-Chain Diester: Optimization Based on Operating Conditions and Economic and Sustainability Criteria Claudia Montiel Silvia Gimeno-Martos Salvadora Ortega-Requena Mar Serrano-Arnaldos Fuensanta Máximo Josefa Bastida 2023-05-01T00:00:00Z https://doi.org/10.3390/app13106177 https://doaj.org/article/c93b2d980aa2463689ddcd52e4fae8cc EN eng MDPI AG https://www.mdpi.com/2076-3417/13/10/6177 https://doaj.org/toc/2076-3417 doi:10.3390/app13106177 2076-3417 https://doaj.org/article/c93b2d980aa2463689ddcd52e4fae8cc Applied Sciences, Vol 13, Iss 6177, p 6177 (2023) Candida antarctica lipase Rhizomucor miehei lipase solvent-free neopentyl glycol dilaurate esterification economic assessment Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 article 2023 ftdoajarticles https://doi.org/10.3390/app13106177 2023-05-28T00:34:40Z Branched-chain esters (BCEs) have found a large number of applications in cosmetics. Among them, neopentyl glycol dilaurate (NPGDL) stands out as an emollient, emulsifier, and skin-conditioning agent. This work presents the synthesis of NPGDL in a solvent-free medium using the two most common immobilized lipases: Novozym ® 40086 (Rml) and Novozym ® 435 (CalB). Results proved that the former biocatalyst has lower activity and certain temperature deactivation, although conversions ≥ 90% were obtained at 60 °C and 7.5% of catalyst. On the other hand, optimal reaction conditions for Novozym ® 435 are 3.75% w / w of the immobilized derivative at 80 °C. Under optimal conditions, the process productivities were 0.105 and 0.169 kg NPGDL/L h, respectively. In order to select the best conditions for NPGDL production, studies on the reuse of the derivative and cost estimation have been performed. Economic study shows that biocatalytic processes can be competitive when lipases are reused for five cycles, yielding biocatalyst productivities of 56 and 122 kg NPGDL/kg biocatalyst using Novozym ® 40086 and Novozym ® 435, respectively. The final choice will be based on both economic and sustainability criteria. Green metric values using both biocatalysts are similar but the product obtained using Novozym ® 40086 is 20% cheaper, making this alternative the best option. Article in Journal/Newspaper Antarc* Antarctica Directory of Open Access Journals: DOAJ Articles Applied Sciences 13 10 6177 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Candida antarctica lipase Rhizomucor miehei lipase solvent-free neopentyl glycol dilaurate esterification economic assessment Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 |
spellingShingle |
Candida antarctica lipase Rhizomucor miehei lipase solvent-free neopentyl glycol dilaurate esterification economic assessment Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Claudia Montiel Silvia Gimeno-Martos Salvadora Ortega-Requena Mar Serrano-Arnaldos Fuensanta Máximo Josefa Bastida Green Production of a High-Value Branched-Chain Diester: Optimization Based on Operating Conditions and Economic and Sustainability Criteria |
topic_facet |
Candida antarctica lipase Rhizomucor miehei lipase solvent-free neopentyl glycol dilaurate esterification economic assessment Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 |
description |
Branched-chain esters (BCEs) have found a large number of applications in cosmetics. Among them, neopentyl glycol dilaurate (NPGDL) stands out as an emollient, emulsifier, and skin-conditioning agent. This work presents the synthesis of NPGDL in a solvent-free medium using the two most common immobilized lipases: Novozym ® 40086 (Rml) and Novozym ® 435 (CalB). Results proved that the former biocatalyst has lower activity and certain temperature deactivation, although conversions ≥ 90% were obtained at 60 °C and 7.5% of catalyst. On the other hand, optimal reaction conditions for Novozym ® 435 are 3.75% w / w of the immobilized derivative at 80 °C. Under optimal conditions, the process productivities were 0.105 and 0.169 kg NPGDL/L h, respectively. In order to select the best conditions for NPGDL production, studies on the reuse of the derivative and cost estimation have been performed. Economic study shows that biocatalytic processes can be competitive when lipases are reused for five cycles, yielding biocatalyst productivities of 56 and 122 kg NPGDL/kg biocatalyst using Novozym ® 40086 and Novozym ® 435, respectively. The final choice will be based on both economic and sustainability criteria. Green metric values using both biocatalysts are similar but the product obtained using Novozym ® 40086 is 20% cheaper, making this alternative the best option. |
format |
Article in Journal/Newspaper |
author |
Claudia Montiel Silvia Gimeno-Martos Salvadora Ortega-Requena Mar Serrano-Arnaldos Fuensanta Máximo Josefa Bastida |
author_facet |
Claudia Montiel Silvia Gimeno-Martos Salvadora Ortega-Requena Mar Serrano-Arnaldos Fuensanta Máximo Josefa Bastida |
author_sort |
Claudia Montiel |
title |
Green Production of a High-Value Branched-Chain Diester: Optimization Based on Operating Conditions and Economic and Sustainability Criteria |
title_short |
Green Production of a High-Value Branched-Chain Diester: Optimization Based on Operating Conditions and Economic and Sustainability Criteria |
title_full |
Green Production of a High-Value Branched-Chain Diester: Optimization Based on Operating Conditions and Economic and Sustainability Criteria |
title_fullStr |
Green Production of a High-Value Branched-Chain Diester: Optimization Based on Operating Conditions and Economic and Sustainability Criteria |
title_full_unstemmed |
Green Production of a High-Value Branched-Chain Diester: Optimization Based on Operating Conditions and Economic and Sustainability Criteria |
title_sort |
green production of a high-value branched-chain diester: optimization based on operating conditions and economic and sustainability criteria |
publisher |
MDPI AG |
publishDate |
2023 |
url |
https://doi.org/10.3390/app13106177 https://doaj.org/article/c93b2d980aa2463689ddcd52e4fae8cc |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Applied Sciences, Vol 13, Iss 6177, p 6177 (2023) |
op_relation |
https://www.mdpi.com/2076-3417/13/10/6177 https://doaj.org/toc/2076-3417 doi:10.3390/app13106177 2076-3417 https://doaj.org/article/c93b2d980aa2463689ddcd52e4fae8cc |
op_doi |
https://doi.org/10.3390/app13106177 |
container_title |
Applied Sciences |
container_volume |
13 |
container_issue |
10 |
container_start_page |
6177 |
_version_ |
1768378752509673472 |