Access to benznidazole for Chagas disease in the United States-Cautious optimism?
Drugs for neglected tropical diseases (NTD) are being excessively priced in the United States. Benznidazole, the first-line drug for Chagas disease, may become approved by the Food and Drug Administration (FDA) and manufactured by a private company in the US, thus placing it at risk of similar prici...
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ftdoajarticles:oai:doaj.org/article:c7424dceaa3f46a1b298ff3a5352fbe4 2023-05-15T15:07:15+02:00 Access to benznidazole for Chagas disease in the United States-Cautious optimism? Jonathan D Alpern Rogelio Lopez-Velez William M Stauffer 2017-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005794 https://doaj.org/article/c7424dceaa3f46a1b298ff3a5352fbe4 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5598921?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005794 https://doaj.org/article/c7424dceaa3f46a1b298ff3a5352fbe4 PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005794 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005794 2023-01-08T01:27:25Z Drugs for neglected tropical diseases (NTD) are being excessively priced in the United States. Benznidazole, the first-line drug for Chagas disease, may become approved by the Food and Drug Administration (FDA) and manufactured by a private company in the US, thus placing it at risk of similar pricing. Chagas disease is an NTD caused by Trypanosoma cruzi; it is endemic to Latin America, infecting 8 million individuals. Human migration has changed the epidemiology causing nonendemic countries to face increased challenges in diagnosing and managing patients with Chagas disease. Only 2 drugs exist with proven efficacy: benznidazole and nifurtimox. Benznidazole has historically faced supply problems and drug shortages, limiting accessibility. In the US, it is currently only available under an investigational new drug (IND) protocol from the CDC and is provided free of charge to patients. However, 2 companies have stated that they intend to submit a New Drug Application (NDA) for FDA approval. Based on recent history of companies acquiring licensing rights for NTD drugs in the US with limited availability, it is likely that benznidazole will become excessively priced by the manufacturer-paradoxically making it less accessible. However, if the companies can be taken at their word, there may be reason for optimism. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 9 e0005794 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jonathan D Alpern Rogelio Lopez-Velez William M Stauffer Access to benznidazole for Chagas disease in the United States-Cautious optimism? |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Drugs for neglected tropical diseases (NTD) are being excessively priced in the United States. Benznidazole, the first-line drug for Chagas disease, may become approved by the Food and Drug Administration (FDA) and manufactured by a private company in the US, thus placing it at risk of similar pricing. Chagas disease is an NTD caused by Trypanosoma cruzi; it is endemic to Latin America, infecting 8 million individuals. Human migration has changed the epidemiology causing nonendemic countries to face increased challenges in diagnosing and managing patients with Chagas disease. Only 2 drugs exist with proven efficacy: benznidazole and nifurtimox. Benznidazole has historically faced supply problems and drug shortages, limiting accessibility. In the US, it is currently only available under an investigational new drug (IND) protocol from the CDC and is provided free of charge to patients. However, 2 companies have stated that they intend to submit a New Drug Application (NDA) for FDA approval. Based on recent history of companies acquiring licensing rights for NTD drugs in the US with limited availability, it is likely that benznidazole will become excessively priced by the manufacturer-paradoxically making it less accessible. However, if the companies can be taken at their word, there may be reason for optimism. |
format |
Article in Journal/Newspaper |
author |
Jonathan D Alpern Rogelio Lopez-Velez William M Stauffer |
author_facet |
Jonathan D Alpern Rogelio Lopez-Velez William M Stauffer |
author_sort |
Jonathan D Alpern |
title |
Access to benznidazole for Chagas disease in the United States-Cautious optimism? |
title_short |
Access to benznidazole for Chagas disease in the United States-Cautious optimism? |
title_full |
Access to benznidazole for Chagas disease in the United States-Cautious optimism? |
title_fullStr |
Access to benznidazole for Chagas disease in the United States-Cautious optimism? |
title_full_unstemmed |
Access to benznidazole for Chagas disease in the United States-Cautious optimism? |
title_sort |
access to benznidazole for chagas disease in the united states-cautious optimism? |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005794 https://doaj.org/article/c7424dceaa3f46a1b298ff3a5352fbe4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005794 (2017) |
op_relation |
http://europepmc.org/articles/PMC5598921?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005794 https://doaj.org/article/c7424dceaa3f46a1b298ff3a5352fbe4 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005794 |
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PLOS Neglected Tropical Diseases |
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11 |
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9 |
container_start_page |
e0005794 |
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