Validation study of HLA-B*13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Hana Krismawati, Astrid Irwanto, Arry Pongtiku, Ishak Darryl Irwan, Yustinus Maladan, Yuli Arisanti Sitanggang, Tri Wahyuni, Ratna Tanjung, Yonghu Sun, Hong Liu, Furen Zhang, Antonius Oktavian, Jianjun Liu
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2020
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Papua Island
• Online Access: https://doi.org/10.1371/journal.pntd.0008746; https://doaj.org/article/c783291113b74b05aa9da407139ec057

Leprosy is a stigmatizing, chronic infection which degenerates the nervous system and often leads to incapacitation. Multi-drug therapy which consists of dapsone, rifampicin and clofazimine has been effective to combat this disease. In Indonesia, especially in Papua Island, leprosy is still a proble...