Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika.
Once Aedes aegypti and Aedes albopictus mosquitoes that spread Chikungunya virus, dengue virus, and Zika virus are infected with Wolbachia, they have reduced egg laying rates, reduced transmission abilities, and shorter lifespans. Since most infected mosquitoes are only infectious in the last few da...
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ftdoajarticles:oai:doaj.org/article:c5f4037fa8794b949cc47b45f8c8539c 2023-05-15T15:07:36+02:00 Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika. Ling Xue Xin Fang James M Hyman 2018-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006666 https://doaj.org/article/c5f4037fa8794b949cc47b45f8c8539c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6085076?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006666 https://doaj.org/article/c5f4037fa8794b949cc47b45f8c8539c PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006666 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006666 2022-12-31T12:35:59Z Once Aedes aegypti and Aedes albopictus mosquitoes that spread Chikungunya virus, dengue virus, and Zika virus are infected with Wolbachia, they have reduced egg laying rates, reduced transmission abilities, and shorter lifespans. Since most infected mosquitoes are only infectious in the last few days of their lives, shortening a mosquito's lifespan by a day or two can greatly reduce their abilities to spread mosquito-borne viral diseases, such as Chikungunya, dengue fever, and Zika. We developed a mathematical model to compare the effectiveness of the wMel and wAlbB strains of Wolbachia for controlling the spread of these viruses. The differences among the diseases, mosquitoes, and Wolbachia strains are captured by the model parameters for the mosquito-human transmission cycle. Moreover, the model accounts for the behavior changes of infectious population created by differences in the malaise caused by these viruses. We derived the effective and basic reproduction numbers for the model that are used to estimate the number of secondary infections from the infectious populations. In the same density of Wolbachia-free Aedes aegypti or Aedes albopictus mosquitoes, we observed that wMel and wAlbB strains of Wolbachia can reduce the transmission rates of these diseases effectively. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 7 e0006666 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ling Xue Xin Fang James M Hyman Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Once Aedes aegypti and Aedes albopictus mosquitoes that spread Chikungunya virus, dengue virus, and Zika virus are infected with Wolbachia, they have reduced egg laying rates, reduced transmission abilities, and shorter lifespans. Since most infected mosquitoes are only infectious in the last few days of their lives, shortening a mosquito's lifespan by a day or two can greatly reduce their abilities to spread mosquito-borne viral diseases, such as Chikungunya, dengue fever, and Zika. We developed a mathematical model to compare the effectiveness of the wMel and wAlbB strains of Wolbachia for controlling the spread of these viruses. The differences among the diseases, mosquitoes, and Wolbachia strains are captured by the model parameters for the mosquito-human transmission cycle. Moreover, the model accounts for the behavior changes of infectious population created by differences in the malaise caused by these viruses. We derived the effective and basic reproduction numbers for the model that are used to estimate the number of secondary infections from the infectious populations. In the same density of Wolbachia-free Aedes aegypti or Aedes albopictus mosquitoes, we observed that wMel and wAlbB strains of Wolbachia can reduce the transmission rates of these diseases effectively. |
format |
Article in Journal/Newspaper |
author |
Ling Xue Xin Fang James M Hyman |
author_facet |
Ling Xue Xin Fang James M Hyman |
author_sort |
Ling Xue |
title |
Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika. |
title_short |
Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika. |
title_full |
Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika. |
title_fullStr |
Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika. |
title_full_unstemmed |
Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika. |
title_sort |
comparing the effectiveness of different strains of wolbachia for controlling chikungunya, dengue fever, and zika. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006666 https://doaj.org/article/c5f4037fa8794b949cc47b45f8c8539c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006666 (2018) |
op_relation |
http://europepmc.org/articles/PMC6085076?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006666 https://doaj.org/article/c5f4037fa8794b949cc47b45f8c8539c |
op_doi |
https://doi.org/10.1371/journal.pntd.0006666 |
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PLOS Neglected Tropical Diseases |
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12 |
container_issue |
7 |
container_start_page |
e0006666 |
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