Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study
Objective: To investigate the relation between serum 25-hydroxyvitamin D (s-25(OH)D) and subjective sleep measures in an Arctic population (69°N). Methods: Cross-sectional data was collected from 21,083 individuals (aged ≥40 years) participating in the population based Tromsø Study: Tromsø7 (2015–20...
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ftdoajarticles:oai:doaj.org/article:c7bbe522c04646c4aeb12497a8709535 2023-05-15T14:56:53+02:00 Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study A.U. Larsen L.A. Hopstock R. Jorde G. Grimnes 2022-12-01T00:00:00Z https://doi.org/10.1016/j.sleepx.2022.100056 https://doaj.org/article/c7bbe522c04646c4aeb12497a8709535 EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S2590142722000155 https://doaj.org/toc/2590-1427 2590-1427 doi:10.1016/j.sleepx.2022.100056 https://doaj.org/article/c7bbe522c04646c4aeb12497a8709535 Sleep Medicine: X, Vol 4, Iss , Pp 100056- (2022) Sleep duration Insomnia Excessive daytime sleepiness Vitamin D 25(OH)D Specialties of internal medicine RC581-951 article 2022 ftdoajarticles https://doi.org/10.1016/j.sleepx.2022.100056 2022-12-30T19:49:30Z Objective: To investigate the relation between serum 25-hydroxyvitamin D (s-25(OH)D) and subjective sleep measures in an Arctic population (69°N). Methods: Cross-sectional data was collected from 21,083 individuals (aged ≥40 years) participating in the population based Tromsø Study: Tromsø7 (2015–2016). The present study included 20,438 participants, after having excluded respondents missing data on s-25(OH)D (n = 161) and/or subjective sleep measures (including sleep duration, insomnia, and daytime sleepiness)(n = 490). Based on s-25(OH)D (assessed using LC-MS/MS), participants were grouped as deficient (<30 nmol/L), insufficient (30–49.9 nmol/L), sufficient (50–75 nmol/L), or high (>75 nmol/L). Sleep duration was grouped as inadequate (ISD) if < 7 or ≥9 h. Linear and logistic regression were used to calculate unstandardized β-values and odds ratios [95% confidence intervals]. The analyses were adjusted for season, age, BMI, lifestyle factors and relevant comorbidities. Results: In both men and women, s-25(OH)D was positively associated with sleep duration, and compared to the sufficient s-25(OH)D group, the insufficient s-25(OH)D group reported significantly shorter sleep duration in both sexes. There was an increased odds of ISD in both men and women but adjusted for confounding factors this was only significant in women (1.16 [1.03, 1.32], p = .017). In men, there were no significant associations between s-25(OH)D and the remaining sleep measures. Women in the high s-25(OH)D group had lower ESS-scores (−0.28 [-0.47, −0.08], p = .006), but higher odds of insomnia (1.16 [1.01, 1.33], p = .036) compared to women in the sufficient group. Conclusions: In this Arctic population, a tenuous association was found between s-25(OH)D and subjective sleep measures, predominantly in women. Article in Journal/Newspaper Arctic Arctic Population Tromsø Directory of Open Access Journals: DOAJ Articles Arctic Tromsø Sleep Medicine: X 4 100056 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Sleep duration Insomnia Excessive daytime sleepiness Vitamin D 25(OH)D Specialties of internal medicine RC581-951 |
spellingShingle |
Sleep duration Insomnia Excessive daytime sleepiness Vitamin D 25(OH)D Specialties of internal medicine RC581-951 A.U. Larsen L.A. Hopstock R. Jorde G. Grimnes Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
topic_facet |
Sleep duration Insomnia Excessive daytime sleepiness Vitamin D 25(OH)D Specialties of internal medicine RC581-951 |
description |
Objective: To investigate the relation between serum 25-hydroxyvitamin D (s-25(OH)D) and subjective sleep measures in an Arctic population (69°N). Methods: Cross-sectional data was collected from 21,083 individuals (aged ≥40 years) participating in the population based Tromsø Study: Tromsø7 (2015–2016). The present study included 20,438 participants, after having excluded respondents missing data on s-25(OH)D (n = 161) and/or subjective sleep measures (including sleep duration, insomnia, and daytime sleepiness)(n = 490). Based on s-25(OH)D (assessed using LC-MS/MS), participants were grouped as deficient (<30 nmol/L), insufficient (30–49.9 nmol/L), sufficient (50–75 nmol/L), or high (>75 nmol/L). Sleep duration was grouped as inadequate (ISD) if < 7 or ≥9 h. Linear and logistic regression were used to calculate unstandardized β-values and odds ratios [95% confidence intervals]. The analyses were adjusted for season, age, BMI, lifestyle factors and relevant comorbidities. Results: In both men and women, s-25(OH)D was positively associated with sleep duration, and compared to the sufficient s-25(OH)D group, the insufficient s-25(OH)D group reported significantly shorter sleep duration in both sexes. There was an increased odds of ISD in both men and women but adjusted for confounding factors this was only significant in women (1.16 [1.03, 1.32], p = .017). In men, there were no significant associations between s-25(OH)D and the remaining sleep measures. Women in the high s-25(OH)D group had lower ESS-scores (−0.28 [-0.47, −0.08], p = .006), but higher odds of insomnia (1.16 [1.01, 1.33], p = .036) compared to women in the sufficient group. Conclusions: In this Arctic population, a tenuous association was found between s-25(OH)D and subjective sleep measures, predominantly in women. |
format |
Article in Journal/Newspaper |
author |
A.U. Larsen L.A. Hopstock R. Jorde G. Grimnes |
author_facet |
A.U. Larsen L.A. Hopstock R. Jorde G. Grimnes |
author_sort |
A.U. Larsen |
title |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_short |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_full |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_fullStr |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_full_unstemmed |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_sort |
associations of serum 25-hydroxyvitamin d and subjective sleep measures in an arctic population: insights from the population-based tromsø study |
publisher |
Elsevier |
publishDate |
2022 |
url |
https://doi.org/10.1016/j.sleepx.2022.100056 https://doaj.org/article/c7bbe522c04646c4aeb12497a8709535 |
geographic |
Arctic Tromsø |
geographic_facet |
Arctic Tromsø |
genre |
Arctic Arctic Population Tromsø |
genre_facet |
Arctic Arctic Population Tromsø |
op_source |
Sleep Medicine: X, Vol 4, Iss , Pp 100056- (2022) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2590142722000155 https://doaj.org/toc/2590-1427 2590-1427 doi:10.1016/j.sleepx.2022.100056 https://doaj.org/article/c7bbe522c04646c4aeb12497a8709535 |
op_doi |
https://doi.org/10.1016/j.sleepx.2022.100056 |
container_title |
Sleep Medicine: X |
container_volume |
4 |
container_start_page |
100056 |
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1766328948231241728 |