Fluconazole as a therapeutic alternative in infections associated with Mycobacterium tuberculosis
Mycobacterium tuberculosis (M. tuberculosis) is a microorganism whose importance as an infectious agent has remained over the years but which has become a recent emergency and a serious public health problem in response to the evolution in its behavior against first-line antimicrobials, for its trea...
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Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales
2018
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ftdoajarticles:oai:doaj.org/article:c6c0467688024fc39698d54eef416aec 2023-10-09T21:49:08+02:00 Fluconazole as a therapeutic alternative in infections associated with Mycobacterium tuberculosis Lisette Sandrea Cesar Ramirez Zolay Romay 2018-06-01T00:00:00Z https://doaj.org/article/c6c0467688024fc39698d54eef416aec EN ES eng spa Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales https://produccioncientificaluz.org/index.php/kasmera/article/view/24657 https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/c6c0467688024fc39698d54eef416aec Kasmera, Vol 46, Iss 1, Pp 61-69 (2018) Pruebas de sensibilidad microbiana fluconazol Mycobacterium tuberculosis rifampicina isoniazida Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles 2023-09-10T00:48:45Z Mycobacterium tuberculosis (M. tuberculosis) is a microorganism whose importance as an infectious agent has remained over the years but which has become a recent emergency and a serious public health problem in response to the evolution in its behavior against first-line antimicrobials, for its treatment and the emergence of multi-resistant strains, which require the use of therapeutic alternatives that allow its control. The objective of the work was to evaluate the in vitro behavior of M. tuberculosis before the antifungal agent fluconazole, for its possible use as a therapeutic alternative. To this, six strains were evaluated M. tuberculosis: 2 resistants to rifampicin, 2 resistants to isoniazid and 2 sensitive to both antimicrobials. We used the method of Minimum Inhibitory Concentration, using the microplate technique with Alamar Blue and the tube technique. Both methodologies showed sensitivity to low concentrations of fluconazole (0.0625 μg/ml). All strains were sensitive to the fluconazole / isoniazid combination; whereas, when exposed to the fluconazole / rifampicin combination, the strains showed resistance, indicating the antagonistic effect of rifampicin on fluconazole. The results allow us to conclude and suggest the possible therapeutic use of fluconazole against infections associated with M. tuberculosis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English Spanish |
topic |
Pruebas de sensibilidad microbiana fluconazol Mycobacterium tuberculosis rifampicina isoniazida Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Pruebas de sensibilidad microbiana fluconazol Mycobacterium tuberculosis rifampicina isoniazida Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Lisette Sandrea Cesar Ramirez Zolay Romay Fluconazole as a therapeutic alternative in infections associated with Mycobacterium tuberculosis |
topic_facet |
Pruebas de sensibilidad microbiana fluconazol Mycobacterium tuberculosis rifampicina isoniazida Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Mycobacterium tuberculosis (M. tuberculosis) is a microorganism whose importance as an infectious agent has remained over the years but which has become a recent emergency and a serious public health problem in response to the evolution in its behavior against first-line antimicrobials, for its treatment and the emergence of multi-resistant strains, which require the use of therapeutic alternatives that allow its control. The objective of the work was to evaluate the in vitro behavior of M. tuberculosis before the antifungal agent fluconazole, for its possible use as a therapeutic alternative. To this, six strains were evaluated M. tuberculosis: 2 resistants to rifampicin, 2 resistants to isoniazid and 2 sensitive to both antimicrobials. We used the method of Minimum Inhibitory Concentration, using the microplate technique with Alamar Blue and the tube technique. Both methodologies showed sensitivity to low concentrations of fluconazole (0.0625 μg/ml). All strains were sensitive to the fluconazole / isoniazid combination; whereas, when exposed to the fluconazole / rifampicin combination, the strains showed resistance, indicating the antagonistic effect of rifampicin on fluconazole. The results allow us to conclude and suggest the possible therapeutic use of fluconazole against infections associated with M. tuberculosis. |
format |
Article in Journal/Newspaper |
author |
Lisette Sandrea Cesar Ramirez Zolay Romay |
author_facet |
Lisette Sandrea Cesar Ramirez Zolay Romay |
author_sort |
Lisette Sandrea |
title |
Fluconazole as a therapeutic alternative in infections associated with Mycobacterium tuberculosis |
title_short |
Fluconazole as a therapeutic alternative in infections associated with Mycobacterium tuberculosis |
title_full |
Fluconazole as a therapeutic alternative in infections associated with Mycobacterium tuberculosis |
title_fullStr |
Fluconazole as a therapeutic alternative in infections associated with Mycobacterium tuberculosis |
title_full_unstemmed |
Fluconazole as a therapeutic alternative in infections associated with Mycobacterium tuberculosis |
title_sort |
fluconazole as a therapeutic alternative in infections associated with mycobacterium tuberculosis |
publisher |
Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales |
publishDate |
2018 |
url |
https://doaj.org/article/c6c0467688024fc39698d54eef416aec |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Kasmera, Vol 46, Iss 1, Pp 61-69 (2018) |
op_relation |
https://produccioncientificaluz.org/index.php/kasmera/article/view/24657 https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/c6c0467688024fc39698d54eef416aec |
_version_ |
1779312158160453632 |