Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS)
Semen quality may be adversely affected by exposure to environmental chemicals such as polychlorinated biphenyls (PCBs) and perfluorinated alkylate substances (PFASs) that are persistent and may act as endocrine disrupting compounds. The aim of this study was to explore whether PCBs or PFASs exposur...
Published in: | International Journal of Environmental Research and Public Health |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI AG
2018
|
Subjects: | |
Online Access: | https://doi.org/10.3390/ijerph15091880 https://doaj.org/article/c79fba3cc6144a7098dd42a42316aa7d |
id |
ftdoajarticles:oai:doaj.org/article:c79fba3cc6144a7098dd42a42316aa7d |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:c79fba3cc6144a7098dd42a42316aa7d 2023-05-15T16:10:52+02:00 Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) Maria Skaalum Petersen Jónrit Halling Niels Jørgensen Flemming Nielsen Philippe Grandjean Tina Kold Jensen Pál Weihe 2018-08-01T00:00:00Z https://doi.org/10.3390/ijerph15091880 https://doaj.org/article/c79fba3cc6144a7098dd42a42316aa7d EN eng MDPI AG http://www.mdpi.com/1660-4601/15/9/1880 https://doaj.org/toc/1660-4601 1660-4601 doi:10.3390/ijerph15091880 https://doaj.org/article/c79fba3cc6144a7098dd42a42316aa7d International Journal of Environmental Research and Public Health, Vol 15, Iss 9, p 1880 (2018) semen quality reproductive hormones endocrine disturbing compounds Faroe Islands Medicine R article 2018 ftdoajarticles https://doi.org/10.3390/ijerph15091880 2022-12-31T16:24:20Z Semen quality may be adversely affected by exposure to environmental chemicals such as polychlorinated biphenyls (PCBs) and perfluorinated alkylate substances (PFASs) that are persistent and may act as endocrine disrupting compounds. The aim of this study was to explore whether PCBs or PFASs exposure were associated with abnormalities in semen quality or reproductive hormones in Faroese men. This population based cross-sectional study includes 263 Faroese men (24–26 years) who delivered a semen sample for assessment of sperm concentration, total sperm count, semen volume, morphology and motility. A blood sample was drawn and analyzed for reproductive hormones, PCBs and PFASs. Exposure to ∑PCBs and perfluorooctane sulfonate (PFOS) was positively associated with sex hormone-binding globulin (SHBG) and luteinizing hormone (LH). In addition, total testosterone (T) was positively associated with ∑PCB. Both PCBs and PFOS appear to lead to increased SHBG, perhaps mediated via the liver. The higher total T associated with PCB may represent a compensatory adaption to elevated SHBG levels to maintain an unchanged free testosterone concentration. The positive association to LH for both PCBs and PFOS may indicate a direct adverse effect on the testosterone producing Leydig cells. Article in Journal/Newspaper Faroe Islands Directory of Open Access Journals: DOAJ Articles Faroe Islands International Journal of Environmental Research and Public Health 15 9 1880 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
semen quality reproductive hormones endocrine disturbing compounds Faroe Islands Medicine R |
spellingShingle |
semen quality reproductive hormones endocrine disturbing compounds Faroe Islands Medicine R Maria Skaalum Petersen Jónrit Halling Niels Jørgensen Flemming Nielsen Philippe Grandjean Tina Kold Jensen Pál Weihe Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) |
topic_facet |
semen quality reproductive hormones endocrine disturbing compounds Faroe Islands Medicine R |
description |
Semen quality may be adversely affected by exposure to environmental chemicals such as polychlorinated biphenyls (PCBs) and perfluorinated alkylate substances (PFASs) that are persistent and may act as endocrine disrupting compounds. The aim of this study was to explore whether PCBs or PFASs exposure were associated with abnormalities in semen quality or reproductive hormones in Faroese men. This population based cross-sectional study includes 263 Faroese men (24–26 years) who delivered a semen sample for assessment of sperm concentration, total sperm count, semen volume, morphology and motility. A blood sample was drawn and analyzed for reproductive hormones, PCBs and PFASs. Exposure to ∑PCBs and perfluorooctane sulfonate (PFOS) was positively associated with sex hormone-binding globulin (SHBG) and luteinizing hormone (LH). In addition, total testosterone (T) was positively associated with ∑PCB. Both PCBs and PFOS appear to lead to increased SHBG, perhaps mediated via the liver. The higher total T associated with PCB may represent a compensatory adaption to elevated SHBG levels to maintain an unchanged free testosterone concentration. The positive association to LH for both PCBs and PFOS may indicate a direct adverse effect on the testosterone producing Leydig cells. |
format |
Article in Journal/Newspaper |
author |
Maria Skaalum Petersen Jónrit Halling Niels Jørgensen Flemming Nielsen Philippe Grandjean Tina Kold Jensen Pál Weihe |
author_facet |
Maria Skaalum Petersen Jónrit Halling Niels Jørgensen Flemming Nielsen Philippe Grandjean Tina Kold Jensen Pál Weihe |
author_sort |
Maria Skaalum Petersen |
title |
Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) |
title_short |
Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) |
title_full |
Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) |
title_fullStr |
Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) |
title_full_unstemmed |
Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) |
title_sort |
reproductive function in a population of young faroese men with elevated exposure to polychlorinated biphenyls (pcbs) and perfluorinated alkylate substances (pfas) |
publisher |
MDPI AG |
publishDate |
2018 |
url |
https://doi.org/10.3390/ijerph15091880 https://doaj.org/article/c79fba3cc6144a7098dd42a42316aa7d |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
International Journal of Environmental Research and Public Health, Vol 15, Iss 9, p 1880 (2018) |
op_relation |
http://www.mdpi.com/1660-4601/15/9/1880 https://doaj.org/toc/1660-4601 1660-4601 doi:10.3390/ijerph15091880 https://doaj.org/article/c79fba3cc6144a7098dd42a42316aa7d |
op_doi |
https://doi.org/10.3390/ijerph15091880 |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
15 |
container_issue |
9 |
container_start_page |
1880 |
_version_ |
1765996008554102784 |