Tetanus– a case report highlighting the challenges in diagnosis and treatment

• Published in: Tropical Diseases, Travel Medicine and Vaccines
• Main Authors: Menno Boer, Martijn de Voogd, Nicolasine Diana Niemeijer, Lonneke van Hoeven
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2024
• Subjects: Tetanus; clostridium tetani; Vaccination; Treatment; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1186/s40794-024-00220-5; https://doaj.org/article/c6b434a86c504faf8fae6073bf8129af

Abstract Tetanus has become an increasingly rare infectious disease due to the development of successful vaccination programs in the mid-20th century. In resource-rich countries, mainly unvaccinated or partly vaccinated risk groups are affected, whereas tetanus still remains prevalent in resource-limited countries. The decreasing incidence in developed countries has hindered clinical trials evaluating the best treatment modalities for tetanus infections. Current guidelines are based on a small number of studies and case reports. So far, these studies have shown potential benefits of treating tetanus infections with benzodiazepines, magnesium sulfate and baclofen. Additionally, several treatments have been shown to be useful in stabilizing and supporting patients with tetanus. However, each treatment modality has limitations, from negative side effects to logistical challenges, especially in developing countries. Therefore, further knowledge is required to evaluate the best use of each treatment and to further optimize patient care. This knowledge can contribute to the reduction of the burden of disease in countries where tetanus remains prevalent and where resources are limited, though vaccination is the most effective method to achieve this. This case report describes the treatment of a Dutch patient with tetanus infection and illustrates the role of benzodiazepines as well as other key aspects of treating patients with tetanus.