Ebola virus disease: Recent advances in diagnostics and therapeutics
Ebola virus disease (EVD) is associated with haemorrhagic fever in humans and nonhuman primates, with a high rate of fatality (up to 90%). Some outbreaks in human history have proven the lethality of EVD. The recent epidemic of 2014 and 2015 in West Africa was the deadliest of all time (11 284 death...
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ftdoajarticles:oai:doaj.org/article:c79bd99fdd8f4ab0bb9c609279d2e33f 2023-05-15T15:07:31+02:00 Ebola virus disease: Recent advances in diagnostics and therapeutics Supriya Jagga Ashish Ranjan Sharma Chiranjib Chakraborty Sang-Soo Lee 2019-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.267581 https://doaj.org/article/c79bd99fdd8f4ab0bb9c609279d2e33f EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=9;spage=385;epage=395;aulast=Jagga https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.267581 https://doaj.org/article/c79bd99fdd8f4ab0bb9c609279d2e33f Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 9, Pp 385-395 (2019) ebola virus vaccines therapeutics ebola outbreaks diagnostics epidemiology haemorrhagic fever Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.4103/1995-7645.267581 2022-12-30T20:48:36Z Ebola virus disease (EVD) is associated with haemorrhagic fever in humans and nonhuman primates, with a high rate of fatality (up to 90%). Some outbreaks in human history have proven the lethality of EVD. The recent epidemic of 2014 and 2015 in West Africa was the deadliest of all time (11 284 deaths). To understand the transmission dynamics, we have reviewed the epidemiology of EVD to date. The absence of any licensed vaccines or approved drugs against Ebola virus (EBOV) further highlights the severity and crisis level of EVD. Some organizations (public and private) are making considerable efforts to develop novel therapeutic approaches or vaccines to contain the outbreak of EBOV shortly. Here, we summarized the various potential drugs and vaccines (undergoing multiple phases of clinical trials) that have arisen as an alternative against EBOV, and we highlighted the numerous issues and limitations hindering this process. Alternatively, an increasing focus on strengthening the medical and civic health structure could provide speedy benefits in containing the spread of EVD, as well as offer a resilient foundation for the deployment of novel drugs and vaccines to the affected countries, once such drugs and vaccines become available. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 12 9 385 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
ebola virus vaccines therapeutics ebola outbreaks diagnostics epidemiology haemorrhagic fever Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
ebola virus vaccines therapeutics ebola outbreaks diagnostics epidemiology haemorrhagic fever Arctic medicine. Tropical medicine RC955-962 Supriya Jagga Ashish Ranjan Sharma Chiranjib Chakraborty Sang-Soo Lee Ebola virus disease: Recent advances in diagnostics and therapeutics |
topic_facet |
ebola virus vaccines therapeutics ebola outbreaks diagnostics epidemiology haemorrhagic fever Arctic medicine. Tropical medicine RC955-962 |
description |
Ebola virus disease (EVD) is associated with haemorrhagic fever in humans and nonhuman primates, with a high rate of fatality (up to 90%). Some outbreaks in human history have proven the lethality of EVD. The recent epidemic of 2014 and 2015 in West Africa was the deadliest of all time (11 284 deaths). To understand the transmission dynamics, we have reviewed the epidemiology of EVD to date. The absence of any licensed vaccines or approved drugs against Ebola virus (EBOV) further highlights the severity and crisis level of EVD. Some organizations (public and private) are making considerable efforts to develop novel therapeutic approaches or vaccines to contain the outbreak of EBOV shortly. Here, we summarized the various potential drugs and vaccines (undergoing multiple phases of clinical trials) that have arisen as an alternative against EBOV, and we highlighted the numerous issues and limitations hindering this process. Alternatively, an increasing focus on strengthening the medical and civic health structure could provide speedy benefits in containing the spread of EVD, as well as offer a resilient foundation for the deployment of novel drugs and vaccines to the affected countries, once such drugs and vaccines become available. |
format |
Article in Journal/Newspaper |
author |
Supriya Jagga Ashish Ranjan Sharma Chiranjib Chakraborty Sang-Soo Lee |
author_facet |
Supriya Jagga Ashish Ranjan Sharma Chiranjib Chakraborty Sang-Soo Lee |
author_sort |
Supriya Jagga |
title |
Ebola virus disease: Recent advances in diagnostics and therapeutics |
title_short |
Ebola virus disease: Recent advances in diagnostics and therapeutics |
title_full |
Ebola virus disease: Recent advances in diagnostics and therapeutics |
title_fullStr |
Ebola virus disease: Recent advances in diagnostics and therapeutics |
title_full_unstemmed |
Ebola virus disease: Recent advances in diagnostics and therapeutics |
title_sort |
ebola virus disease: recent advances in diagnostics and therapeutics |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2019 |
url |
https://doi.org/10.4103/1995-7645.267581 https://doaj.org/article/c79bd99fdd8f4ab0bb9c609279d2e33f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 9, Pp 385-395 (2019) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=9;spage=385;epage=395;aulast=Jagga https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.267581 https://doaj.org/article/c79bd99fdd8f4ab0bb9c609279d2e33f |
op_doi |
https://doi.org/10.4103/1995-7645.267581 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
12 |
container_issue |
9 |
container_start_page |
385 |
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