Autoimmune Hepatitis in a North American Aboriginal/First Nations Population
North American Aboriginal populations are at increased risk for developing immune-mediated disorders, including autoimmune hepatitis. In the present study, the demographic, clinical, biochemical, serological, radiological and histological features of autoimmune hepatitis were compared in 33 First Na...
Published in: | Canadian Journal of Gastroenterology |
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ftdoajarticles:oai:doaj.org/article:c6c33d99dd86474c804a7f8687f311c7 2024-09-15T18:06:33+00:00 Autoimmune Hepatitis in a North American Aboriginal/First Nations Population GY Minuk S Liu K Kaita S Wong E Renner J Rempel J Uhanova 2008-01-01T00:00:00Z https://doi.org/10.1155/2008/642432 https://doaj.org/article/c6c33d99dd86474c804a7f8687f311c7 EN eng Wiley http://dx.doi.org/10.1155/2008/642432 https://doaj.org/toc/0835-7900 0835-7900 doi:10.1155/2008/642432 https://doaj.org/article/c6c33d99dd86474c804a7f8687f311c7 Canadian Journal of Gastroenterology, Vol 22, Iss 10, Pp 829-834 (2008) Diseases of the digestive system. Gastroenterology RC799-869 article 2008 ftdoajarticles https://doi.org/10.1155/2008/642432 2024-08-05T17:48:38Z North American Aboriginal populations are at increased risk for developing immune-mediated disorders, including autoimmune hepatitis. In the present study, the demographic, clinical, biochemical, serological, radiological and histological features of autoimmune hepatitis were compared in 33 First Nations (FN) and 150 predominantly Caucasian, non-FN patients referred to an urban tertiary care centre. FN patients were more often female (91% versus 71%; P=0.04), and more likely to have low serum albumin (69% versus 36%; P=0.0006) and elevated bilirubin (57% versus 35%; P=0.01) levels on presentation compared with non-FN patients. They also had lower hemoglobin, and complement levels, more cholestasis and higher serum immunoglobulin A levels than non-FN patients (P=0.05 respectively). Higher histological grades of inflammation and stages of fibrosis, and more clinical and radiological evidence of advanced liver disease were observed in FN patients, but the differences failed to reach statistical significance. The results of the present study suggest that in addition to being more common, autoimmune hepatitis may be more severe in FN populations, compared with predominantly Caucasian, non-FN populations. Article in Journal/Newspaper First Nations Directory of Open Access Journals: DOAJ Articles Canadian Journal of Gastroenterology 22 10 829 834 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Diseases of the digestive system. Gastroenterology RC799-869 |
spellingShingle |
Diseases of the digestive system. Gastroenterology RC799-869 GY Minuk S Liu K Kaita S Wong E Renner J Rempel J Uhanova Autoimmune Hepatitis in a North American Aboriginal/First Nations Population |
topic_facet |
Diseases of the digestive system. Gastroenterology RC799-869 |
description |
North American Aboriginal populations are at increased risk for developing immune-mediated disorders, including autoimmune hepatitis. In the present study, the demographic, clinical, biochemical, serological, radiological and histological features of autoimmune hepatitis were compared in 33 First Nations (FN) and 150 predominantly Caucasian, non-FN patients referred to an urban tertiary care centre. FN patients were more often female (91% versus 71%; P=0.04), and more likely to have low serum albumin (69% versus 36%; P=0.0006) and elevated bilirubin (57% versus 35%; P=0.01) levels on presentation compared with non-FN patients. They also had lower hemoglobin, and complement levels, more cholestasis and higher serum immunoglobulin A levels than non-FN patients (P=0.05 respectively). Higher histological grades of inflammation and stages of fibrosis, and more clinical and radiological evidence of advanced liver disease were observed in FN patients, but the differences failed to reach statistical significance. The results of the present study suggest that in addition to being more common, autoimmune hepatitis may be more severe in FN populations, compared with predominantly Caucasian, non-FN populations. |
format |
Article in Journal/Newspaper |
author |
GY Minuk S Liu K Kaita S Wong E Renner J Rempel J Uhanova |
author_facet |
GY Minuk S Liu K Kaita S Wong E Renner J Rempel J Uhanova |
author_sort |
GY Minuk |
title |
Autoimmune Hepatitis in a North American Aboriginal/First Nations Population |
title_short |
Autoimmune Hepatitis in a North American Aboriginal/First Nations Population |
title_full |
Autoimmune Hepatitis in a North American Aboriginal/First Nations Population |
title_fullStr |
Autoimmune Hepatitis in a North American Aboriginal/First Nations Population |
title_full_unstemmed |
Autoimmune Hepatitis in a North American Aboriginal/First Nations Population |
title_sort |
autoimmune hepatitis in a north american aboriginal/first nations population |
publisher |
Wiley |
publishDate |
2008 |
url |
https://doi.org/10.1155/2008/642432 https://doaj.org/article/c6c33d99dd86474c804a7f8687f311c7 |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Canadian Journal of Gastroenterology, Vol 22, Iss 10, Pp 829-834 (2008) |
op_relation |
http://dx.doi.org/10.1155/2008/642432 https://doaj.org/toc/0835-7900 0835-7900 doi:10.1155/2008/642432 https://doaj.org/article/c6c33d99dd86474c804a7f8687f311c7 |
op_doi |
https://doi.org/10.1155/2008/642432 |
container_title |
Canadian Journal of Gastroenterology |
container_volume |
22 |
container_issue |
10 |
container_start_page |
829 |
op_container_end_page |
834 |
_version_ |
1810443972943806464 |