Voacanga grandifolia (Miq.) Rolfe protects against alcohol-induced liver toxicity in rats
Objective: To evaluate the ethanol extract of Voacanga grandifolia for hepatoprotective and antioxidant potential against ethanolinduced liver toxicity in rats. Methods: Sprague-Dawley rats were administered ethanol (7 g/kg) and then treated with 100 and 200 mg/kg of Voacanga grandifolia extract. Th...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2022
|
Subjects: | |
Online Access: | https://doi.org/10.4103/2221-1691.363876 https://doaj.org/article/c737b5fa8dc449198320e282f7addd71 |
id |
ftdoajarticles:oai:doaj.org/article:c737b5fa8dc449198320e282f7addd71 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:c737b5fa8dc449198320e282f7addd71 2023-05-15T15:06:58+02:00 Voacanga grandifolia (Miq.) Rolfe protects against alcohol-induced liver toxicity in rats Lal Chand Pal Shivankar Agrawal Arti Gautam 2022-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.363876 https://doaj.org/article/c737b5fa8dc449198320e282f7addd71 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=12;spage=504;epage=511;aulast=Pal https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.363876 https://doaj.org/article/c737b5fa8dc449198320e282f7addd71 Asian Pacific Journal of Tropical Biomedicine, Vol 12, Iss 12, Pp 504-511 (2022) antioxidant ethanol-induced toxicity hepatoprotective hepatic markers voacanga grandifolia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2022 ftdoajarticles https://doi.org/10.4103/2221-1691.363876 2023-01-15T01:25:47Z Objective: To evaluate the ethanol extract of Voacanga grandifolia for hepatoprotective and antioxidant potential against ethanolinduced liver toxicity in rats. Methods: Sprague-Dawley rats were administered ethanol (7 g/kg) and then treated with 100 and 200 mg/kg of Voacanga grandifolia extract. The phytochemical constituents and antioxidant potential of Voacanga grandifolia extract were evaluated by GC-MS and in vitro antioxidant assays. Biochemical indicators for liver damage and proapoptotic and antiapoptotic gene expression were determined using biochemical kits, ELISA, and qRT-PCR, respectively. Additionally, histopathological study of the liver was performed. Results: GC-MS identified propanoic acid, meso-erythritol, D-pinitol, myo-inositol, and hexadecanoic acid in Voacanga grandifolia extract. Voacanga grandifolia extract (100 and 200 mg/kg) increased the concentration of enzymatic antioxidants while diminishing the levels of inflammatory cytokines and biochemical indicators. qRT-PCR assay showed that Voacanga grandifolia extracts upregulated antiapoptotic gene expression while downregulating pro-apoptotic gene expression. Furthermore, the plant extract improved the hepatic architecture of ethanol-intoxicated rats. Conclusions: Voacanga grandifolia extract demonstrates hepatoprotective activity against alcohol-induced liver injury in rats and could be a potential hepatoprotective agent. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 12 12 504 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
antioxidant ethanol-induced toxicity hepatoprotective hepatic markers voacanga grandifolia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
antioxidant ethanol-induced toxicity hepatoprotective hepatic markers voacanga grandifolia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Lal Chand Pal Shivankar Agrawal Arti Gautam Voacanga grandifolia (Miq.) Rolfe protects against alcohol-induced liver toxicity in rats |
topic_facet |
antioxidant ethanol-induced toxicity hepatoprotective hepatic markers voacanga grandifolia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the ethanol extract of Voacanga grandifolia for hepatoprotective and antioxidant potential against ethanolinduced liver toxicity in rats. Methods: Sprague-Dawley rats were administered ethanol (7 g/kg) and then treated with 100 and 200 mg/kg of Voacanga grandifolia extract. The phytochemical constituents and antioxidant potential of Voacanga grandifolia extract were evaluated by GC-MS and in vitro antioxidant assays. Biochemical indicators for liver damage and proapoptotic and antiapoptotic gene expression were determined using biochemical kits, ELISA, and qRT-PCR, respectively. Additionally, histopathological study of the liver was performed. Results: GC-MS identified propanoic acid, meso-erythritol, D-pinitol, myo-inositol, and hexadecanoic acid in Voacanga grandifolia extract. Voacanga grandifolia extract (100 and 200 mg/kg) increased the concentration of enzymatic antioxidants while diminishing the levels of inflammatory cytokines and biochemical indicators. qRT-PCR assay showed that Voacanga grandifolia extracts upregulated antiapoptotic gene expression while downregulating pro-apoptotic gene expression. Furthermore, the plant extract improved the hepatic architecture of ethanol-intoxicated rats. Conclusions: Voacanga grandifolia extract demonstrates hepatoprotective activity against alcohol-induced liver injury in rats and could be a potential hepatoprotective agent. |
format |
Article in Journal/Newspaper |
author |
Lal Chand Pal Shivankar Agrawal Arti Gautam |
author_facet |
Lal Chand Pal Shivankar Agrawal Arti Gautam |
author_sort |
Lal Chand Pal |
title |
Voacanga grandifolia (Miq.) Rolfe protects against alcohol-induced liver toxicity in rats |
title_short |
Voacanga grandifolia (Miq.) Rolfe protects against alcohol-induced liver toxicity in rats |
title_full |
Voacanga grandifolia (Miq.) Rolfe protects against alcohol-induced liver toxicity in rats |
title_fullStr |
Voacanga grandifolia (Miq.) Rolfe protects against alcohol-induced liver toxicity in rats |
title_full_unstemmed |
Voacanga grandifolia (Miq.) Rolfe protects against alcohol-induced liver toxicity in rats |
title_sort |
voacanga grandifolia (miq.) rolfe protects against alcohol-induced liver toxicity in rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2022 |
url |
https://doi.org/10.4103/2221-1691.363876 https://doaj.org/article/c737b5fa8dc449198320e282f7addd71 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 12, Iss 12, Pp 504-511 (2022) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=12;spage=504;epage=511;aulast=Pal https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.363876 https://doaj.org/article/c737b5fa8dc449198320e282f7addd71 |
op_doi |
https://doi.org/10.4103/2221-1691.363876 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
12 |
container_issue |
12 |
container_start_page |
504 |
_version_ |
1766338546438766592 |