M2 Polarization of Monocytes-Macrophages Is a Hallmark of Indian Post Kala-Azar Dermal Leishmaniasis.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Debanjan Mukhopadhyay, Shibabrata Mukherjee, Susmita Roy, Jane E Dalton, Sunanda Kundu, Avijit Sarkar, Nilay K Das, Paul M Kaye, Mitali Chatterjee
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2015
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Azar; Indian
• Online Access: https://doi.org/10.1371/journal.pntd.0004145; https://doaj.org/article/c57816c5be604ba38ae38c6aff84bb4b

The high level of functional diversity and plasticity in monocytes/macrophages has been defined within in vitro systems as M1 (classically activated), M2 (alternatively activated) and deactivated macrophages, of which the latter two subtypes are associated with suppression of cell mediated immunity,...