Myocardial Adiponectin Isoform Shift in Dogs with Congestive Heart Failure—A Comparison to Hibernating Brown Bears (Ursus arctos horribilis)
Adiponectin is the most abundant plasma adipokine, and is well known for its role in energy homeostasis and cardiac protection. In humans with dilated cardiomyopathy, myocardial adiponectin protein expression is reduced compared to normal hearts and has been implicated in the pathology of cardiomyop...
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ftdoajarticles:oai:doaj.org/article:c7cb49e92615468daf0cb90cb4b818ec 2023-05-15T18:42:09+02:00 Myocardial Adiponectin Isoform Shift in Dogs with Congestive Heart Failure—A Comparison to Hibernating Brown Bears (Ursus arctos horribilis) O. Lynne Nelson Rachael M. Wood Jens Häggström Clarence Kvart Charles T. Robbins 2017-07-01T00:00:00Z https://doi.org/10.3390/vetsci4030035 https://doaj.org/article/c7cb49e92615468daf0cb90cb4b818ec EN eng MDPI AG https://www.mdpi.com/2306-7381/4/3/35 https://doaj.org/toc/2306-7381 2306-7381 doi:10.3390/vetsci4030035 https://doaj.org/article/c7cb49e92615468daf0cb90cb4b818ec Veterinary Sciences, Vol 4, Iss 3, p 35 (2017) low molecular weight adiponectin high molecular weight adiponectin chronic valvular heart disease endocardiosis hibernation Veterinary medicine SF600-1100 article 2017 ftdoajarticles https://doi.org/10.3390/vetsci4030035 2022-12-31T09:39:17Z Adiponectin is the most abundant plasma adipokine, and is well known for its role in energy homeostasis and cardiac protection. In humans with dilated cardiomyopathy, myocardial adiponectin protein expression is reduced compared to normal hearts and has been implicated in the pathology of cardiomyopathy. Serum adiponectin levels are often conflicting, with higher levels associated with poor survival in humans with congestive heart failure (CHF). We evaluated adiponectin serum concentrations and myocardial protein expression in dogs with naturally occurring myxomatous mitral valve disease and CHF. We compared the findings to active and hibernating brown bears as bears are adapted to endure an extreme period of low cardiac output during their annual hibernation. Bears exhibited largely the active high-molecular weight (HMW) versus the low-molecular weight isoforms of myocardial adiponectin (HMW:LMW = 6.3) during both the active period and hibernation, while healthy dogs exhibited a more balanced mix of isoforms. Dogs with CHF expressed predominately HMW isoforms of adiponectin (HMW:LMW = 12.5), appearing more similar to bears. In contrast to humans, serum adiponectin was significantly lower in dogs with CHF and lowest levels in the severest CHF class. In both dogs and bears, myocardial adiponectin was expressed independent of circulating adiponectin concentrations, suggesting a local regulatory mechanism within the heart. Article in Journal/Newspaper Ursus arctos Directory of Open Access Journals: DOAJ Articles Veterinary Sciences 4 4 35 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
low molecular weight adiponectin high molecular weight adiponectin chronic valvular heart disease endocardiosis hibernation Veterinary medicine SF600-1100 |
spellingShingle |
low molecular weight adiponectin high molecular weight adiponectin chronic valvular heart disease endocardiosis hibernation Veterinary medicine SF600-1100 O. Lynne Nelson Rachael M. Wood Jens Häggström Clarence Kvart Charles T. Robbins Myocardial Adiponectin Isoform Shift in Dogs with Congestive Heart Failure—A Comparison to Hibernating Brown Bears (Ursus arctos horribilis) |
topic_facet |
low molecular weight adiponectin high molecular weight adiponectin chronic valvular heart disease endocardiosis hibernation Veterinary medicine SF600-1100 |
description |
Adiponectin is the most abundant plasma adipokine, and is well known for its role in energy homeostasis and cardiac protection. In humans with dilated cardiomyopathy, myocardial adiponectin protein expression is reduced compared to normal hearts and has been implicated in the pathology of cardiomyopathy. Serum adiponectin levels are often conflicting, with higher levels associated with poor survival in humans with congestive heart failure (CHF). We evaluated adiponectin serum concentrations and myocardial protein expression in dogs with naturally occurring myxomatous mitral valve disease and CHF. We compared the findings to active and hibernating brown bears as bears are adapted to endure an extreme period of low cardiac output during their annual hibernation. Bears exhibited largely the active high-molecular weight (HMW) versus the low-molecular weight isoforms of myocardial adiponectin (HMW:LMW = 6.3) during both the active period and hibernation, while healthy dogs exhibited a more balanced mix of isoforms. Dogs with CHF expressed predominately HMW isoforms of adiponectin (HMW:LMW = 12.5), appearing more similar to bears. In contrast to humans, serum adiponectin was significantly lower in dogs with CHF and lowest levels in the severest CHF class. In both dogs and bears, myocardial adiponectin was expressed independent of circulating adiponectin concentrations, suggesting a local regulatory mechanism within the heart. |
format |
Article in Journal/Newspaper |
author |
O. Lynne Nelson Rachael M. Wood Jens Häggström Clarence Kvart Charles T. Robbins |
author_facet |
O. Lynne Nelson Rachael M. Wood Jens Häggström Clarence Kvart Charles T. Robbins |
author_sort |
O. Lynne Nelson |
title |
Myocardial Adiponectin Isoform Shift in Dogs with Congestive Heart Failure—A Comparison to Hibernating Brown Bears (Ursus arctos horribilis) |
title_short |
Myocardial Adiponectin Isoform Shift in Dogs with Congestive Heart Failure—A Comparison to Hibernating Brown Bears (Ursus arctos horribilis) |
title_full |
Myocardial Adiponectin Isoform Shift in Dogs with Congestive Heart Failure—A Comparison to Hibernating Brown Bears (Ursus arctos horribilis) |
title_fullStr |
Myocardial Adiponectin Isoform Shift in Dogs with Congestive Heart Failure—A Comparison to Hibernating Brown Bears (Ursus arctos horribilis) |
title_full_unstemmed |
Myocardial Adiponectin Isoform Shift in Dogs with Congestive Heart Failure—A Comparison to Hibernating Brown Bears (Ursus arctos horribilis) |
title_sort |
myocardial adiponectin isoform shift in dogs with congestive heart failure—a comparison to hibernating brown bears (ursus arctos horribilis) |
publisher |
MDPI AG |
publishDate |
2017 |
url |
https://doi.org/10.3390/vetsci4030035 https://doaj.org/article/c7cb49e92615468daf0cb90cb4b818ec |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
Veterinary Sciences, Vol 4, Iss 3, p 35 (2017) |
op_relation |
https://www.mdpi.com/2306-7381/4/3/35 https://doaj.org/toc/2306-7381 2306-7381 doi:10.3390/vetsci4030035 https://doaj.org/article/c7cb49e92615468daf0cb90cb4b818ec |
op_doi |
https://doi.org/10.3390/vetsci4030035 |
container_title |
Veterinary Sciences |
container_volume |
4 |
container_issue |
4 |
container_start_page |
35 |
_version_ |
1766231761132453888 |