L925I mutation in the Para-type sodium channel is associated with pyrethroid resistance in Triatoma infestans from the Gran Chaco region.

• Published in: PLoS Neglected Tropical Diseases
• Main Authors: Natalia Capriotti, Gastón Mougabure-Cueto, Rolando Rivera-Pomar, Sheila Ons
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2014
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Argentina; Chaco
• Online Access: https://doi.org/10.1371/journal.pntd.0002659; https://doaj.org/article/c7ab7f3b60df4a8492b3aaa3b53d2bc7

BACKGROUND: Chagas' disease is an important public health concern in Latin America. Despite intensive vector control efforts using pyrethroid insecticides, the elimination of Triatoma infestans has failed in the Gran Chaco, an ecoregion that extends over Argentina, Paraguay, Bolivia and Brazil....