Cell migration induced by Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) major and Leishmania (Viannia) braziliensis into the peritoneal cavity of BALB/c mice
In American cutaneous leishmaniasis, the initial infection phase is characterized by recruitment of neutrophils and monocytes. The migration of these cells in response to the presence of Leishmania in the peritoneum of affected animals remains unclear. The objective of this study was to investigate...
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ftdoajarticles:oai:doaj.org/article:c73e654783cc4d15bb374f61745e355f 2023-05-15T15:07:45+02:00 Cell migration induced by Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) major and Leishmania (Viannia) braziliensis into the peritoneal cavity of BALB/c mice DT Wakimoto KV Gaspareto TGV Silveira MVC Lonardoni SMA Aristides 2010-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992010000100017 https://doaj.org/article/c73e654783cc4d15bb374f61745e355f EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000100017 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992010000100017 1678-9199 https://doaj.org/article/c73e654783cc4d15bb374f61745e355f Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 16, Iss 1, Pp 170-177 (2010) BALB/c mice Leishmania spp American cutaneous leishmaniasis Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2010 ftdoajarticles https://doi.org/10.1590/S1678-91992010000100017 2022-12-31T16:03:14Z In American cutaneous leishmaniasis, the initial infection phase is characterized by recruitment of neutrophils and monocytes. The migration of these cells in response to the presence of Leishmania in the peritoneum of affected animals remains unclear. The objective of this study was to investigate cell migration to the peritoneum of BALB/c mice after infection with Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis and Leishmania (Leishmania) major. Initially, Leishmania spp. was intraperitoneally inoculated in five groups of six animals each and the cell migration was analyzed 0, 3, 6, 12, 24 and 48 hours after infection. Different cell counts were performed with a staining kit and showed a higher percentage of polymorphonuclear than mononuclear cells in all three species studied. The total cell count revealed peak migration in L. (L.) amazonensis and L. (L.) major at six hours, and in L. (V.) braziliensis at 12 hours. These results suggest that factors released from different cell types probably act by attracting polymorphonuclear cells, with the peak migration most likely depending on the species of Leishmania inoculated into the host. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 16 1 170 177 |
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Directory of Open Access Journals: DOAJ Articles |
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BALB/c mice Leishmania spp American cutaneous leishmaniasis Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
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BALB/c mice Leishmania spp American cutaneous leishmaniasis Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 DT Wakimoto KV Gaspareto TGV Silveira MVC Lonardoni SMA Aristides Cell migration induced by Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) major and Leishmania (Viannia) braziliensis into the peritoneal cavity of BALB/c mice |
topic_facet |
BALB/c mice Leishmania spp American cutaneous leishmaniasis Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
In American cutaneous leishmaniasis, the initial infection phase is characterized by recruitment of neutrophils and monocytes. The migration of these cells in response to the presence of Leishmania in the peritoneum of affected animals remains unclear. The objective of this study was to investigate cell migration to the peritoneum of BALB/c mice after infection with Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis and Leishmania (Leishmania) major. Initially, Leishmania spp. was intraperitoneally inoculated in five groups of six animals each and the cell migration was analyzed 0, 3, 6, 12, 24 and 48 hours after infection. Different cell counts were performed with a staining kit and showed a higher percentage of polymorphonuclear than mononuclear cells in all three species studied. The total cell count revealed peak migration in L. (L.) amazonensis and L. (L.) major at six hours, and in L. (V.) braziliensis at 12 hours. These results suggest that factors released from different cell types probably act by attracting polymorphonuclear cells, with the peak migration most likely depending on the species of Leishmania inoculated into the host. |
format |
Article in Journal/Newspaper |
author |
DT Wakimoto KV Gaspareto TGV Silveira MVC Lonardoni SMA Aristides |
author_facet |
DT Wakimoto KV Gaspareto TGV Silveira MVC Lonardoni SMA Aristides |
author_sort |
DT Wakimoto |
title |
Cell migration induced by Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) major and Leishmania (Viannia) braziliensis into the peritoneal cavity of BALB/c mice |
title_short |
Cell migration induced by Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) major and Leishmania (Viannia) braziliensis into the peritoneal cavity of BALB/c mice |
title_full |
Cell migration induced by Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) major and Leishmania (Viannia) braziliensis into the peritoneal cavity of BALB/c mice |
title_fullStr |
Cell migration induced by Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) major and Leishmania (Viannia) braziliensis into the peritoneal cavity of BALB/c mice |
title_full_unstemmed |
Cell migration induced by Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) major and Leishmania (Viannia) braziliensis into the peritoneal cavity of BALB/c mice |
title_sort |
cell migration induced by leishmania (leishmania) amazonensis, leishmania (leishmania) major and leishmania (viannia) braziliensis into the peritoneal cavity of balb/c mice |
publisher |
SciELO |
publishDate |
2010 |
url |
https://doi.org/10.1590/S1678-91992010000100017 https://doaj.org/article/c73e654783cc4d15bb374f61745e355f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 16, Iss 1, Pp 170-177 (2010) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000100017 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992010000100017 1678-9199 https://doaj.org/article/c73e654783cc4d15bb374f61745e355f |
op_doi |
https://doi.org/10.1590/S1678-91992010000100017 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
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16 |
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170 |
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177 |
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