Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Zeng Mei Chun, Jia Qing Jun
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2021
• Subjects: M. tuberculosis; Drug resistance; Gene mutations; Gene sequencing; Arctic medicine. Tropical medicine; RC955-962; Arctic; Rif
• Online Access: https://doi.org/10.1590/0037-8682-0728-2020; https://doaj.org/article/c55004fb46d540939238274d94af3088

Abstract INTRODUCTION: Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide. METHODS: MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced. RESULTS: Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V). CONCLUSIONS: The proportion of mono-SM-resistant TB among new patients was higher.