Astroviruses in terrestrial Malagasy mammals.
Small terrestrial mammals are major hosts of infectious agents responsible for zoonotic diseases. Astroviruses (AstVs)-the cause of non-bacterial gastroenteritis mainly affecting young children-have been detected in a wide array of mammalian and avian host species. However, understanding the factors...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2024
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0012263 https://doaj.org/article/c85ada122b4844fc9d70d34a04299496 |
id |
ftdoajarticles:oai:doaj.org/article:c85ada122b4844fc9d70d34a04299496 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:c85ada122b4844fc9d70d34a04299496 2024-09-15T18:32:05+00:00 Astroviruses in terrestrial Malagasy mammals. Victoria Carcauzon James P Herrera Kayla Kaufman Fiona Baudino Natalie Wickenkamp Toky M Randriamoria Voahangy Soarimalala Steven M Goodman Charles L Nunn Camille Lebarbenchon Pablo Tortosa 2024-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0012263 https://doaj.org/article/c85ada122b4844fc9d70d34a04299496 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0012263 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0012263 https://doaj.org/article/c85ada122b4844fc9d70d34a04299496 PLoS Neglected Tropical Diseases, Vol 18, Iss 6, p e0012263 (2024) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2024 ftdoajarticles https://doi.org/10.1371/journal.pntd.0012263 2024-08-05T17:48:49Z Small terrestrial mammals are major hosts of infectious agents responsible for zoonotic diseases. Astroviruses (AstVs)-the cause of non-bacterial gastroenteritis mainly affecting young children-have been detected in a wide array of mammalian and avian host species. However, understanding the factors that influence AstV infection within and across hosts is limited. Here, we investigated the impact of land use changes on AstVs in terrestrial small mammals in rural northeastern Madagascar. We sampled 515 small mammals, representing seven endemic and four introduced species. Twenty-two positive samples were identified, all but one of which were found in the introduced species Mus musculus and Rattus rattus (family Muridae), with a positivity rate of 7.7% (6/78) and 5.6% (15/266), respectively. The non-introduced rodent case was from an endemic shrew-tenrec (family Tenrecidae). We found the highest positivity rate of AstVs infection in brushy regrowth (17.5%, 7/40) as compared to flooded rice fields (4.60%, 8/174), secondary forest (4.1%, 3/74), agroforest (3.6%, 1/28), village (2.61%, 3/115), and semi-intact forest (0%, 0/84). A phylogenetic analysis revealed an association between AstVs and their rodent host species. None of the viruses were phylogenetically related to AstVs previously described in Malagasy bats. This study supports AstV circulation in synanthropic animals in agricultural habitats of Madagascar and highlights the need to assess the spillover risk to human populations in rural areas. Article in Journal/Newspaper Rattus rattus Directory of Open Access Journals: DOAJ Articles PLOS Neglected Tropical Diseases 18 6 e0012263 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Victoria Carcauzon James P Herrera Kayla Kaufman Fiona Baudino Natalie Wickenkamp Toky M Randriamoria Voahangy Soarimalala Steven M Goodman Charles L Nunn Camille Lebarbenchon Pablo Tortosa Astroviruses in terrestrial Malagasy mammals. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Small terrestrial mammals are major hosts of infectious agents responsible for zoonotic diseases. Astroviruses (AstVs)-the cause of non-bacterial gastroenteritis mainly affecting young children-have been detected in a wide array of mammalian and avian host species. However, understanding the factors that influence AstV infection within and across hosts is limited. Here, we investigated the impact of land use changes on AstVs in terrestrial small mammals in rural northeastern Madagascar. We sampled 515 small mammals, representing seven endemic and four introduced species. Twenty-two positive samples were identified, all but one of which were found in the introduced species Mus musculus and Rattus rattus (family Muridae), with a positivity rate of 7.7% (6/78) and 5.6% (15/266), respectively. The non-introduced rodent case was from an endemic shrew-tenrec (family Tenrecidae). We found the highest positivity rate of AstVs infection in brushy regrowth (17.5%, 7/40) as compared to flooded rice fields (4.60%, 8/174), secondary forest (4.1%, 3/74), agroforest (3.6%, 1/28), village (2.61%, 3/115), and semi-intact forest (0%, 0/84). A phylogenetic analysis revealed an association between AstVs and their rodent host species. None of the viruses were phylogenetically related to AstVs previously described in Malagasy bats. This study supports AstV circulation in synanthropic animals in agricultural habitats of Madagascar and highlights the need to assess the spillover risk to human populations in rural areas. |
format |
Article in Journal/Newspaper |
author |
Victoria Carcauzon James P Herrera Kayla Kaufman Fiona Baudino Natalie Wickenkamp Toky M Randriamoria Voahangy Soarimalala Steven M Goodman Charles L Nunn Camille Lebarbenchon Pablo Tortosa |
author_facet |
Victoria Carcauzon James P Herrera Kayla Kaufman Fiona Baudino Natalie Wickenkamp Toky M Randriamoria Voahangy Soarimalala Steven M Goodman Charles L Nunn Camille Lebarbenchon Pablo Tortosa |
author_sort |
Victoria Carcauzon |
title |
Astroviruses in terrestrial Malagasy mammals. |
title_short |
Astroviruses in terrestrial Malagasy mammals. |
title_full |
Astroviruses in terrestrial Malagasy mammals. |
title_fullStr |
Astroviruses in terrestrial Malagasy mammals. |
title_full_unstemmed |
Astroviruses in terrestrial Malagasy mammals. |
title_sort |
astroviruses in terrestrial malagasy mammals. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2024 |
url |
https://doi.org/10.1371/journal.pntd.0012263 https://doaj.org/article/c85ada122b4844fc9d70d34a04299496 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
PLoS Neglected Tropical Diseases, Vol 18, Iss 6, p e0012263 (2024) |
op_relation |
https://doi.org/10.1371/journal.pntd.0012263 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0012263 https://doaj.org/article/c85ada122b4844fc9d70d34a04299496 |
op_doi |
https://doi.org/10.1371/journal.pntd.0012263 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
18 |
container_issue |
6 |
container_start_page |
e0012263 |
_version_ |
1810473842848563200 |