A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand.
A sustained outbreak of leptospirosis occurred in northeast Thailand between 1999 and 2003, the basis for which was unknown.A prospective study was conducted between 2000 and 2005 to identify patients with leptospirosis presenting to Udon Thani Hospital in northeast Thailand, and to isolate the caus...
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ftdoajarticles:oai:doaj.org/article:c7d5625bdd9e4c2cb450f50e1806c8b7 2023-05-15T15:09:29+02:00 A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand. Janjira Thaipadungpanit Vanaporn Wuthiekanun Wirongrong Chierakul Lee D Smythe Wimol Petkanchanapong Roongrueng Limpaiboon Apichat Apiwatanaporn Andrew T Slack Yupin Suputtamongkol Nicholas J White Edward J Feil Nicholas P J Day Sharon J Peacock 2007-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000056 https://doaj.org/article/c7d5625bdd9e4c2cb450f50e1806c8b7 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2041815?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000056 https://doaj.org/article/c7d5625bdd9e4c2cb450f50e1806c8b7 PLoS Neglected Tropical Diseases, Vol 1, Iss 1, p e56 (2007) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2007 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000056 2022-12-30T23:19:51Z A sustained outbreak of leptospirosis occurred in northeast Thailand between 1999 and 2003, the basis for which was unknown.A prospective study was conducted between 2000 and 2005 to identify patients with leptospirosis presenting to Udon Thani Hospital in northeast Thailand, and to isolate the causative organisms from blood. A multilocus sequence typing scheme was developed to genotype these pathogenic Leptospira. Additional typing was performed for Leptospira isolated from human cases in other Thai provinces over the same period, and from rodents captured in the northeast during 2004. Sequence types (STs) were compared with those of Leptospira drawn from a reference collection. Twelve STs were identified among 101 isolates from patients in Udon Thani. One of these (ST34) accounted for 77 (76%) of isolates. ST34 was Leptospira interrogans, serovar Autumnalis. 86% of human Leptospira isolates from Udon Thani corresponded to ST34 in 2000/2001, but this figure fell to 56% by 2005 as the outbreak waned (p = 0.01). ST34 represented 17/24 (71%) of human isolates from other Thai provinces, and 7/8 (88%) rodent isolates. By contrast, 59 STs were found among 76 reference strains, indicating a much more diverse population genetic structure; ST34 was not identified in this collection.Development of an MLST scheme for Leptospira interrogans revealed that a single ecologically successful pathogenic clone of L. interrogans predominated in the rodent population, and was associated with a sustained outbreak of human leptospirosis in Thailand. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 1 1 e56 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Janjira Thaipadungpanit Vanaporn Wuthiekanun Wirongrong Chierakul Lee D Smythe Wimol Petkanchanapong Roongrueng Limpaiboon Apichat Apiwatanaporn Andrew T Slack Yupin Suputtamongkol Nicholas J White Edward J Feil Nicholas P J Day Sharon J Peacock A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
A sustained outbreak of leptospirosis occurred in northeast Thailand between 1999 and 2003, the basis for which was unknown.A prospective study was conducted between 2000 and 2005 to identify patients with leptospirosis presenting to Udon Thani Hospital in northeast Thailand, and to isolate the causative organisms from blood. A multilocus sequence typing scheme was developed to genotype these pathogenic Leptospira. Additional typing was performed for Leptospira isolated from human cases in other Thai provinces over the same period, and from rodents captured in the northeast during 2004. Sequence types (STs) were compared with those of Leptospira drawn from a reference collection. Twelve STs were identified among 101 isolates from patients in Udon Thani. One of these (ST34) accounted for 77 (76%) of isolates. ST34 was Leptospira interrogans, serovar Autumnalis. 86% of human Leptospira isolates from Udon Thani corresponded to ST34 in 2000/2001, but this figure fell to 56% by 2005 as the outbreak waned (p = 0.01). ST34 represented 17/24 (71%) of human isolates from other Thai provinces, and 7/8 (88%) rodent isolates. By contrast, 59 STs were found among 76 reference strains, indicating a much more diverse population genetic structure; ST34 was not identified in this collection.Development of an MLST scheme for Leptospira interrogans revealed that a single ecologically successful pathogenic clone of L. interrogans predominated in the rodent population, and was associated with a sustained outbreak of human leptospirosis in Thailand. |
format |
Article in Journal/Newspaper |
author |
Janjira Thaipadungpanit Vanaporn Wuthiekanun Wirongrong Chierakul Lee D Smythe Wimol Petkanchanapong Roongrueng Limpaiboon Apichat Apiwatanaporn Andrew T Slack Yupin Suputtamongkol Nicholas J White Edward J Feil Nicholas P J Day Sharon J Peacock |
author_facet |
Janjira Thaipadungpanit Vanaporn Wuthiekanun Wirongrong Chierakul Lee D Smythe Wimol Petkanchanapong Roongrueng Limpaiboon Apichat Apiwatanaporn Andrew T Slack Yupin Suputtamongkol Nicholas J White Edward J Feil Nicholas P J Day Sharon J Peacock |
author_sort |
Janjira Thaipadungpanit |
title |
A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand. |
title_short |
A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand. |
title_full |
A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand. |
title_fullStr |
A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand. |
title_full_unstemmed |
A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand. |
title_sort |
dominant clone of leptospira interrogans associated with an outbreak of human leptospirosis in thailand. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2007 |
url |
https://doi.org/10.1371/journal.pntd.0000056 https://doaj.org/article/c7d5625bdd9e4c2cb450f50e1806c8b7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 1, Iss 1, p e56 (2007) |
op_relation |
http://europepmc.org/articles/PMC2041815?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000056 https://doaj.org/article/c7d5625bdd9e4c2cb450f50e1806c8b7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000056 |
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PLoS Neglected Tropical Diseases |
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1 |
container_start_page |
e56 |
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1766340671580405760 |