Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans
Background. The Indigenous Arctic population is of Asian descent, and their genetic background is different from the Caucasian populations. Relatively little is known about the specific genetic polymorphisms in genes involved in the activation and detoxification mechanisms of environmental contamina...
Published in: | International Journal of Circumpolar Health |
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2013
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Online Access: | https://doi.org/10.3402/ijch.v72i0.21113 https://doaj.org/article/c6db2a8041ff4b38b116271d5c497d57 |
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ftdoajarticles:oai:doaj.org/article:c6db2a8041ff4b38b116271d5c497d57 2023-05-15T15:00:01+02:00 Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans Mandana Ghisari Manhai Long Eva C. Bonefeld-Jørgensen 2013-06-01T00:00:00Z https://doi.org/10.3402/ijch.v72i0.21113 https://doaj.org/article/c6db2a8041ff4b38b116271d5c497d57 EN eng Taylor & Francis Group www.circumpolarhealthjournal.net/index.php/ijch/article/download/21113/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v72i0.21113 2242-3982 https://doaj.org/article/c6db2a8041ff4b38b116271d5c497d57 International Journal of Circumpolar Health, Vol 72, Iss 0, Pp 1-9 (2013) Inuit genetic polymorphism cytochrome P450 COMT persistent organic pollutants PCBs Arctic medicine. Tropical medicine RC955-962 article 2013 ftdoajarticles https://doi.org/10.3402/ijch.v72i0.21113 2022-12-31T01:38:01Z Background. The Indigenous Arctic population is of Asian descent, and their genetic background is different from the Caucasian populations. Relatively little is known about the specific genetic polymorphisms in genes involved in the activation and detoxification mechanisms of environmental contaminants in Inuit and its relation to health risk. The Greenlandic Inuit are highly exposed to legacy persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs), and an elucidation of gene–environment interactions in relation to health risks is needed. Objectives. The aim of this study was to determine and compare the genotype and allele frequencies of the cytochrome P450 CYP1A1 Ile462Val (rs1048943), CYP1B1 Leu432Val (rs1056836) and catechol-O-methyltransferase COMT Val158Met (rs4680) in Greenlandic Inuit (n=254) and Europeans (n=262) and explore the possible relation between the genotypes and serum levels of POPs. Results. The genotype and allele frequency distributions of the three genetic polymorphisms differed significantly between the Inuit and Europeans. For Inuit, the genotype distribution was more similar to those reported for Asian populations. We observed a significant difference in serum polychlorinated biphenyl (CB-153) and the pesticide 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p′-DDE) levels between Inuit and Europeans, and for Inuit also associations between the POP levels and genotypes for CYP1A1, CYP1B1 and COMT. Conclusion. Our data provide new information on gene polymorphisms in Greenlandic Inuit that might support evaluation of susceptibility to environmental contaminants and warrant further studies. Article in Journal/Newspaper Arctic Arctic Population Circumpolar Health greenlandic International Journal of Circumpolar Health inuit Directory of Open Access Journals: DOAJ Articles Arctic International Journal of Circumpolar Health 72 1 21113 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Inuit genetic polymorphism cytochrome P450 COMT persistent organic pollutants PCBs Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Inuit genetic polymorphism cytochrome P450 COMT persistent organic pollutants PCBs Arctic medicine. Tropical medicine RC955-962 Mandana Ghisari Manhai Long Eva C. Bonefeld-Jørgensen Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans |
topic_facet |
Inuit genetic polymorphism cytochrome P450 COMT persistent organic pollutants PCBs Arctic medicine. Tropical medicine RC955-962 |
description |
Background. The Indigenous Arctic population is of Asian descent, and their genetic background is different from the Caucasian populations. Relatively little is known about the specific genetic polymorphisms in genes involved in the activation and detoxification mechanisms of environmental contaminants in Inuit and its relation to health risk. The Greenlandic Inuit are highly exposed to legacy persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs), and an elucidation of gene–environment interactions in relation to health risks is needed. Objectives. The aim of this study was to determine and compare the genotype and allele frequencies of the cytochrome P450 CYP1A1 Ile462Val (rs1048943), CYP1B1 Leu432Val (rs1056836) and catechol-O-methyltransferase COMT Val158Met (rs4680) in Greenlandic Inuit (n=254) and Europeans (n=262) and explore the possible relation between the genotypes and serum levels of POPs. Results. The genotype and allele frequency distributions of the three genetic polymorphisms differed significantly between the Inuit and Europeans. For Inuit, the genotype distribution was more similar to those reported for Asian populations. We observed a significant difference in serum polychlorinated biphenyl (CB-153) and the pesticide 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p′-DDE) levels between Inuit and Europeans, and for Inuit also associations between the POP levels and genotypes for CYP1A1, CYP1B1 and COMT. Conclusion. Our data provide new information on gene polymorphisms in Greenlandic Inuit that might support evaluation of susceptibility to environmental contaminants and warrant further studies. |
format |
Article in Journal/Newspaper |
author |
Mandana Ghisari Manhai Long Eva C. Bonefeld-Jørgensen |
author_facet |
Mandana Ghisari Manhai Long Eva C. Bonefeld-Jørgensen |
author_sort |
Mandana Ghisari |
title |
Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans |
title_short |
Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans |
title_full |
Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans |
title_fullStr |
Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans |
title_full_unstemmed |
Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans |
title_sort |
genetic polymorphisms in cyp1a1, cyp1b1 and comt genes in greenlandic inuit and europeans |
publisher |
Taylor & Francis Group |
publishDate |
2013 |
url |
https://doi.org/10.3402/ijch.v72i0.21113 https://doaj.org/article/c6db2a8041ff4b38b116271d5c497d57 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Arctic Population Circumpolar Health greenlandic International Journal of Circumpolar Health inuit |
genre_facet |
Arctic Arctic Population Circumpolar Health greenlandic International Journal of Circumpolar Health inuit |
op_source |
International Journal of Circumpolar Health, Vol 72, Iss 0, Pp 1-9 (2013) |
op_relation |
www.circumpolarhealthjournal.net/index.php/ijch/article/download/21113/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v72i0.21113 2242-3982 https://doaj.org/article/c6db2a8041ff4b38b116271d5c497d57 |
op_doi |
https://doi.org/10.3402/ijch.v72i0.21113 |
container_title |
International Journal of Circumpolar Health |
container_volume |
72 |
container_issue |
1 |
container_start_page |
21113 |
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1766332125531865088 |