Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia
Introduction. Hematological alterations are frequent in malaria patients; the relationship between alterations in white blood cell counts and clinical status in malaria is not well understood. In Colombia, with low endemicity and unstable transmission for malaria, with malaria vivax predominance, th...
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ftdoajarticles:oai:doaj.org/article:c79d5940dfaa4b88baf7753134390f4c 2023-05-15T15:07:55+02:00 Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia Alberto Tobón-Castaño Esteban Mesa-Echeverry Andrés Felipe Miranda-Arboleda 2015-01-01T00:00:00Z https://doi.org/10.1155/2015/796182 https://doaj.org/article/c79d5940dfaa4b88baf7753134390f4c EN eng Hindawi Limited http://dx.doi.org/10.1155/2015/796182 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2015/796182 https://doaj.org/article/c79d5940dfaa4b88baf7753134390f4c Journal of Tropical Medicine, Vol 2015 (2015) Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.1155/2015/796182 2022-12-31T05:21:13Z Introduction. Hematological alterations are frequent in malaria patients; the relationship between alterations in white blood cell counts and clinical status in malaria is not well understood. In Colombia, with low endemicity and unstable transmission for malaria, with malaria vivax predominance, the hematologic profile in malaria patients is not well characterized. The aim of this study was to characterize the leukogram in malaria patients and to analyze its alterations in relation to the clinical status. Methods. 888 leukogram profiles of malaria patients from different Colombian regions were studied: 556 with P. falciparum infection (62.6%), 313 with P. vivax infection (35.2%), and 19 with mixed infection by these species (2.1%). Results. Leukocyte counts at diagnosis were within normal range in 79% of patients and 18% had leucopenia; the most frequent alteration was lymphopenia (54%) followed by monocytosis (11%); the differential granulocyte count in 298 patients revealed eosinophilia (15%) and high basophil counts (8%). Leukocytosis, eosinopenia, and neutrophilia were associated with clinical complications. The utility of changes in leukocyte counts as markers of severity should be explored in depth. A better understanding of these hematological parameters will allow their use in prompt diagnosis of malaria complications and monitoring treatment response. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2015 1 11 |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
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Arctic medicine. Tropical medicine RC955-962 Alberto Tobón-Castaño Esteban Mesa-Echeverry Andrés Felipe Miranda-Arboleda Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction. Hematological alterations are frequent in malaria patients; the relationship between alterations in white blood cell counts and clinical status in malaria is not well understood. In Colombia, with low endemicity and unstable transmission for malaria, with malaria vivax predominance, the hematologic profile in malaria patients is not well characterized. The aim of this study was to characterize the leukogram in malaria patients and to analyze its alterations in relation to the clinical status. Methods. 888 leukogram profiles of malaria patients from different Colombian regions were studied: 556 with P. falciparum infection (62.6%), 313 with P. vivax infection (35.2%), and 19 with mixed infection by these species (2.1%). Results. Leukocyte counts at diagnosis were within normal range in 79% of patients and 18% had leucopenia; the most frequent alteration was lymphopenia (54%) followed by monocytosis (11%); the differential granulocyte count in 298 patients revealed eosinophilia (15%) and high basophil counts (8%). Leukocytosis, eosinopenia, and neutrophilia were associated with clinical complications. The utility of changes in leukocyte counts as markers of severity should be explored in depth. A better understanding of these hematological parameters will allow their use in prompt diagnosis of malaria complications and monitoring treatment response. |
format |
Article in Journal/Newspaper |
author |
Alberto Tobón-Castaño Esteban Mesa-Echeverry Andrés Felipe Miranda-Arboleda |
author_facet |
Alberto Tobón-Castaño Esteban Mesa-Echeverry Andrés Felipe Miranda-Arboleda |
author_sort |
Alberto Tobón-Castaño |
title |
Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia |
title_short |
Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia |
title_full |
Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia |
title_fullStr |
Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia |
title_full_unstemmed |
Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia |
title_sort |
leukogram profile and clinical status in vivax and falciparum malaria patients from colombia |
publisher |
Hindawi Limited |
publishDate |
2015 |
url |
https://doi.org/10.1155/2015/796182 https://doaj.org/article/c79d5940dfaa4b88baf7753134390f4c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2015 (2015) |
op_relation |
http://dx.doi.org/10.1155/2015/796182 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2015/796182 https://doaj.org/article/c79d5940dfaa4b88baf7753134390f4c |
op_doi |
https://doi.org/10.1155/2015/796182 |
container_title |
Journal of Tropical Medicine |
container_volume |
2015 |
container_start_page |
1 |
op_container_end_page |
11 |
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1766339341669367808 |