Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi.
Background Infantile beriberi is a potentially lethal manifestation of thiamin deficiency, associated with traditional post-partum maternal food avoidance, which persists in the Lao PDR (Laos). There are few data on biochemical markers of infantile thiamin deficiency or indices of cardiac dysfunctio...
Published in: | PLoS Neglected Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:c4e825f9e5c842ca8490e4e6247b960d 2023-05-15T15:15:41+02:00 Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi. Douangdao Soukaloun Sue J Lee Karen Chamberlain Ann M Taylor Mayfong Mayxay Kongkham Sisouk Bandit Soumphonphakdy Khaysy Latsavong Kongsin Akkhavong Douangkham Phommachanh Vanmaly Sengmeuang Khonsavanh Luangxay Theresa McDonagh Nicholas J White Paul N Newton 2011-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000971 https://doaj.org/article/c4e825f9e5c842ca8490e4e6247b960d EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21364976/pdf/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000971 https://doaj.org/article/c4e825f9e5c842ca8490e4e6247b960d PLoS Neglected Tropical Diseases, Vol 5, Iss 2, p e971 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000971 2022-12-31T14:37:24Z Background Infantile beriberi is a potentially lethal manifestation of thiamin deficiency, associated with traditional post-partum maternal food avoidance, which persists in the Lao PDR (Laos). There are few data on biochemical markers of infantile thiamin deficiency or indices of cardiac dysfunction as potential surrogate markers. Methodology/principal findings A case control study of 47 infants with beriberi and age-matched afebrile and febrile controls was conducted in Vientiane, Laos. Basal and activated erythrocyte transketolase activities (ETK) and activation (α) coefficients were assayed along with plasma brain natriuretic peptide, N-terminal pro-brain natriuretic peptide and troponin T. Basal ETK (and to a lesser extent activated ETK) and plasma troponin T were the only infant biochemical markers that predicted infantile beriberi. A basal ETK ≤ 0.59 micromoles/min/gHb gave a sensitivity (95%CI) of 75.0 (47.6 to 92.7)% and specificity (95%CI) of 85.2 (66.3 to 95.8)% for predicting infantile beriberi (OR (95%CI) 15.9 (2.03-124.2); p = 0.008) (area under ROC curve = 0.80). In contrast, the α coefficient did not discriminate between cases and controls. Maternal basal ETK was linearly correlated with infant basal ETK (Pearson's r = 0.66, p < 0.001). The odds of beriberi in infants with detectable plasma troponin T was 3.4 times higher in comparison to infants without detectable troponin T (OR 3.4, 95%CI 1.22-9.73, p = 0.019). Detectable troponin T had a sensitivity (95%CI) of 78.6 (59.0 to 91.7) % and specificity (95%CI) of 56.1 (39.7 to 71.5) % for predicting infantile beriberi. Conclusions/significance Basal ETK is a more accurate biochemical marker of infantile beriberi than the activation coefficient. Raised plasma troponin T may be a useful indicator of infantile beriberi in infants at risk and in the absence of other evident causes. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 2 e971 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Douangdao Soukaloun Sue J Lee Karen Chamberlain Ann M Taylor Mayfong Mayxay Kongkham Sisouk Bandit Soumphonphakdy Khaysy Latsavong Kongsin Akkhavong Douangkham Phommachanh Vanmaly Sengmeuang Khonsavanh Luangxay Theresa McDonagh Nicholas J White Paul N Newton Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Infantile beriberi is a potentially lethal manifestation of thiamin deficiency, associated with traditional post-partum maternal food avoidance, which persists in the Lao PDR (Laos). There are few data on biochemical markers of infantile thiamin deficiency or indices of cardiac dysfunction as potential surrogate markers. Methodology/principal findings A case control study of 47 infants with beriberi and age-matched afebrile and febrile controls was conducted in Vientiane, Laos. Basal and activated erythrocyte transketolase activities (ETK) and activation (α) coefficients were assayed along with plasma brain natriuretic peptide, N-terminal pro-brain natriuretic peptide and troponin T. Basal ETK (and to a lesser extent activated ETK) and plasma troponin T were the only infant biochemical markers that predicted infantile beriberi. A basal ETK ≤ 0.59 micromoles/min/gHb gave a sensitivity (95%CI) of 75.0 (47.6 to 92.7)% and specificity (95%CI) of 85.2 (66.3 to 95.8)% for predicting infantile beriberi (OR (95%CI) 15.9 (2.03-124.2); p = 0.008) (area under ROC curve = 0.80). In contrast, the α coefficient did not discriminate between cases and controls. Maternal basal ETK was linearly correlated with infant basal ETK (Pearson's r = 0.66, p < 0.001). The odds of beriberi in infants with detectable plasma troponin T was 3.4 times higher in comparison to infants without detectable troponin T (OR 3.4, 95%CI 1.22-9.73, p = 0.019). Detectable troponin T had a sensitivity (95%CI) of 78.6 (59.0 to 91.7) % and specificity (95%CI) of 56.1 (39.7 to 71.5) % for predicting infantile beriberi. Conclusions/significance Basal ETK is a more accurate biochemical marker of infantile beriberi than the activation coefficient. Raised plasma troponin T may be a useful indicator of infantile beriberi in infants at risk and in the absence of other evident causes. |
format |
Article in Journal/Newspaper |
author |
Douangdao Soukaloun Sue J Lee Karen Chamberlain Ann M Taylor Mayfong Mayxay Kongkham Sisouk Bandit Soumphonphakdy Khaysy Latsavong Kongsin Akkhavong Douangkham Phommachanh Vanmaly Sengmeuang Khonsavanh Luangxay Theresa McDonagh Nicholas J White Paul N Newton |
author_facet |
Douangdao Soukaloun Sue J Lee Karen Chamberlain Ann M Taylor Mayfong Mayxay Kongkham Sisouk Bandit Soumphonphakdy Khaysy Latsavong Kongsin Akkhavong Douangkham Phommachanh Vanmaly Sengmeuang Khonsavanh Luangxay Theresa McDonagh Nicholas J White Paul N Newton |
author_sort |
Douangdao Soukaloun |
title |
Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi. |
title_short |
Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi. |
title_full |
Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi. |
title_fullStr |
Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi. |
title_full_unstemmed |
Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi. |
title_sort |
erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0000971 https://doaj.org/article/c4e825f9e5c842ca8490e4e6247b960d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 2, p e971 (2011) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21364976/pdf/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000971 https://doaj.org/article/c4e825f9e5c842ca8490e4e6247b960d |
op_doi |
https://doi.org/10.1371/journal.pntd.0000971 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
5 |
container_issue |
2 |
container_start_page |
e971 |
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1766346034480414720 |